Veterinary compound enrofloxacin injection and preparation method thereof
A technology for enrofloxacin and injection, which is applied in the field of compound enrofloxacin injection for veterinary use, can solve the problems of small application range and poor antibacterial performance, and achieves broadening the antibacterial spectrum, maintaining stability, and accelerating drug absorption. Effect
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Embodiment 1
[0035] A compound enrofloxacin injection for veterinary use contains the following components, all in parts by weight:
[0036]Enrofloxacin 10g, Sulfamethoxazole 10g, Trimethoprim 5g, Flunixin Meglumine 0.5g, Tylosin 10g, Benzyl Alcohol 10g, Ethanol 20g, N, N Dimethylformamide 10g, α-pyrrolidone 20g, water for injection 4.5g;
[0037] The veterinary compound enrofloxacin injection is prepared by the following steps:
[0038] 1) Mix and dissolve 10 g of enrofloxacin with 10 g of benzyl alcohol to obtain 20 g of enrofloxacin solution;
[0039] 2) Mix and dissolve 10 g of sulfamethoxazole, 5 g of trimethoprim, 0.5 g of flunixin meglumine, 10 g of N, N-dimethylformamide, and 20 g of α-pyrrolidone to obtain sulfamethoxazole, methoxy 45.5 g of mixed solution of benzidine and flunixin meglumine;
[0040] 3) Dissolve 10 g of tylosin in 20 g of ethanol to obtain 30 g of tylosin solution;
[0041] 4) 20 g of enrofloxacin solution prepared in step 1) and 45.5 g of the mixed solution ...
Embodiment 2
[0044] A compound enrofloxacin injection for veterinary use contains the following components, all in parts by weight:
[0045] Enrofloxacin 6g, Sulfamethoxazole 12g, Trimethoprim 4g, Flunixin Meglumine 0.3g, Tylosin 8g, Benzyl Alcohol 15g, Ethanol 15g, N, N Dimethylformamide 20g, α-pyrrolidone 15g, water for injection 5g;
[0046] The preparation steps were the same as in Example 1 to obtain compound enrofloxacin injection for veterinary use, with a pH of 9.5.
Embodiment 3
[0048] A compound enrofloxacin injection for veterinary use contains the following components, all in parts by weight:
[0049] Enrofloxacin 13g, Sulfamethoxazole 6g, Trimethoprim 8g, Flunixin Meglumine 0.5g, Tylosin 5g, Benzyl Alcohol 20g, Ethanol 10g, N,N Dimethylformamide 15g, α-pyrrolidone 20g, water for injection 3g;
[0050] The preparation steps were the same as in Example 1 to obtain compound enrofloxacin injection for veterinary use, with a pH of 9.7.
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