Compound ceftiofur sodium freeze-dried power injection used for injection

A technology of ceftiofur sodium and freeze-dried powder injection, which is applied in the field of compound ceftiofur sodium freeze-dried preparations for injection, can solve the problems of bacterial drug resistance and high cost, and achieve the purpose of inhibiting the rise of body temperature and PGF-A concentration , reduce drug resistance, high stability effect

Active Publication Date: 2011-06-29
QILU ANIMAL HEALTH PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to overcome the problems of bacterial drug resistance and high cost of the existing animal-specific cephalosporin antibiotic ceftiofur sodium, the inventor provides a compound ceftiofur sodium freeze-dried powder injection for inject

Method used

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  • Compound ceftiofur sodium freeze-dried power injection used for injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Control the temperature at 10±5°C, add 1 part by weight of sulbactam sodium and 1 part by weight of flunixin meglumine into a sterile container, add water for injection to 85% of the total amount, and turn on the vacuum (to make the system slightly negative). pressure), stir to dissolve, then add 2 parts by weight of ceftiofur sodium to the above solution, turn on the vacuum, stir to dissolve, adjust the pH value to 4.5-6.5, add water for injection to the full amount, and stir evenly.

[0019] Sampling was taken to determine the pH value and the content of ceftiofur sodium, sulbactam sodium, and flunixin meglumine. After the test indicators were qualified, it was first filtered with a 0.45 μm cellulose filter, and then filtered with a 0.22 μm cellulose filter. Remove impurities.

[0020] The filtered filtrate is divided into control glass bottles, half-stopped, and vacuum freeze-dried to obtain the compound ceftiofur sodium freeze-dried powder injection of the present i...

Embodiment 2

[0022] Control the temperature at 10±5°C, add 4 parts by weight of ceftiofur sodium into a sterile container, add water for injection to 85% of the total amount, turn on the vacuum, stir to dissolve, and then add 1 part by weight of sulbactam sodium and 1 Add the flunixin meglumine in parts by weight to the above solution, turn on the vacuum, stir to dissolve, adjust the pH value to 4.5-6.5, add water for injection to the full amount, and stir evenly.

[0023] Sampling was taken to determine the pH value and the content of ceftiofur sodium, sulbactam sodium, and flunixin meglumine. After the test indicators were qualified, it was first filtered with a 0.45 μm cellulose filter, and then filtered with a 0.22 μm cellulose filter. Remove impurities.

[0024] The filtered filtrate was divided into control glass bottles, half-stopped, and vacuum freeze-dried to obtain the compound ceftiofur sodium / sulbactam sodium freeze-dried powder of the present invention.

[0025] For the above...

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Abstract

The invention is a compound ceftiofur sodium freeze-dried power injection used for injection, and the compound ceftiofur sodium freeze-dried power injection provided by the invention is mainly composed of the following effective components in parts by weight: 2-4 parts of ceftiofur sodium, 1 parts of sulbactam sodium and 1 parts of flunixin meglumine; a vacuum freeze drying method is adopted to prepare the effective components into the compound ceftiofur sodium freeze-dried power injection used for injection. The compound ceftiofur sodium freeze-dried power injection has the advantages that the preparation cost can be lowered, and the drug resistance of bacteria on the ceftiofur sodium is relieved; and the broad antimicrobial spectrum is wide, the activity is strong, the drug administration times is less, and low stress and slight side effect are endured; and the negative effect of endotoxin can be effectively blocked.

Description

Technical field: [0001] The invention belongs to the field of animal medicines, in particular to a freeze-dried preparation of compound ceftiofur sodium for injection. Background technique: [0002] Ceftiofur Sodium (Ceftiofur Sodium) is the first third-generation cephalosporin antibiotic for livestock and poultry created by Pharmacia & Upjohn in the United States. The drug acts on transpeptidase to block the synthesis of bacterial cell walls and presents a bactericidal effect. It has strong antibacterial activity against Gram-positive bacteria, Gram-negative bacteria and some anaerobic bacteria. It has clinical antibacterial effect on common livestock and poultry pathogens such as Actinobacillus pleuropneumonia and Pasteurella multocida pneumonia. better. Since it was approved by the FDA in 1988 for the treatment of respiratory infections in cattle, due to its excellent antibacterial activity and dynamic process in vivo, it is now widely used in veterinary clinical treatm...

Claims

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Application Information

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IPC IPC(8): A61K31/546A61K31/43A61K31/44A61K9/19A61P31/04
Inventor 李成应王海挺董丽黄娟吴连勇田玉柱
Owner QILU ANIMAL HEALTH PROD
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