Veterinary florfenicol injection, and preparation method and application thereof
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The technology of florfenicol and injection is applied in the field of veterinary drug preparation, which can solve the problems of poor feeding management and influence on the development of aquaculture, and achieve the effects of low cost, improved curative effect and stable preparation process.
Inactive Publication Date: 2014-11-05
PIZHOU ZHENGKANG BIOTECH
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Problems solved by technology
Due to poor environmental control and feeding management, most of the livestock and poultry are in a sub-healthy state, coupled with the mixed infection of various pathogens, which seriously affects the development of my country's breeding industry.
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Embodiment 1
[0025] (1) Take 260g of the full amount of N-methylpyrrolidone, add 210g of the full amount of propylene glycol and 200g of PEG-400, stir evenly, heat to above 80°C, and set aside; (2) Add florfenyl to the standby solution in (1) in sequence 300g of injection-grade raw materials, 180g of azithromycin, 30g of flunixin meglumine, and 0.04g of scopolamine methyl bromide were stirred and dissolved respectively, and 2ml of hydrazine hydrate (80%) was added to stir well, and the volume was adjusted to the full amount with PEG-400; (3) Filter, fill with nitrogen, potting, and sterilize at 100°C for 30 minutes.
Embodiment 2
[0027] (1) Take 260g of the full amount of N-methylpyrrolidone, add 210g of the full amount of glycerin methylal and 200g of PEG-400, stir evenly, heat to above 80°C, and set aside; (2) Add to the reserve solution in (1) in sequence Florfenicol injection-grade raw materials 300g, azithromycin 180g, flunixin meglumine 30g, and scopolamine methylbromide 0.04g were stirred and dissolved respectively, and 2ml of hydrazine hydrate (80%) was added to stir well, and the volume was adjusted to the full amount with PEG-400; (3) Filtrate, fill with nitrogen, potting, and sterilize at 100°C for 30 minutes.
Embodiment 3
[0029] (1) Take 320g of dimethylacetamide, add 150g of full propylene glycol and 60g of glycerol methylal, stir evenly, and set aside; (2) Add 50g of florfenicol injection-grade raw materials to the standby solution in (1) in turn , Azithromycin 180g, flunixin meglumine 5g, scopolamine methyl bromide 0.004g, heat up to 60°C-80°C, stir to dissolve, dilute to full volume with ethanol, stir well; (3) filter, fill with nitrogen, potting , sterilized at 100°C for 30 minutes, ready to use.
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Abstract
The invention discloses a veterinary florfenicol injection, and a preparation method and application thereof. Per 100 mL of the veterinary florfenicol injection comprises the following compositions by weight: 5-30 g of florfenicol, 15-80 g of an injection solvent, 0.5-3.5 g of a local analgesic, 0.1-1.0 g of an anti-oxidant, and 3-10 g of azithromycin. The injection is prepared by taking florfenicol and azithromycin as the main compositions of the antibacterial anti-inflammation medicine, combining flunixin meglumin and methscopolamine bromide, and employing an organic solvent propylene glycol, PEG-400, NMP, an anti-oxidant and the like. The florfenicol injection is safe and convenient to use, controllable in quality, stable in preparation technology, suitable for industrialized production and relatively low in cost. The florfenicol injection is capable of effectively treating and preventing livestock and poultry bacterial diseases, has special effects especially on respiratory system infection and intestinal infection, and is suitable for popularization and application.
Description
technical field [0001] The invention relates to a veterinary florfenicol injection, in particular to a veterinary florfenicol injection and a preparation method and application thereof, belonging to the technical field of veterinary drug preparation. Background technique [0002] The amount of breeding in our country ranks first in the world, and pork and poultry are also the main body of meat consumption in our country. The degree of intensive and large-scale farming is getting higher and higher. On the other hand, farming is becoming more and more difficult, and disease invasion is the most important factor. Due to poor environmental control and feeding management, most of the livestock and poultry are in a sub-healthy state, coupled with the mixed infection of various pathogens, which seriously affects the development of my country's breeding industry. Respiratory diseases and intestinal diseases have become one of the most important diseases affecting the healthy develo...
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Application Information
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