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Compound sulphamethoxazole injection and preparation method thereof

A technology of sulfamethoxazole and compound sulfonamide, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, respiratory diseases, etc., can solve the problems of mixed infection or secondary infection, poor treatment effect, etc., and achieve continuous drug effect The effect of long time, less frequency of medication, and enhanced efficacy

Active Publication Date: 2013-07-31
河南智盛优品生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These drugs have a certain effect on the control of pathogenic microorganisms. However, at present, due to the mixed infection or secondary infection of pathogenic microorganisms, the therapeutic effect of using them alone is poor.

Method used

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  • Compound sulphamethoxazole injection and preparation method thereof
  • Compound sulphamethoxazole injection and preparation method thereof
  • Compound sulphamethoxazole injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0130] Compound sulfamethoxazole injection of the present invention is characterized in that it is prepared from following raw materials:

[0131] Sulfamethoxazole 5g, trimethoprim 1g, flunixin meglumine 2g, sodium thiosulfate 0.2g, α-pyrrolidone 5ml, benzyl alcohol 2ml, propylene glycol 30ml, ethanolamine 0.5g, water for injection to 100ml;

[0132] Compound sulfamethoxazole injection of the present invention is characterized in that the preparation method comprises:

[0133] In the first step, take water for injection and heat it to 50-60°C, add sodium thiosulfate, ethanolamine, and flunixin meglumine respectively, stir to dissolve them all, and prepare liquid A for use;

[0134] In the second step, take α-pyrrolidone, propylene glycol, and benzyl alcohol, heat it to 70-90°C, add sulfamethoxazole and trimethoprim respectively, stir to dissolve them all, and prepare liquid B;

[0135] In the third step, add liquid A into liquid B and stir evenly, continue to stir for 30 minu...

Embodiment 2

[0138] Compound sulfamethoxazole injection of the present invention is characterized in that it is prepared from following raw materials:

[0139] Sulfamethoxazole 10g, trimethoprim 2g, flunixin meglumine 5g, sodium thiosulfate 0.2g, α-pyrrolidone 10ml, benzyl alcohol 3.5ml, propylene glycol 40ml, ethanolamine 1g, add water for injection to 100ml;

[0140] Compound sulfamethoxazole injection of the present invention is characterized in that the preparation method comprises:

[0141] In the first step, take water for injection and heat it to 50-60°C, add sodium thiosulfate, ethanolamine, and flunixin meglumine respectively, stir to dissolve them all, and prepare liquid A for use;

[0142] In the second step, take α-pyrrolidone, propylene glycol, and benzyl alcohol, heat them to 70-90°C, add sulfamethoxazole and trimethoprim respectively, stir to dissolve them all, and prepare liquid B;

[0143] In the third step, add liquid A into liquid B and stir evenly, continue to stir for...

Embodiment 3

[0146] Compound sulfamethoxazole injection of the present invention is characterized in that it is prepared from following raw materials:

[0147] Sulfamethoxazole 20g, trimethoprim 4g, flunixin meglumine 10g, sodium thiosulfate 0.4g, α-pyrrolidone 10ml, benzyl alcohol 5ml, propylene glycol 45ml, ethanolamine 2g, water for injection to 100ml;

[0148] Compound sulfamethoxazole injection of the present invention is characterized in that the preparation method comprises:

[0149] In the first step, take water for injection and heat it to 50-60°C, add sodium thiosulfate, ethanolamine, and flunixin meglumine respectively, stir to dissolve them all, and prepare liquid A for use;

[0150] In the second step, take α-pyrrolidone, propylene glycol, and benzyl alcohol, heat it to 70-90°C, add sulfamethoxazole and trimethoprim respectively, stir to dissolve them all, and prepare liquid B;

[0151] In the third step, add liquid A into liquid B and stir evenly, continue to stir for 30 min...

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Abstract

The invention discloses a compound sulphamethoxazole injection and a preparation method thereof. The injection is prepared from 5-20 % of the main drug sulphamethoxazole, 2-10 % of flunixin meglumine, 1-4 % of trimethoprim, 0.2-0.4 % of an accessory anti-oxidant, 40-70 % of an organic solvent, 0.5-2 % of an adjusting reagent and the balance being water for injection. The injection prepared by the invention can provide effective treatment for secondary infections and mixed infections of streptococcus diseases, toxoplasmosis, eperythrozoonosis, E. coli diseases, asthma and other diseases, is obvious in long-term effects, with a drug effect being enhanced by several times to dozens of times, small in application amount, few in drug using times, little in irritation and fast in performance of drug effects, saves production cost, increases added value of products, and reduces toxic and side effects due to drug mismatch during treatment.

Description

technical field [0001] The invention relates to the field of veterinary drug preparations, in particular to a compound methoxazole injection and a preparation method thereof. Background technique [0002] In recent years, due to the complexity and diversification of the epidemic, there are more and more cases of mixed infection or secondary infection, such as mixed infection or secondary infection of Escherichia coli and salmonella, staphylococcus and coccidia, streptococcus and swine edema Infection, clinically usually manifests as systemic inflammatory infection and elevated body temperature, etc., which makes the control of the disease more and more difficult. The use of a single drug can no longer achieve a good therapeutic effect, and the dosage is large and the number of medications is many. [0003] Sulfamethoxazole (SMZ for short), also known as 4-amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide, sulfamethoxazole, sulfamethoxazole, sulfamethoxazole , is a more comm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/635A61K9/08A61P31/04A61P29/00A61P11/06A61P33/02A61K31/44A61K31/505
CPCY02A50/30
Inventor 杨灵杰侯中领彭斌
Owner 河南智盛优品生物科技有限公司
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