Long-acting compound florfenicol injection and preparation method thereof

A technology of compound florfenicol and florfenicol, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, which can solve problems such as large animal stress and achieve drug effect time Lengthening, reducing adverse reactions and safety accidents, reducing pain and irritation

Active Publication Date: 2018-10-09
SHANDONG LUKANG SHELILE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above three applications for patents did not solve the problem of frequent drug use, which caused great stress in animals

Method used

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  • Long-acting compound florfenicol injection and preparation method thereof
  • Long-acting compound florfenicol injection and preparation method thereof

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Experimental program
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Effect test

preparation example Construction

[0034] The invention provides a preparation method of the long-acting compound florfenicol injection described in the above scheme, comprising the following steps:

[0035] 1) Mix polyvinylpyrrolidone K30, poloxamer 407, and 75% to 85% of the prescription amount of solvent until dissolved, then add florfenicol and stir to obtain solution A;

[0036] 2) Mix 8% to 12% of the prescription amount of solvent and flunixin meglumine to obtain solution B;

[0037] 3) after mixing the solution A of the step 1) and the solution B of the step 2), then mixing with the remaining amount of solvent to obtain a long-acting compound florfenicol injection;

[0038] The steps 1) and 2) are not limited in time sequence.

[0039] In the present invention, polyvinylpyrrolidone K30, poloxamer 407 and 75%-85% of the prescription amount of solvent are mixed until dissolved, then florfenicol is added and stirred to obtain solution A. In the present invention, it is preferable to mix polyvinylpyrrolidon...

Embodiment 1

[0046] Weigh 10 g of florfenicol, 6.4 g of flunixin meglumine (4 g of flunixin in flunixin meglumine), 301 g of polyvinylpyrrolidone K, and 40720 g of poloxamer. Mix polyvinylpyrrolidone K30, poloxamer 407, and 50 mL of N-methylpyrrolidone until dissolved, then add florfenicol and stir at a speed of 70 r / min for 15 min to obtain solution A. Mix 10 mL of N-methylpyrrolidone, 10 mL of glycerol formal, and flunixin meglumine and stir at a speed of 50 r / min for 25 min to obtain solution B. After mixing solution A and solution B, the volume was adjusted to 100 mL with N-methylpyrrolidone to obtain long-acting compound florfenicol injection.

Embodiment 2

[0048] Weigh 40 g of florfenicol, 1.6 g of flunixin meglumine (1 g of flunixin in flunixin meglumine), 10 g of polyvinylpyrrolidone K30, and 4071 g of poloxamer. Mix polyvinylpyrrolidone K30, poloxamer 407, and 60mL N-methylpyrrolidone until dissolved, then add florfenicol and stir at a speed of 50r / min for 25min to obtain solution A. Mix 5 mL of N-methylpyrrolidone, 5 mL of propylene glycol, and flunixin meglumine and stir at a speed of 70 r / min for 15 min to obtain solution B. After mixing solution A and solution B, the volume was adjusted to 100 mL with N-methylpyrrolidone to obtain long-acting compound florfenicol injection.

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Abstract

The invention provides a long-acting compound florfenicol injection and a preparation method thereof, and belongs to the technical field of medicine preparation. Every 100mL of the injection comprises10-40g of florfenicol, 1-7g of flunixin meglumine, 1-10g of polyvinylpyrrolidone K30, 1-20g of poloxamer 407 and 60-85mL of solvents. The long-acting compound florfenicol injection has long-lasting drug effect which can last more than 40 hours or above, and the number of times for drug administration can be reduced effectively.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, in particular to a long-acting compound florfenicol injection and a preparation method thereof. Background technique [0002] With the high intensification of the breeding industry, the occurrence and prevalence of pig and cattle respiratory diseases have become increasingly serious in recent years, not only causing major economic losses, but also affecting human diet health. When pigs are infected with respiratory diseases caused by Haemophilus parasuis, Pasteurella, Actinobacillus pleuropneumoniae and mycoplasma, they are also accompanied by clinical symptoms such as fever and pain. The compound preparation for treating and alleviating animal stress can meet the current veterinary clinical needs for intensive farming. [0003] Florfenicol, as an animal-specific antibiotic of amide alcohols, is the drug of choice for the prevention and treatment of bacterial respiratory diseases in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/44A61K9/08A61K47/26A61K47/32A61P29/00A61K31/165
Inventor 吉利伟郭强董玲玲彭欣曹海峰韩强赵春蕊
Owner SHANDONG LUKANG SHELILE PHARMA
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