Long-acting oxytetracycline injection and preparation method thereof

Abstract

The invention discloses a long-acting oxytetracycline injection and a preparation method of the long-acting oxytetracycline injection, and belongs to the technical field of veterinary preparations. Every 1000ml of the injection comprises the following components: 100-240 g of oxytetracycline, 120-140 g of sodium formaldehyde sulfoxylate, 300-400 g of propylene glycol, 80-120 g of magnesium chloride, 10-50 ml of ethanol amine, 50-100 g of pullulan-polyglutamic acid cross-linked polymer, 10-20 ml of honeysuckle extracting solution, 10-20 ml of buckwheat tea extracting solution, and the balance of water for injection. The product quality is stable, the long-acting oxytetracycline injection does not change the color and does not precipitate in the guarantee period, the drug effect lasts for 4 days by injecting once, and the long-acting oxytetracycline injection has better treatment effects on treating doldrums and hyperthermia caused by eperythrozoonosis, swine enzootic pneumonia, mycoplasma and rickettsial diseases of pigs, as well as high fever and systemic diseases.

Description

technical field [0001] The invention relates to a long-acting oxytetracycline injection and a preparation method thereof, belonging to the technical field of veterinary medicine. Background technique [0002] Oxytertracycline (OTC) is extracted from the culture solution of Streptococcus in soil. Wide antibacterial range, strong antibacterial effect, good curative effect on infections caused by gram-positive bacteria, gram-negative bacteria, mycoplasma, chlamydia, rickettsia, Eperythrozoon porcine, etc. The role of prevention and treatment of disease. And there are few drug-resistant strains, less toxic and side effects, and lower drug residues. It can also be used as a feed additive to promote the growth of livestock and poultry. Oxytetracycline injection with long-acting effects was developed by Pfizer in the 1980s, and the effect is very good on the market. Although the imported oxytetracycline injection has good quality and long drug effect, the market price is very h...

AI Technical Summary

Problems solved by technology

Although the quality of imported oxytetracycline injection is good and the drug effect is long, the market price is very high, and long-term use has brought huge economic pressure to the majority of farmers and livestock farmers.

At present, there are many long-acting oxytetracycline injections for sale in China, but the products produced by most pharmaceutical companies are extremely unstable, with lower and lower active ingredients, poor efficacy, easy oxidation and blackening, and poor quality controllability

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