Preparation method of slow-release tilmicosin microcapsule powder

A technology of tilmicosin and microcapsule powder, which is applied in the field of preparation of sustained-release tilmicosin microcapsule powder, can solve problems affecting palatability, animal stimulation, and affecting the popularization and application of tilmicosin, and achieves improved palatability Sex, smooth release process, good taste-masking effect

Active Publication Date: 2018-10-16
JIANGSU NANNONG GAOKE ANIMAL PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because tilmicosin is very bitter and has an odor, feeding with the mixture will affect palatability on the one hand, and stimulate the stomach of animals on the other hand, causing vomiting in severe cases, and even some animals smell tilmicosin The taste of tilmicosin will not be eaten, which seriously affects the promotion and application of tilmicosin

Method used

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  • Preparation method of slow-release tilmicosin microcapsule powder

Examples

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Effect test

Embodiment 1

[0025] A preparation method for sustained-release tilmicosin microcapsule powder, comprising the following steps:

[0026] Step 1, dissolve 200g of acrylic acid in 1700g of water, adjust the pH of the solution to neutral, then add 400g of starch and 60g of hypromellose, heat up to 50°C, stir to dissolve, then add 400g of tilmicosin raw materials and 20g of chlorinated Calcium, stirring and mixing to obtain mixed solution 1;

[0027] Step 2, add 10.9g of polyethylene glycol 400 and 109g of sodium polyacrylate to the mixed solution 1, stir and dissolve, and then carry out high-pressure homogenization by a homogenizer with a homogenization pressure of 30MPa to obtain a homogeneous solution;

[0028] Step 3, drop 1450 g of sodium alginate aqueous solution with a mass percentage concentration of 10% into the homogeneous liquid under the stirring condition of a stirring speed of 200 rpm, and continue stirring for 40 minutes to obtain a mixed liquid;

[0029] In step 4, the mixed so...

Embodiment 2

[0031] A preparation method for sustained-release tilmicosin microcapsule powder, comprising the following steps:

[0032] Step 1, dissolve 250g of acrylic acid in 2522g of water, adjust the pH of the solution to neutral, then add 500g of starch and 80g of hypromellose, heat up to 53°C, stir to dissolve, then add 500g of tilmicosin raw materials and 28g of chlorinated Calcium, stirring and mixing to obtain mixed solution 1;

[0033] Step 2, add 31g of polyethylene glycol 400 and 232.8g of sodium polyacrylate into the mixed solution 1, stir and dissolve, and then carry out high-pressure homogenization through a homogenizer, with a homogenization pressure of 35MPa, to obtain a homogeneous solution;

[0034] Step 3: Drop 2072 g of a sodium alginate aqueous solution with a concentration of 12% by mass into the homogeneous liquid under the stirring condition of a stirring speed of 230 rpm, and continue stirring for 45 minutes to obtain a mixed liquid;

[0035] In step 4, the mixed...

Embodiment 3

[0037] A preparation method for sustained-release tilmicosin microcapsule powder, comprising the following steps:

[0038] Step 1, dissolve 280g of acrylic acid in 2455g of water, adjust the pH of the solution to neutral, then add 550g of starch and 70g of hypromellose, raise the temperature to 57°C, stir to dissolve, then add 570g of tilmicosin raw materials and 35g of chlorinated Calcium, stirring and mixing to obtain mixed solution 1;

[0039] Step 2, add 39.6g of polyethylene glycol 400 and 277g of sodium polyacrylate into the mixed solution 1, stir and dissolve, and then carry out high-pressure homogenization through a homogenizer with a homogenization pressure of 40MPa to obtain a homogeneous solution;

[0040] Step 3: Drop 2138 g of a sodium alginate aqueous solution with a concentration of 13% by mass into the homogeneous liquid under the stirring condition of a stirring speed of 240 rpm, and continue stirring for 48 minutes to obtain a mixed liquid;

[0041] In step ...

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Abstract

The invention discloses a preparation method of slow-release tilmicosin microcapsule powder. The preparation method comprises the following steps that firstly, acrylic acid is dissolved in water, thepH value of a solution is adjusted to be neutral, then starch and hydroxypropyl methylcellulose are added, heating, stirring and dissolving are carried out, then tilmicosin raw material and calcium chloride are added, and stirring and mixing are carried out to obtain first mixed solution; then polyethylene glycol and sodium polyacrylate are added into the first mixed solution, and after stirring and dissolving, the mixture is homogenized under high pressure by a homogenizer to obtain a homogenized solution; under the condition of stirring, a sodium alginate aqueous solution is dropped into thehomogenized solution and is continuously stirred for 40-50 minutes to obtain a mixed solution; and finally, the mixed solution is dried to obtain the slow-release tilmicosin microcapsule powder. Themicrocapsule powder obtained by the method has good taste masking effect and long-term slow-release effect, can maintain high blood drug concentration in stomach and intestine environment for a long time, and improves curative effect.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a preparation method of sustained-release tilmicosin microcapsule powder. Background technique [0002] Tilmicosin (Tilmicosin) is a relatively new semi-synthesized macrolide antibiotic for livestock and poultry from tylosin, which was successfully developed by the British Elanco animal health products company in the 1980s. Due to its special antibacterial activity and pharmacokinetic characteristics, the drug has been approved for clinical use in the prevention and treatment of infectious diseases in cattle, goats, sheep, dairy cows, pigs, chickens, etc., especially respiratory diseases of livestock and poultry, such as livestock ray Treatment of bacillary pleuropneumonia, pasteurellosis and chicken mycoplasma and lactating animal mastitis. [0003] Tilmicosin has broad-spectrum antibacterial activity similar to tylosin, and has inhibitory effects on Gram-positive bacteria a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K47/10A61K47/32A61K47/36A61K47/38A61K47/02A61K31/706A61P31/04
CPCA61K9/501A61K9/5026A61K9/5036A61K9/5047A61K31/706A61P31/04
Inventor 张笑意朱崇淼韩斌吴肖
Owner JIANGSU NANNONG GAOKE ANIMAL PHARMA CO LTD
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