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Tablet containing flunixin meglumine and preparation method

A technology of flunixin meglumine and tablet, which is applied in the field of sustained-release tablets containing flunixin meglumine and its preparation, can solve the problem of rapid excretion, large irritation of pet gastrointestinal tract, and easy to cause animal stress. Excitement and other issues

Inactive Publication Date: 2013-07-31
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Flunixin meglumine absorbs quickly, but excretes quickly and has a short half-life, requiring multiple administrations to achieve the desired therapeutic effect. Oral administration is highly irritating to the gastrointestinal tract and easily causes animal stress
In the prior art, only flunixin meglumine granules are used in pet clinics, which have the disadvantages of rapid absorption, fast excretion, short half-life, multiple administrations are required to achieve the desired therapeutic effect, and great irritation to the gastrointestinal tract of pets.

Method used

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  • Tablet containing flunixin meglumine and preparation method
  • Tablet containing flunixin meglumine and preparation method
  • Tablet containing flunixin meglumine and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Tablet composition:

[0025]

[0026]

[0027] Preparation Process:

[0028] (1) Hypromellose, lactose, and magnesium stearate are passed through a 80-mesh sieve, and the excipients with larger particle sizes are crushed and sieved for later use; flunixin meglumine is passed through a 100-mesh sieve for later use; starch is made into 5% starch slurry for use;

[0029] (2) Take hypromellose, flunixin meglumine, lactose of recipe quantity, place in granulator, open equipment, make material be in fluidized state, add starch slurry and carry out fluidized granulation;

[0030] (3) dry, 20 mesh sieve granules, add the magnesium stearate of prescription quantity, tabletting, make the tablet that contains 10mg flunixin meglumine.

Embodiment 2

[0032] Tablet composition:

[0033]

[0034] Preparation Process:

[0035] (1) Hypromellose, lactose, and magnesium stearate are passed through a 80-mesh sieve, and the excipients with larger particle sizes are crushed and sieved for later use; flunixin meglumine is passed through a 100-mesh sieve for later use; starch is made into 5% starch slurry for use;

[0036] (2) Take hypromellose, flunixin meglumine, lactose of recipe quantity, place in granulator, open equipment, make material be in fluidized state, add starch slurry and carry out fluidized granulation;

[0037] (3) dry, 20 mesh sieve granules, add the magnesium stearate of prescription quantity, tabletting, make the tablet that contains 10mg flunixin meglumine.

Embodiment 3

[0038] Embodiment 3: same as embodiment 1, the difference is that hydroxypropylmethylcellulose is replaced by carboxymethylcellulose.

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PUM

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Abstract

The invention relates to a tablet containing flunixin meglumine and a preparation method, which belongs to the veterinary drug technical field. The tablet can prolong the action time and reduce the stimulation of drug on gastrointestinal tract, and the pesticide effect is obvious.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a slow-release tablet containing flunixin meglumine and a preparation method thereof. Background technique [0002] Flunixin meglumine is one of the few approved veterinary non-steroidal drugs developed by Schering-Plough in the 1990s. Its molecular formula is as follows: [0003] [0004] Flunixin meglumine is an inhibitor of cyclooxygenase. By inhibiting the cyclooxygenase in the arachidonic acid reaction chain, it can reduce the production of prostaglandins and thromboxane and other inflammatory mediators, maintain normal blood pressure, relieve vascular Endothelial cell damage, maintenance of normal blood volume, etc., prevent E. coli endotoxin from increasing bronchial exudate in respiratory diseases, neutrophils, albumin aggregation in exudate, etc., effectively relieve the body Fever, inflammation and pain. This medicine works quickly, usually ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/44A61K47/32A61K47/34A61K47/36A61K47/38A61P29/00A61K47/10
Inventor 王小武王霞魏德宝
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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