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Preparation method of liposome and product prepared by preparation method of liposome

The invention relates to a preparation method of a liposome and the liposome prepared by the preparation method. The preparation method of the liposome comprises the following steps: (1) respectively preparing a lipoid molecule solution and a guest molecule solution; and (2) mixing the mixed lipoid molecule solution prepared in step (1) with a host molecule solution, so as to obtain the liposome. The liposome obtained by the preparation method is a single-compartment liposome of which the particle size is distributed in the range of 15-100nm, especially, in the range of 20-80nm. The invention also provides a preparation method of a drug-carrying liposome as well as the drug-carrying liposome obtained by the preparation method. The liposome or the drug-carrying liposome prepared by the preparation method is small in particle size and narrow in distribution, so that the liposome drug can be more rapidly administered to the lesion to improve curative effect; moreover, the micro-particle-size liposome prepared by the preparation method is capable of reaching the inside of the tumor tissue where the regular liposome cannot reach. Furthermore, the in-vivo transport time of the liposome drug is shortened by the rapid administration of the liposome drug, so that the degradation loss of the liposome drug by the organism enzyme system and the immune system is further reduced so as to reduce the toxic and side effects.
Owner:王海龙
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