Taste-masking coating preparation and preparation method thereof

Abstract

The present invention belongs to the field of oral solid preparations, and particularly relates to a taste-masking coating preparation and a preparation method thereof, wherein the taste-masking coating preparation is suitable for patients suffering from dysphagia, and does not have bitter taste. According to the present invention, the drug core is directly subjected to taste masking through a coating technology; the drug active component of the preparation is coated with at least three layers of coats, wherein the three layers of the coats respectively are an acid protection layer, a separation layer and a taste masking layer, such that the drug can be rapidly released while the good taste is provided, the taste masking effect is good, and the taste cannot be released into the oral cavityduring the taking so as not to produce bitterness and other bad tastes; after the preparation enters the stomach environment, the coat membrane is rapidly dissolved, such that the drug is released into the stomach acid environment so as to be absorbed by the body and provide the treatment effect.

Description

technical field [0001] The invention belongs to the field of oral solid preparations, in particular to a taste-masking coating preparation suitable for patients with dysphagia and without bitter taste and a preparation method thereof. Background technique [0002] Oral administration is the most commonly used method of administration. Its advantages lie in its safety and convenience, and it is easy to be accepted and adopted by patients. However, the disadvantage is that it absorbs slowly, and it usually takes half an hour to take effect after oral administration, and it is easily destroyed by the gastrointestinal tract. Drugs that strongly irritate the intestinal tract, or have bad odor, or are poorly absorbed in the gastrointestinal tract and cannot reach the required therapeutic concentration are not suitable for oral preparations. Among them, oral preparations include tablets, capsules, granules, oral liquids and other dosage forms. For children, the elderly and other pa...

AI Technical Summary

Problems solved by technology

However, with the use of water-insoluble ethylcellulose, the release is still affected

[0009] Eudragit dissolves in acid and swells in water and neutral and alkaline environments. Although it overcomes the shortcomings of ethyl cellulose to a certain extent, it is too much affected by the internal environment and relies too much on the gastric acid environment.

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