Tilmicosin smell masking preparation and preparing method thereof

A technology for tilmicosin and preparations, applied in the field of tilmicosin taste-masking preparations and preparation thereof, can solve the problems of not finding tilmicosin taste-masking preparations and the like, and achieves good taste-masking effect, advanced technology, and reduced bitterness. hemp effect

Inactive Publication Date: 2015-10-07
GUANGXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no bibliographical report on the preparation of tilmicosin taste-masking preparations using hot-melt extrusion technology in the prior art

Method used

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  • Tilmicosin smell masking preparation and preparing method thereof
  • Tilmicosin smell masking preparation and preparing method thereof
  • Tilmicosin smell masking preparation and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Take the raw materials tilmicosin and Eudragit EPO respectively, pulverize them, pass through a 80-mesh sieve, and mix them evenly in the ratio of 1:4 by equal incremental dilution method to prepare a physical mixture; use a twin-screw extruder with a screw diameter of 11-16mm , set the melt extrusion temperature of the extruder to 140°C, after the temperature rises to the set value, set the screw speed to 100rpm / min, add the physical mixture after the speed stabilizes, and melt, shear, Convey, obtain easily crushable yellow transparent strip extrudate (see appendix figure 1 ); after the extrudate is cooled, it is pulverized, sieved, and the sieve of 35-50 mesh is retained to obtain tilmicosin hot-melt extruded particles.

Embodiment 2

[0031] Take the raw materials tilmicosin and ethyl cellulose respectively, crush them, pass through a 60-mesh sieve, and mix them uniformly in the ratio of 1:6 according to the equal volume incremental dilution method to prepare a physical mixture; choose a twin-screw extruder with a screw diameter of 11-16mm Out of the machine, set the melt extrusion temperature of the extruder to 160°C. After the temperature rises to the set value, set the screw speed to 80rpm / min. After the speed is stable, add the physical mixture, and melt and shear through the extruder Cutting and conveying to obtain easily crushed transparent strip-shaped extrudates; after the extrudates are cooled, crush and sieve, and keep the sieved objects of 40-50 meshes to obtain tilmicosin hot-melt extruded granules.

Embodiment 3

[0033]Take the raw materials tilmicosin and hydroxypropyl methylcellulose, pulverize them, pass through an 80-mesh sieve, and mix them uniformly in a ratio of 1:5 according to the equal-volume incremental dilution method to prepare a physical mixture; choose a screw with a diameter of 11-16mm For a twin-screw extruder, set the melt extrusion temperature of the extruder to 170°C. After the temperature rises to the set value, set the screw speed to 60rpm / min. After the speed is stable, add the physical mixture, and pass through the extruder. Melting, shearing, conveying to obtain easily crushed transparent strip-shaped extrudates; after the extrudates are cooled, crush and sieve, and retain 40-50 mesh sieves to obtain tilmicosin hot-melt extruded granules.

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PUM

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Abstract

The invention discloses a tilmicosin smell masking preparation and a preparing method thereof, and belongs to the field of antibiotic preparations for livestock. According to the smell masking preparation, tilmicosin and gastric solubility high polymer materials serve as raw materials; and the smell masking preparation is prepared through the steps of fusion through an extruding machine, shearing and conveying. Compared with the prior art, digestion of the tilmicosin smell masking preparation in artificial saliva is slow, so that the effect of stopping releasing of the medicine in the oral cavity is achieved; contact between the medicine and the taste bud of the tongue is less, so that the bitter and hemp tastes can be obviously reduced, and the masking effect is achieved; and the medicine is rapidly released in a 0.01 mol / L hydrochloric acid solution (simulated gastric fluid), and the medicine keeps to play the medicine effect. In addition, the tilmicosin smell masking preparation is prepared with the hot melting extrusion technology, the technology is advanced, the process is simple, organic solvents are not used, and therefore the tilmicosin smell masking preparation is safe and free of pollution; mixing is carried out without a dead corner, the dispersion effect is good, and the medicine losses are fewer; and operation of multiple units is integrated together, so that space is saved, the cost is reduced, and the tilmicosin smell masking preparation is suitable for industrial large-scale production.

Description

technical field [0001] The invention belongs to the field of veterinary antibiotic preparations, and in particular relates to a taste-masking preparation of tilmicosin and a preparation method thereof. Background technique [0002] Tilmicosin is a semi-synthetic macrolide animal-specific antibiotic with a broad antibacterial spectrum and strong antibacterial activity, and is effective against Gram-positive bacteria, some Gram-negative bacteria and mycoplasma. Clinically, it is mainly used to prevent and treat infectious diseases caused by sensitive bacteria in cattle, pigs, sheep, chickens and other animals, especially for livestock and poultry bacterial respiratory diseases. [0003] In recent years, the successfully listed tilmicosin preparations include tilmicosin injection, solution, powder and premix. Oral tilmicosin preparations occupy a major market share, but due to the bitter taste of tilmicosin, the palatability of its oral preparations is relatively poor, and its...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/32A61K47/38A61K31/706A61K9/14A61K9/16A61P31/04A61P11/00
Inventor 何家康彭健波聂海英梁正敏徐杨峰
Owner GUANGXI UNIV
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