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Application of disophenol to preparation of medicines for treating animal eperythrozoonosis

A technology for eperythrozoonosis and sheep eperythrocytes is applied in the application field of iodonitrophenol in the preparation of medicines for treating eperythrozoonosis in animals, and can solve the problems of easy recurrence, short half-life, limited prevention and treatment effect of tetracyclines, etc. Prominent, fast-acting effects

Inactive Publication Date: 2016-02-03
INSPECTION & QUARANTINE TECH CENT OF FUJIAN ENTRY EXIT INSPECTION & QUARANTINE BUREAU
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Domestic reports on animal eperythrozoonosis are quite common. In some local areas, the disease has become an outbreak, which has reduced the production capacity of livestock and the quality of livestock products, and even caused serious death of livestock or wiped out the whole group. There is no vaccine yet. Tetracyclines, Benier, midazolium and other drugs are often used for treatment. The above drugs have certain effects in in vitro tests and clinical treatments (Heilongjiang Animal Husbandry and Veterinary Medicine, 2003 (8): 50). Our large amount of clinical trial data show that Among them, tetracyclines are the first-selected drugs for the treatment of eperythrozoonosis. The main active ingredients of Fuhongjing and Mixian, which are popular in the market, are all tetracyclines. Due to the short half-life of tetracyclines in animals ( 12h~22h), the treatment of Eperythrozoonosis requires repeated administration
When we used tetracyclines to treat Eperythrozoonosis in animals, we found that a small amount of Eperythrozoon could still be detected in the blood of the treated animals after the clinical symptoms disappeared, and it was easy to relapse, especially in severe outbreaks of Eperythrozoonosis Tetracyclines have limited preventive effect during the epidemic

Method used

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  • Application of disophenol to preparation of medicines for treating animal eperythrozoonosis
  • Application of disophenol to preparation of medicines for treating animal eperythrozoonosis

Examples

Experimental program
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Embodiment 1

[0023] In 2001, Eperythrozoonosis broke out in a pig farm in Tongliao City, Inner Mongolia, causing severe death of pigs. Sick pigs show elevated body temperature, listlessness, loss of appetite, often conjunctivitis, yellow stained eyelids or edema. Redness of the skin can be seen in white pigs. When the course of the disease is a little longer, blood spots appear on the skin of the ears, lower limbs, and under the abdomen. Sick pigs often die due to body failure. Piglets, especially newborn piglets, have severe diarrhea, yellow loose stools, and the whole litter dies within 3 to 5 days. Pathological autopsy showed blood stasis and hemorrhage in the lungs of sick pigs, pulmonary interstitial edema, enlarged lymph nodes and spleen to varying degrees, hemorrhagic spots or edema in the coronary fat, soft myocardium, and pale color. Microscopic examination of the blood tablet shows that the red blood cells are thorn-like protrusions, and there are various round or semicircular "...

Embodiment 2

[0028] From 2002 to 2003, pig farms where eperythrozoonosis was prevalent in Zhengzhou, Jiaozuo, Nanyang and other places in Henan Province used iodonitrophenol to prevent and treat porcine eperythrozoonosis, and the cumulative use of 20wt% iodonitrophenol injection reached 12000ml. More than 100,000 big and small pigs were involved. The clinical symptoms of sick pigs all disappeared after 3 to 4 days after treatment. Blood test showed that the shape of red blood cells returned to normal, and eperythrocytic bodies disappeared in the blood after 7 days. Avoid mass death of pigs and recover huge economic losses.

Embodiment 3

[0030] A cattle farmer in Changle City, Fujian Province had 88 fattening cattle in stock. After being infected with Eperythrozoon, self-treatment failed, and 36 cattle died. Application of 20% iodonitrophenol injection, dose of 0.5ml / 10kg per head, one-time subcutaneous injection, the clinical symptoms of sick cattle gradually disappeared after treatment, and cured after 7 days, blood test showed that the shape of red blood cells returned to normal, and the Eperythrozoon in the blood disappeared. After the treatment, 47 cattle of the cattle farmer survived and 5 died of exhaustion.

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Abstract

Disophenol is an anthelmintic veterinary medicine and mainly used for treating trematodiasis and gastrointestinal nematodosis of various animals. A chemical name of the disophenol is 2,6-diiodo-4-nitrophenol, and a molecular formula of the disophenol is C6H3I2NO3. By application of the disophenol to preparation of medicines for treating animal eperythrozoonosis, animal eperythrozoon can be strongly inhibited and killed, and extraordinary effects are achieved.

Description

technical field [0001] The invention belongs to the field of application of iodonol, in particular to the application of iodonol in the preparation of medicaments for treating animal eperythrozoonosis. Background technique [0002] Nitrophenol (Disophenol), alias: diiodonitrophenol or diiodonitrophenol, chemical name is 2,6-diiodo-4-p-nitrophenol (2,6-diiodo-4-nitropheno1), molecular formula: C 6 h 3 I 2 NO 3 . Iodonitrophenol was developed by the American cyanamide company, and was approved for production and application by the U.S. government in 1965. Niiodophenol is used as a veterinary anti-helminth drug, which was developed in my country in 1991 and was approved by the Ministry of Agriculture in 1995 for production by Shenyang Veterinary Medicine Factory (Veterinary Medicine World, 2005 (9): 45). [0003] Niiodophenol is mainly used to treat trematodes and gastrointestinal nematodes in various animals. It has been widely used in animal husbandry and has achieved hu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/06A61P31/04
Inventor 白泉阳傅光华黄瑜王建华
Owner INSPECTION & QUARANTINE TECH CENT OF FUJIAN ENTRY EXIT INSPECTION & QUARANTINE BUREAU
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