Medicinal composition and injection for treating swine eperythrozoonosis, and preparation methods thereof

A technology of porcine epierythrocyte and composition, which is applied in the directions of drug combination, extracellular fluid disease, pharmaceutical formula, etc., can solve the problems of short duration, high blood concentration, inaccurate curative effect, etc., and achieve short course of treatment and drug resistance. Low, curative effect

Active Publication Date: 2010-06-16
HENAN HUITONG TIANXIA BIO ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to many literature reports, tetracycline, oxytetracycline, doxycycline and arsine preparations have obvious inhibitory effects on it. The main drug for treating porcine Eperythrozoonosis is triazamidine, but the blood concentration of triazamidine is high aft...

Method used

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  • Medicinal composition and injection for treating swine eperythrozoonosis, and preparation methods thereof
  • Medicinal composition and injection for treating swine eperythrozoonosis, and preparation methods thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] 1. The pharmaceutical composition for the treatment of porcine eperythrozoonosis consists of the following components by weight percentage:

[0041] Midazolium Hydrochloride 17%

[0042] Doxycycline Hydrochloride 17%

[0043] Analgin 65%

[0044] Dexamethasone Sodium Phosphate 1%.

[0045] 2. The injection for the treatment of porcine eperythrozoonosis, the injection consists of the following components by weight percentage:

[0046] Midazolium Hydrochloride 5%

[0047] Doxycycline Hydrochloride 5%

[0048] Analgin 20%

[0049] Dexamethasone Sodium Phosphate 0.3%

[0050] Magnesium Chloride 0.5%

[0051] Sodium bisulfite 0.2%

[0052] Disodium EDTA 0.02%

[0053] Propylene Glycol 5%

[0054] The balance is water for injection.

[0055] 3. The preparation method of the injection for the treatment of porcine eperythrozoonosis is carried out in the following steps:

[0056] (1) Take an appropriate amount of water for injection, dissolve magnesium chloride, add so...

Embodiment 2

[0060] 1. The pharmaceutical composition for the treatment of porcine eperythrozoonosis consists of the following by weight percentage:

[0061] Midazolium Hydrochloride 25%

[0062] Doxycycline Hydrochloride 28%

[0063] Aspirin 45%

[0064] Cortisone 2%.

[0065] 2. The injection for the treatment of porcine eperythrozoonosis, the injection consists of the following components by weight percentage:

[0066] Midazolium Hydrochloride 7%

[0067] Doxycycline Hydrochloride 8%

[0068] Aspirin 13%

[0069] Cortisone 0.5%

[0070] Magnesium Chloride 1%

[0071] Sodium bisulfite 0.12%

[0072] Calcium Disodium EDTA 0.01%

[0073] Propylene Glycol 10%

[0074] The balance is water for injection.

[0075] 3. The preparation method of the injection for the treatment of porcine eperythrozoonosis is carried out in the following steps:

[0076] (1) Take an appropriate amount of water for injection, dissolve magnesium chloride, add sodium bisulfite and disodium edetate to diss...

Embodiment 3

[0080] 1. The pharmaceutical composition for the treatment of porcine eperythrozoonosis consists of the following by weight percentage:

[0081] Midazolium Hydrochloride 35%

[0082] Doxycycline Hydrochloride 35%

[0083] Magnesium Salicylate 29.8%

[0084] Prednisone 0.2%.

[0085] 2. The injection for the treatment of porcine eperythrozoonosis, the injection consists of the following components by weight percentage:

[0086] Midazolium Hydrochloride 10%

[0087] Doxycycline Hydrochloride 10%

[0088] Magnesium Salicylate 8.5%

[0089] Prednisone 0.05%

[0090] Magnesium Chloride 2%

[0091] Sodium metabisulfite 0.15%

[0092] Disodium EDTA 0.03%

[0093] Propylene Glycol 15%

[0094] The balance is water for injection.

[0095] 3. The preparation method of the injection for the treatment of porcine eperythrozoonosis is carried out in the following steps:

[0096] (1) Take an appropriate amount of water for injection, dissolve magnesium chloride, add sodium metabi...

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PUM

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Abstract

The invention relates to a medicinal composition and an injection for treating swine eperythrozoonosis, and preparation methods thereof. The medicinal composition comprises imidocarb hydrochloride, doxycycline hydrochloride, a non-steroidal anti-inflammatory medicament, and glucocorticoid and salt thereof. The injection consists of the following components in percentage by weight: 5 to 15 percent of imidocarb hydrochloride, 5 to 10 percent of doxycycline hydrochloride, 2 to 20 percent of non-steroidal anti-inflammatory medicament, 0.05 to 0.5 percent of glucocorticoid and salt thereof, 0.5 to 5 percent of magnesium chloride, 0.1 to 0.2 percent of antioxidant, 0.01 to 0.05 percent of metal complexing agent, 5 to 20 percent of propylene glycol, and the balance of water for injection. The medicinal composition and the injection have the characteristics of reasonable prescription formulation, stable medicinal physical and chemical properties, accurate dose, quick response, long medicinal effect maintaining time, high bioavailability, safe use and exact curative effect.

Description

technical field [0001] The invention relates to a veterinary drug, in particular to a pharmaceutical composition, an injection and a preparation method thereof for treating porcine eperythrozoonosis. Background technique [0002] Eperythrozoonosis is a disease characterized by decreased hematocrit, decreased hemoglobin concentration, leukocytosis, anemia, jaundice, and fever, which are parasitic on the surface of red blood cells, plasma, and bone marrow by Eperythrozoons. zoonoses. Eperythrozoon infection in pigs is generally a recessive infection, mostly under the action of stress factors. The clinical symptoms of sick pigs are mainly manifested as lack of energy, anorexia, elevated body temperature, anemia and jaundice. According to reports, the mortality rate of piglets can be as high as 90%. The disease can occur all year round, mainly in warm and humid seasons, and it is mostly of natural origin and has a strong prevalence. It can generally pass through 5 ways: digest...

Claims

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Application Information

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IPC IPC(8): A61K31/65A61K31/4178A61K45/06A61P7/00
Inventor 张要齐张新蕾
Owner HENAN HUITONG TIANXIA BIO ENG
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