Compound artemisinin multiphase lipidosome injection as well as preparation method thereof
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A multiphase liposome and compound artemisinin technology, which is applied in liposome delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of high equipment requirements and expensive equipment, and achieve high safety , good stability and high encapsulation efficiency
Active Publication Date: 2014-02-05
四川维尔康动物药业有限公司
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Abstract
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Problems solved by technology
[0006] Reverse-phase evaporation, freeze-drying, etc. require high equipment and expensive equipment
[0007] In short, the above methods are suitable for laboratory preparation, but there are still some difficulties in applying them in large-scale production.
Method used
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Embodiment 1
[0021] The compound artemisinin multiphase liposome injection includes medicinal ingredients and injection auxiliary ingredients, wherein the medicinal ingredients are made of artemisinin and triazamidine, and the injection auxiliary ingredients are lecithin, cholesterol, Tween -80, phosphate buffer and absolute ethanol.
[0022] The components are calculated in parts by weight: 1 part of lecithin, 0.5 parts of cholesterol, 5 parts of Tween-80, 5 parts of artemisinin, 5 parts of triazamidine, 10 parts of absolute ethanol, and 50 parts of phosphate buffer.
Embodiment 2
[0024] The compound artemisinin multiphase liposome injection includes medicinal ingredients and injection auxiliary ingredients, wherein the medicinal ingredients are made of artemisinin and triazamidine, and the injection auxiliary ingredients are lecithin, cholesterol, Tween -80, phosphate buffer and absolute ethanol.
[0025] The components are calculated in parts by weight: 10 parts of lecithin, 5 parts of cholesterol, 3 parts of Tween-803, 5 parts of artemisinin, 4 parts of triazamidine, 8 parts of absolute ethanol, and 45 parts of phosphate buffer.
Embodiment 3
[0027] The compound artemisinin multiphase liposome injection includes medicinal ingredients and injection auxiliary ingredients, wherein the medicinal ingredients are made of artemisinin and triazamidine, and the injection auxiliary ingredients are lecithin, cholesterol, Tween -80, phosphate buffer and absolute ethanol.
[0028] The components are calculated in parts by weight: 30 parts of lecithin, 10 parts of cholesterol, 0.5 parts of Tween-800, 1 part of artemisinin, 3 parts of triazamidine, 7 parts of absolute ethanol, and 55 parts of phosphate buffer.
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Abstract
The invention belongs to the field of veterinary drugs, and specifically relates to a compound artemisinin multiphase lipidosome injection as well as a preparation method thereof. The injection comprises a medicinal component and an auxiliary material of the injection, wherein the medicinal component is prepared from artemisinin and diminazene aceturate, and the auxiliary material of the injection consists of lecithin, cholesterol, tween-80, a phosphate buffer and absolute ethyl alcohol. The injection comprises the following components in parts by weight: 1-30 parts of lecithin, 0.5-10 parts of cholesterol, 0.1-5 parts of tween-80, 0.5-5 parts of artemisinin, 0.5-5 parts of diminazene aceturate, 1-15 parts of absolute ethyl alcohol and 5-90 parts of the phosphate buffer. The compound artemisinin multiphase lipidosome injection prepared by the preparation method disclosed by the invention is remarkable in curative effect in treating eperythrozoonosis of livestock and poultry in clinical treatment of veterinarians, and is high in safety. Several methods are organically combined, i.e., an ethanol injection-ultrasonic treatment-homogenization method is adopted. The compound artemisinin multiphase lipidosome injection prepared by the method is high in encapsulation efficiency, good in stability, strong in operability and applicable to industrialized production on a large scale.
Description
technical field [0001] The invention belongs to the field of veterinary medicine, and specifically relates to a compound artemisinin multiphase liposome injection with high encapsulation rate, good stability, high safety and remarkable curative effect and a preparation method thereof. Background technique [0002] Artemisinin is a compound that was first isolated from Artemisia annua by Chinese scientists in the early 1970s. It is currently recognized as the most effective drug for the treatment of cerebral malaria and chloroquine-resistant falciparum malaria in the world. It has been approved by the World Health Organization (WHO) recommended drug of choice for the treatment of malaria. [0003] Pharmacological studies have confirmed that in addition to antimalarial effects, artemisinin also has anti-pregnancy, anti-fibrosis, anti-schistosome, anti-toxoplasma, anti-arrhythmia and tumor cytotoxic effects. In veterinary clinics, artemisinin has a strong effect on Eperythrozo...
Claims
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Application Information
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