Bitter taste masking method for cefuroxime axetil medicine

Abstract

The invention relates to a bitter taste masking method for a cefuroxime axetil medicine. The bitter taste masking method comprises the following steps: preparing bitter taste masking microspheres fromcefuroxime axetil, heating and melting the cefuroxime axetil with auxiliary materials, and carrying out freeze spraying. Compared with granules made through common wet-method pelletizing or hot-melting extrusion pelletizing, the obtained microspheres are smaller in particle size. Because of the small particle size, the obtained microspheres are small in dissolution amount in water within a shorttime, good in bitter taste masking effect, small in particle size, smooth in particle, free of gravel feeling when being orally taken, convenient to swallow and easily acceptable by patients. The production process is also relatively simple and convenient to produce.

Description

【Technical field】

[0001] The invention relates to a method for masking the taste of cefuroxime axetil, belonging to the field of pharmacy. 【Background technique】

[0002] As we all know, many medicines have certain peculiar smell, such as bitter taste, special smell, numb taste and so on. These medicines with unacceptable taste are usually made into solid preparations swallowed as a whole, such as coated tablets, capsules and the like. However, formulations swallowed whole are also unsuitable for children or patients who have difficulty swallowing, and suspensions that can be dissolved in water or dispersed into fine particles must be used, such as soluble tablets, granules, solutions or suspensions. But because the medicine in this dosage form is exposed to the outside, it will inevitably directly contact with the taste buds on the oral cavity when taking it, so the bad smell or taste of the medicine can often be felt when taking it.

[0003] In the methods of the prior a...