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Bitter taste masking method for cefuroxime axetil medicine

A technology of cefuroxime axetil and medicine, which is applied in the field of taste masking of cefuroxime axetil, can solve the problem of unsatisfactory taste masking effect of cefuroxime axetil, and achieve the effect of being easy to swallow, smooth and easy to accept

Inactive Publication Date: 2019-03-08
HAINAN MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to solve the problem that the taste-masking effect of cefuroxime axetil bitterness is not ideal, and propose a method for cefuroxime axetil taste-masking: be about to prepare cefuroxime axetil into taste-masking micro ball

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Heat 3 parts of glyceryl monostearate to 100°C to melt, then add 1 part of cefuroxime axetil powder to mix, under the protection of nitrogen, keep the temperature at 90~100°C, stir well, make cefuroxime axetil in monostearate The acid glyceride is uniformly dispersed; the melt of the above drug and auxiliary materials is frozen and sprayed under heat preservation, the temperature of the spray air inlet is 20°C, and the air temperature of the air outlet is about 30-36°C, and the microspheres are collected. The microspheres were sieved with a 40-mesh sieve to debond large pieces to obtain powdery taste-masking microspheres.

Embodiment 2

[0022] Heat 2 parts of carnauba wax at 90°C to melt, then mix 1 part of cefuroxime axetil powder, under nitrogen protection, keep the temperature at 85-95°C, stir well, so that cefuroxime axetil is uniformly dispersed in carnauba wax; The melt of the above-mentioned drugs and excipients is frozen and sprayed under heat preservation, the temperature of the spray air inlet is 25°C, and the air temperature of the air outlet is about 32-40°C, and the microspheres are collected. The microspheres were sieved with a 60-mesh sieve to debond large pieces to obtain powdery taste-masking microspheres.

Embodiment 3

[0024] Heat 10 parts of stearyl alcohol to 70°C to melt, then mix 1 part of cefuroxime axetil powder, under the protection of nitrogen, keep the temperature at 70-80°C, stir well, so that cefuroxime axetil is uniformly dispersed in stearyl alcohol; The melt of the above-mentioned drugs and excipients was frozen and sprayed under heat preservation. The temperature of the spray air inlet was 15°C, and the air temperature at the outlet was about 22-28°C, and the microspheres were collected. The microspheres were sieved with an 80-mesh sieve to debond large pieces to obtain powdery taste-masking microspheres.

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PUM

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Abstract

The invention relates to a bitter taste masking method for a cefuroxime axetil medicine. The bitter taste masking method comprises the following steps: preparing bitter taste masking microspheres fromcefuroxime axetil, heating and melting the cefuroxime axetil with auxiliary materials, and carrying out freeze spraying. Compared with granules made through common wet-method pelletizing or hot-melting extrusion pelletizing, the obtained microspheres are smaller in particle size. Because of the small particle size, the obtained microspheres are small in dissolution amount in water within a shorttime, good in bitter taste masking effect, small in particle size, smooth in particle, free of gravel feeling when being orally taken, convenient to swallow and easily acceptable by patients. The production process is also relatively simple and convenient to produce.

Description

【Technical field】 [0001] The invention relates to a method for masking the taste of cefuroxime axetil, belonging to the field of pharmacy. 【Background technique】 [0002] As we all know, many medicines have certain peculiar smell, such as bitter taste, special smell, numb taste and so on. These medicines with unacceptable taste are usually made into solid preparations swallowed as a whole, such as coated tablets, capsules and the like. However, formulations swallowed whole are also unsuitable for children or patients who have difficulty swallowing, and suspensions that can be dissolved in water or dispersed into fine particles must be used, such as soluble tablets, granules, solutions or suspensions. But because the medicine in this dosage form is exposed to the outside, it will inevitably directly contact with the taste buds on the oral cavity when taking it, so the bad smell or taste of the medicine can often be felt when taking it. [0003] In the methods of the prior a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/546A61K47/38A61K47/10A61K47/44A61K47/14A61P31/04
Inventor 苏文琴张鹏威
Owner HAINAN MEDICAL COLLEGE
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