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Medicine formula for eliminating in-vivo enolotoxin

A bacterial endotoxin and drug technology, applied in antibacterial drugs, drug combinations, pharmaceutical formulations, etc., can solve problems such as endotoxin, poisoning death, fever, etc., to overcome drug resistance, high cure rate, and curative effect. significant effect

Active Publication Date: 2015-07-29
SICHUAN CHENGKANG ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can control the disease in the early stage of animal disease, but it cannot solve the pathogenic endotoxin released after the dead body of the bacteria disintegrates. The endotoxin in the body exceeds the animal's tolerance, causing the animal to generate heat and eventually lead to poisoning die

Method used

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  • Medicine formula for eliminating in-vivo enolotoxin
  • Medicine formula for eliminating in-vivo enolotoxin
  • Medicine formula for eliminating in-vivo enolotoxin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Formula A: flunixin meglumine 1mg / kg body weight, vitamin C 1mg / kg body weight;

[0033] Formula B: ceftiofur sodium 2mg / kg body weight, enrofloxacin 1.5mg / kg body weight;

[0034] Described flunixin meglumine is the injection of 0.05g / ml, and described vitamin C is the injection of 0.1g / ml, and described enrofloxacin is the injection of 0.05g / ml, and described ceftiofur sodium is frozen Dry powder injection.

[0035] Formulas A and B were prepared respectively according to the above doses, and the formulas A and B were intramuscularly injected on both sides of the pig body respectively.

Embodiment 2

[0037] Formula A: flunixin meglumine 1.5mg / kg body weight, vitamin C 2mg / kg body weight;

[0038] Formula B: ceftiofur sodium 3mg / kg body weight, enrofloxacin 2mg / kg body weight;

[0039] Described flunixin meglumine is the injection of 0.05g / ml, and described vitamin C is the injection of 0.1g / ml, and described enrofloxacin is the injection of 0.05g / ml, and described ceftiofur sodium is frozen Dry powder injection.

[0040] Formulas A and B were prepared respectively according to the above doses, and the formulas A and B were intramuscularly injected on both sides of the pig body respectively.

Embodiment 3

[0042] Formula A: flunixin meglumine 2.5mg / kg body weight, vitamin C 3mg / kg body weight;

[0043] Formula B: ceftiofur sodium 5mg / kg body weight, enrofloxacin 2.5mg / kg body weight;

[0044] Described flunixin meglumine is the injection of 0.05g / ml, and described vitamin C is the injection of 0.1g / ml, and described enrofloxacin is the injection of 0.05g / ml, and described ceftiofur sodium is frozen Dry powder injection.

[0045] Formulas A and B were prepared respectively according to the above doses, and the formulas A and B were intramuscularly injected on both sides of the pig body respectively.

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Abstract

The invention relates to a medicine formula for eliminating in-vivo enolotoxin. The medicine formula comprises a formula A and a formula B, wherein the formula A comprises raw materials in parts by weight as follows: 1-4 parts of flunixin meglumine and 1-6 parts of vitamin C; the formula B comprises raw materials in parts by weight as follows: 2-8 parts of ceftiofur sodium and 1.5-5 parts of enrofloxacin, wherein flunixin meglumine is an injection with a specification of 0.05g / ml, the vitamin C is an injection with a specification of 0.1g / ml, enrofloxacin is an injection with a specification of 0.05g / ml, and ceftiofur sodium is a freeze-dried powder injection. The medicine formula can effectively eliminate enolotoxin causing diseases to animals, has high sensitivity to pathogenic bacteria such as escherichia coli, infectious actinobacillus pleuropneumoniae, haemophilus parasuis and the like, can be used for effectively treating diseases such as hydropsy, infectious pleuropneumonia, fevering, loss of appetite and the like caused by the pathogenic bacteria and has remarkable curative effects.

Description

technical field [0001] The invention relates to the preparation technology of veterinary medicine, in particular to a medicine prescription for removing bacterial endotoxin in the body. Background technique [0002] Bacterial endotoxin, called Enolotoxin in English, is a unique structure on the cell wall of G-bacteria. Endotoxin is an exogenous pyrogen, which can activate neutrophils, etc., to release an endogenous heat The original substance acts on the thermoregulatory center to cause fever. Medicine has proved that endotoxin has the following biological activities: 1. Pyrogenicity; 2. Fatal toxicity; 3. Leukopenia; 4. Shwartzman reaction; 8. Stimulate mitosis of lymphocytes; 9. Induce specific resistance against infection; 10. Necrosis of tumor cells. In the field of veterinary medicine, pathogenic bacteria such as Actinobacillus pleuropneumoniae, Haemophilus parasuis, Salmonella typhi, Mycobacterium tuberculosis, Shigella, Escherichia coli and other pathogenic bacteria...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/546A61P31/04A61P7/10A61P11/00A61P29/00A61P1/14A61K31/44A61K31/375A61K31/496
CPCY02A50/30
Inventor 杨军胡进成王芝丽
Owner SICHUAN CHENGKANG ANIMAL PHARMA
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