High-concentration compound florfenicol injection, and preparation method and application thereof

A technology of compound florfenil and florfenicol, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, and respiratory system diseases, can solve the problems of large injection volume and inconvenient use, and achieves small injection volume, Easy to use, effective and effective

Inactive Publication Date: 2014-12-17
LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In view of the above, the purpose of the present invention is to provide a solution for the existing unilateral florfenicol injection and flunixin meglumine injection, which have too large injection volume a

Method used

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  • High-concentration compound florfenicol injection, and preparation method and application thereof
  • High-concentration compound florfenicol injection, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Weigh 300 g injection-grade florfenicol raw material and 27.4 g flunixin meglumine raw material, add 200 ml pharmaceutical grade glycerin formal, 200 ml pharmaceutical grade glycerol acetate, 100 ml pharmaceutical grade polyethylene glycol 400, stir Completely infiltrate the raw material drug, then add 250 ml of pharmaceutical grade 1-methyl-2-pyrrolidone, heat to 50 °C, stir well to dissolve, let cool to room temperature, add pharmaceutical grade propylene glycol to 1000 ml, mix well, add Pharmaceutical injection grade activated carbon 4 g, mix well, absorb, filter, subpackage, sterilize, ready to use.

Embodiment 2

[0027] Weigh 400 g of injection-grade florfenicol raw materials and 36.5 g of flunixin meglumine raw materials, add 100 ml of pharmaceutical grade propylene glycol, 100 ml of pharmaceutical grade glycerol acetate, stir to completely infiltrate the raw materials, and then add pharmaceutical grade 1- Add 300 ml of methyl-2-pyrrolidone, add 250 ml of pharmaceutical grade glycerin formal, heat to 50 ℃, stir well to dissolve, let cool to room temperature, add pharmaceutical grade glycerin formal to make up to 1000 ml, mix well, add medicine Injection-grade activated carbon 4g, mix well, absorb, filter, subpackage, sterilize, and you get it.

Embodiment 3

[0029] Take 450 g of injection-grade florfenicol raw materials and 41.1 g of flunixin meglumine raw materials, add 50 ml of pharmaceutical grade propylene glycol, 100 ml of pharmaceutical grade glycerol acetate, and then add 350 ml of pharmaceutical grade 1-methyl-2-pyrrolidone , add 250 ml of pharmaceutical grade glycerin formal, heat to 50 ℃, stir well to dissolve, let cool to room temperature, add pharmaceutical grade glycerin formal to 1000 ml, mix well, add pharmaceutical injection grade activated carbon 4 g, mix well , adsorption, filtration, packaging, sterilization, that is.

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Abstract

The invention discloses a high-concentration compound florfenicol injection, and a preparation method and an application thereof. The method comprises the following steps: dissolving prescription doses of florfenicol and flunixin meglumine in a 75% single solvent, and carrying out heating stirring for dissolving; adding the solvent to a full capacity; adding 0.4% activated carbon, and adsorbing for 30min; and filtering, encapsulating, and carrying out 100DEG C flowing steam sterilization for 30minin order to obtain the high-concentration compound florfenicol injection. The compound florfenicol injection prepared through the preparation method has the advantages of safety, convenience, controllable quality, stable preparation process, suitableness for industrial production, and low cost; and the injection enhances the prevention effect on porcine and bovine infectious diseases caused by pathogenic microorganisms sensitive to florfenicol, improves the survival rate of pigs or cattle, and is suitable for popularization and application.

Description

[0001] technical field [0002] The invention relates to the field of medicine preparation, in particular to a high-concentration compound florfenicol injection and its preparation method and application. Background technique [0003] With the improvement of the intensive degree of livestock and poultry breeding industry and the gradual increase of breeding density, respiratory infectious diseases caused by pathogenic microorganisms have become an important class of diseases that affect the healthy development of pig and cattle breeding. Pasteurella multocida, Pasteurella hemolyticus, Actinobacillus pleuropneumoniae, Streptococcus pneumoniae, Bordetella bronchiseptica, Haemophilus parasuis and mycoplasma, etc.; with respiratory syndrome as the main symptom, the sick animals are depressed, loss of appetite, fever, dyspnea, panting, coughing, sneezing, mucus or purulent secretions in the nostrils, caused by The direct and indirect economic losses are huge. The principle of...

Claims

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Application Information

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IPC IPC(8): A61P29/00A61K31/44A61K9/08A61K31/165A61P11/00A61P31/04
Inventor 杨亚军刘自逵李剑勇刘希望张继瑜
Owner LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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