Compound sulfamonomethoxine/compound sulfamonomethoxine sodium injection and preparation method

Abstract

The invention discloses a compound sulfamonomethoxine / compound sulfamonomethoxine sodium injection which is prepared from main components and auxilary components, wherein the main components comprise 5-20 parts by weight of sulfamonomethoxine / sulfamonomethoxine sodium, 1-4 parts by weight of diclofenac sodium and 1-4 parts by weight of trimethoprim and the auxilary components comprise 0.2-0.4 part by weight of antioxidant, 40-70 parts by weight of organic solvent, 0.2-1 part by weight of regulating reagent and 10-20 parts by weight of water for injection. The injection prepared by the invention can provide effective treatment on secondary infection and mixed infection of streptococcicosis, toxoplasmosis, eperythrozoonosis, colibacillosis, asthma and other diseases, has obvious effect if applied for a long term, strong effect enhanced by several times or dozens of times, hardly generates drug resistance and has the advantages of less consumption, less application times, little irritation and quick treatment effect, can treat both symptoms and root causes, save production cost, improve product additional value and reduce toxic or side effects caused by mismatching of medicaments during treatment.

Description

technical field The invention relates to the field of veterinary drug preparations, in particular to a compound sulfamethoxine injection, a compound sulfamethoxine sodium injection and a preparation method thereof. Background technique Sulfa drugs are a class of drugs commonly used. Sulfamonomethoxine (SMM) is a new type of sulfa drugs with the strongest antibacterial effect in vivo and in vitro. Its structure is similar to p-aminobenzoic acid (PABA). PABA competitively acts on the dihydrofolate synthase in bacteria, thereby blocking the process of PABA as a raw material for the synthesis of folic acid required by bacteria, reducing the amount of metabolic tetrahydrofolate, which is the synthesis of DNA and thymine by bacteria The essential substance of nucleic acid, so it can inhibit the growth and reproduction of bacteria. It has a strong inhibitory effect on most Gram-positive bacteria and negative bacteria, and bacteria are slow to develop resistance to this drug. SMM ...

AI Technical Summary

Problems solved by technology

These drugs have a certain effect on the control of bacteria and protozoa. However, at present, due to the infection of bacteria and protozoa, there are often mixed infections or secondary infections, such as mixed infections such as streptococcosis, toxoplasmosis, and eperythrozoonosis, Escherichia coli Infection with asthma and asthma, and the infection of these diseases is clinically manifested as strong infectivity, high fever and inflammation. The single treatment effect of sulfamethoxine sodium injection is poor, and it is usually injected twice a day, which is more irritating. Strong, large injection volume

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