Azithromycin taste masking pellet preparation and preparation method thereof

A technology of azithromycin and taste-masked pellets, applied in microcapsules, pharmaceutical formulations, medical preparations with inactive ingredients, etc., can solve the problems of low dissolution rate, low effective bioavailability, large sub-packaging amount, etc. Simple, improved bioavailability and stability, small aliquots

Inactive Publication Date: 2018-03-13
武汉九州钰民医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, in view of the fact that the prior art azithromycin medicine is filled with too much and the dissolution rate is low resulting in low effective bioavailability, the present invention provides a taste-masked pellet preparation of azithromycin and a preparation method thereof, which are suitable for large-scale industrial production

Method used

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  • Azithromycin taste masking pellet preparation and preparation method thereof
  • Azithromycin taste masking pellet preparation and preparation method thereof
  • Azithromycin taste masking pellet preparation and preparation method thereof

Examples

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Embodiment 1

[0045]

Embodiment 2

[0047]

[0048]

Embodiment 3

[0050]

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Abstract

The invention relates to an azithromycin taste masking pellet preparation. The azithromycin taste masking pellet preparation comprises an azithromycin taste masking pellet and a coating layer, whereinthe average particle size of the azithromycin pellets is 160 mu m-200 mu m, the azithromycin pellet contains micro-powder azithromycin, and the average thickness of coating layers is 15 mu m-120 mu m. Compared with common pellets, the azithromycin taste masking pellet well masks the bitter and foreign taste of the medicine, uses no corrigent, reduces packaging quantity of the medicine, improves compliance of children and old patients, is easy to take, and improves bioavailability. Further, the preparation method is advanced, improves product stability and quality, and is suitable for industrial mass production.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular, the invention relates to a taste-masking pellet preparation of azithromycin and a preparation method thereof. Background technique [0002] Azithromycin is a semi-synthetic fifteen-membered ring azalide antibiotic that interferes with bacterial protein synthesis by binding to the subunit of the bacterial 50s ribosome. Clinically, it is mainly used for the treatment of acute pharyngitis, sinusitis, otitis media, pneumonia caused by Haemophilus influenzae and Mycoplasma pneumoniae, urethritis, cervicitis and skin and soft tissue infections caused by sensitive bacteria. Because it has the advantages of good curative effect and low toxic and side effects, it has been widely used clinically and the dosage is increasing day by day. But its taste is extremely bitter, and it is very difficult to cover up, and it is difficult to dissolve in water, so that patients, especially the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K47/32A61K31/7052A61P31/04
Inventor 许勇范昭泽于静胡仁军王浩
Owner 武汉九州钰民医药科技有限公司
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