Medicinal composition and injection for treating swine eperythrozoonosis, and preparation methods thereof

Abstract

The invention relates to a medicinal composition and an injection for treating swine eperythrozoonosis, and preparation methods thereof. The medicinal composition comprises imidocarb hydrochloride, doxycycline hydrochloride, a non-steroidal anti-inflammatory medicament, and glucocorticoid and salt thereof. The injection consists of the following components in percentage by weight: 5 to 15 percent of imidocarb hydrochloride, 5 to 10 percent of doxycycline hydrochloride, 2 to 20 percent of non-steroidal anti-inflammatory medicament, 0.05 to 0.5 percent of glucocorticoid and salt thereof, 0.5 to 5 percent of magnesium chloride, 0.1 to 0.2 percent of antioxidant, 0.01 to 0.05 percent of metal complexing agent, 5 to 20 percent of propylene glycol, and the balance of water for injection. The medicinal composition and the injection have the characteristics of reasonable prescription formulation, stable medicinal physical and chemical properties, accurate dose, quick response, long medicinal effect maintaining time, high bioavailability, safe use and exact curative effect.

Description

technical field [0001] The invention relates to a veterinary drug, in particular to a pharmaceutical composition, an injection and a preparation method thereof for treating porcine eperythrozoonosis. Background technique [0002] Eperythrozoonosis is a disease characterized by decreased hematocrit, decreased hemoglobin concentration, leukocytosis, anemia, jaundice, and fever, which are parasitic on the surface of red blood cells, plasma, and bone marrow by Eperythrozoons. zoonoses. Eperythrozoon infection in pigs is generally a recessive infection, mostly under the action of stress factors. The clinical symptoms of sick pigs are mainly manifested as lack of energy, anorexia, elevated body temperature, anemia and jaundice. According to reports, the mortality rate of piglets can be as high as 90%. The disease can occur all year round, mainly in warm and humid seasons, and it is mostly of natural origin and has a strong prevalence. It can generally pass through 5 ways: digest...

AI Technical Summary

Problems solved by technology

According to many literature reports, tetracycline, oxytetracycline, doxycycline and arsine preparations have obvious inhibitory effects on it. The main drug for treating porcine Eperythrozoonosis is triazamidine, but the blood concentration of triazamidine is high after administration. The curative effect is better when used in the early stage of pig disease, the duration is short, the preventive effect is poor, and the curative effect on pigs with chronic infection or severe symptoms is not exact, and there is relapse in the cured pigs

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