Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Veterinary compound enrofloxacin injection and preparation method thereof

A technology for enrofloxacin and injection, which is applied in the field of compound enrofloxacin injection for veterinary use, can solve the problems of small application range and poor antibacterial performance, and achieves broadening the antibacterial spectrum, maintaining stability, and accelerating drug absorption. Effect

Inactive Publication Date: 2010-03-03
陈建波
View PDF1 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no flunixin meglumine is used in the composition, which is mainly suitable for infectious diseases of pigs, and has disadvantages such as small scope of application and poor antibacterial performance

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Veterinary compound enrofloxacin injection and preparation method thereof
  • Veterinary compound enrofloxacin injection and preparation method thereof
  • Veterinary compound enrofloxacin injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A compound enrofloxacin injection for veterinary use contains the following components, all in parts by weight:

[0036]Enrofloxacin 10g, Sulfamethoxazole 10g, Trimethoprim 5g, Flunixin Meglumine 0.5g, Tylosin 10g, Benzyl Alcohol 10g, Ethanol 20g, N, N Dimethylformamide 10g, α-pyrrolidone 20g, water for injection 4.5g;

[0037] The veterinary compound enrofloxacin injection is prepared by the following steps:

[0038] 1) Mix and dissolve 10 g of enrofloxacin with 10 g of benzyl alcohol to obtain 20 g of enrofloxacin solution;

[0039] 2) Mix and dissolve 10 g of sulfamethoxazole, 5 g of trimethoprim, 0.5 g of flunixin meglumine, 10 g of N, N-dimethylformamide, and 20 g of α-pyrrolidone to obtain sulfamethoxazole, methoxy 45.5 g of mixed solution of benzidine and flunixin meglumine;

[0040] 3) Dissolve 10 g of tylosin in 20 g of ethanol to obtain 30 g of tylosin solution;

[0041] 4) 20 g of enrofloxacin solution prepared in step 1) and 45.5 g of the mixed solution ...

Embodiment 2

[0044] A compound enrofloxacin injection for veterinary use contains the following components, all in parts by weight:

[0045] Enrofloxacin 6g, Sulfamethoxazole 12g, Trimethoprim 4g, Flunixin Meglumine 0.3g, Tylosin 8g, Benzyl Alcohol 15g, Ethanol 15g, N, N Dimethylformamide 20g, α-pyrrolidone 15g, water for injection 5g;

[0046] The preparation steps were the same as in Example 1 to obtain compound enrofloxacin injection for veterinary use, with a pH of 9.5.

Embodiment 3

[0048] A compound enrofloxacin injection for veterinary use contains the following components, all in parts by weight:

[0049] Enrofloxacin 13g, Sulfamethoxazole 6g, Trimethoprim 8g, Flunixin Meglumine 0.5g, Tylosin 5g, Benzyl Alcohol 20g, Ethanol 10g, N,N Dimethylformamide 15g, α-pyrrolidone 20g, water for injection 3g;

[0050] The preparation steps were the same as in Example 1 to obtain compound enrofloxacin injection for veterinary use, with a pH of 9.7.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a veterinary compound enrofloxacin injection and a preparation method thereof. The veterinary compound enrofloxacin injection mainly comprises enrofloxacin, sulfamethoxazole,trimethoprim, flunixin meglumine, tylosin, organic solvent and water for injection. The veterinary compound enrofloxacin injection is used as a veterinary special compound preparation, used for treating various infectious diseases of a respiratory system, a digestive system and a skin soft tissue caused by livestock and poultry bacterial and mycoplasma infection, particularly has special effects on secondary hemophilus disease of pigs and poultries caused by hemophilus and has the advantages of convenient use, short course, low drug resistance and the like.

Description

technical field [0001] The invention relates to a veterinary compound enrofloxacin injection, especially a compound made of enrofloxacin, sulfamethoxazole, trimethoprim, fluninew meglumine and tylosin Formulations and methods for their preparation. Background technique [0002] Enrofloxacin, a representative of the new generation of quinolones, is designated as a special drug for animals. It has a significant effect on various infections caused by a variety of bacteria, and its lethality against various mycoplasma is significantly higher than that of Other quinolone drugs and various drugs such as tylosin and tiomycin, which have been used for many years, have broad spectrum, high efficiency, low toxicity, good absorption and convenient administration. The MIC against most strains is lower than 1 μg / ml, and it has obvious post-antibacterial effect (PAE) on sensitive bacteria. It is suitable for various infectious diseases of digestive system, respiratory system, urinary sy...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/635A61K31/505A61K31/496A61K31/44A61K9/08A61P31/04A61P11/00A61P1/00A61P17/00A61P29/00
Inventor 陈建波
Owner 陈建波
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com