Compound doxycycline hydrochloride injection for animals, and its preparation method

A technology of doxycycline hydrochloride and doxycycline, which is applied in the directions of active ingredients of tetracycline, medical preparations of non-active ingredients, pharmaceutical formulas, etc., can solve problems such as unreported compound preparations, and achieve the alleviation of acute infectivity of animals. Symptoms, rational formulation, effects of broad chemical compatibility

Inactive Publication Date: 2014-05-28
CHINA INST OF VETERINARY DRUG CONTROL
View PDF2 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The compound preparation composed of doxycycline h

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compound doxycycline hydrochloride injection for animals, and its preparation method
  • Compound doxycycline hydrochloride injection for animals, and its preparation method
  • Compound doxycycline hydrochloride injection for animals, and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] Embodiment 1: Preparation of veterinary compound doxycycline hydrochloride injection

[0081] The implementation steps of this embodiment are as follows:

[0082] A, 0.15 gram formaldehyde sulfoxylate sodium antioxidant is dissolved in water for injection, obtains an aqueous solution, then adds described aqueous solution in 45 gram α-pyrrolidone organic solvents, mixes and obtains a kind of mixed solution;

[0083] B. At a temperature of 50°C, add MgCl to the mixed solution obtained in step A in sequence 2 ·6H 2 O complexing agent and 2.5 grams of doxycycline hydrochloride in terms of doxycycline, the mol ratio of the complexing agent and doxycycline is 1.3: 1; stir; then use hydrochloric acid and ethanolamine pH regulator to Its pH was adjusted to 3.0 until a yellow transparent liquid was obtained;

[0084]C, dissolve 0.1 gram formaldehyde sodium sulfoxylate antioxidant and 0.01 gram EDTA-2Na metal ion chelating agent in water for injection, add the solution obtaine...

Embodiment 2

[0085] Example 2: Preparation of Compound Doxycycline Hydrochloride Injection for Veterinary Use

[0086] The implementation steps of this embodiment are as follows:

[0087] A Dissolve 0.2 g of sodium formaldehyde sulfoxylate and sodium metabisulfite (weight ratio 1:1) antioxidant in water for injection to obtain an aqueous solution, and then add the aqueous solution to 50 g of α-pyrrolidone and polyethylene glycol alcohol 400 (volume ratio 7:3) mixed with organic solvents, and mixed evenly to obtain a mixed solution;

[0088] B. Add MgCL successively to the mixed solution obtained in step A at a temperature of 55°C 2 ·6H 2 O complexing agent and 2.5 grams of doxycycline hydrochloride in terms of doxycycline, the molar ratio of the complexing agent and doxycycline is 1.3:1; stir well; then use hydrochloric acid and ethanolamine pH adjuster to Its pH was adjusted to 3.5 until a yellow transparent liquid was obtained;

[0089] C, dissolve 0.1 gram formaldehyde sodium sulfo...

Embodiment 3

[0090] Example 3: Preparation of Compound Doxycycline Hydrochloride Injection for Veterinary Use

[0091] The implementation steps of this embodiment are as follows:

[0092] A. Dissolve 0.3 g of sodium formaldehyde sulfoxylate and sodium bisulfite (weight ratio 1:1) antioxidant in water for injection to obtain an aqueous solution, then add the aqueous solution to 55 g of α-pyrrolidone and Dimethylacetamide (volume ratio 7:5) is mixed with organic solvent, and mixed evenly to obtain a mixed solution;

[0093] B, under temperature 50 ℃, in the mixed solution that step A obtains, add MgO complexing agent and 5 grams of doxycycline hydrochloride in doxycycline successively, the mole of described complexing agent and doxycycline The ratio is 1.5:1; stir evenly; then use hydrochloric acid and ethanolamine pH adjuster to adjust its pH to 4.2, until a yellow transparent liquid is obtained;

[0094] C, dissolve 0.3 gram formaldehyde sodium sulfoxylate antioxidant and 0.02 gram EDTA-...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a compound doxycycline hydrochloride injection for animals, and its preparation method. The above compound preparation is composed of doxycycline hydrochloride and fluoronicotinic acid. The method comprises the following steps: dissolving an antioxidant in injection water, adding the above obtained aqueous solution into an organic solvent, adding doxycycline hydrochloride and a complexing agent, adjusting the pH value, adding a metal ion chelating agent and parts of the antioxidant, adding flunixin dissolved in a proper amount of the organic solvent, uniformly mixing, filtering, filling nitrogen, and disinfecting to obtain the compound doxycycline hydrochloride injection for animals. The compound doxycycline hydrochloride injection prepared in the invention has the advantages of good stability, controllable quality, better treatment effect than single doxycycline hydrochloride injection and flunixin meglumine injection, reduction of the administration frequency, reduction of the labor intensity and the animal stress response, improvement of the treatment effect and efficiency, and wide application prospect in the veterinary clinical medicine.

Description

【Technical field】 [0001] The invention belongs to the technical field of veterinary medicine. More specifically, the present invention relates to a compound doxycycline hydrochloride injection for veterinary use, and also relates to a preparation method of the injection. 【Background technique】 [0002] Compound Doxycycline Hydrochloride Injection is a compound preparation composed of broad-spectrum antibiotic doxycycline and antipyretic and analgesic flunixin. [0003] Doxycycline hydrochloride (DoxycyclineHydrochloride) is a tetracycline antibiotic, alias deoxyoxytetracycline hydrochloride, doxycycline hydrochloride, its antibacterial activity in vitro and in vivo is stronger than similar drugs oxytetracycline and tetracycline. The drug is not only effective against most gram-positive and negative bacteria, but also against spirochetes, actinomycetes, mycoplasma, chlamydia, rickettsia and some protozoa (such as amoeba, coccidia, etc.) It has inhibitory effect and is also ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/65A61K9/08A61K47/18A61K47/04A61K47/08A61P29/00A61P31/00A61K31/44
Inventor 胡海燕徐士新王亦琳朱明文黄耀凌张纯萍宋立徐倩田振祥朱馨乐王鹤佳
Owner CHINA INST OF VETERINARY DRUG CONTROL
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap