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Quke rutin granule agent and its preparation method

A technology of granules and main drug, applied in the field of Troxerutin granules and preparation thereof, can solve the problems of inconvenience of taking high-content Troxerutin tablets, inability to treat venous insufficiency and hemorrhoids, and achieve lasting curative effect The effect of stabilizing, strengthening resistance, and enhancing venous tension

Inactive Publication Date: 2004-12-22
SICHUAN XIELI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to overcome the inconvenience of taking the high-content troxerutin tablet involved in the prior art and the prior art, and can not effectively treat venous insufficiency and hemorrhoids, and provide a kind of drug that can effectively improve microscopic High-content troxerutin granule with better curative effect on venous insufficiency and hemorrhoids based on circulation and blood rheology and preparation method thereof

Method used

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  • Quke rutin granule agent and its preparation method
  • Quke rutin granule agent and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Troxerutin granule, comprising principal agent and auxiliary material, is characterized in that being formulated into the granule that the principal agent content is 500g (in 1000 packs) by following percentage by weight: principal agent 45%, auxiliary material is cyclamate of 1% , 52% mannitol and 2% polyvinylpyrrolidone.

[0030] Troxerutin granule of the present invention is formulated from the raw materials of following weight ratio:

[0031] Troxerutin 500g

[0032] Cyclamate 11g

[0033] Mannitol 578g

[0034] Polyvinylpyrrolidone 22g

[0035] A total of 1000 packs were made

[0036] Wherein, cyclamate is a flavoring agent, mannitol is a filler, and polyvinylpyrrolidone is a binder.

[0037] The preparation method of troxerutin granule of the present invention comprises the steps of drying, pulverizing, sieving, weighing, mixing, granulating, granulating, measuring and subpackaging, and is characterized in that: the specific process steps are as follows:

[...

Embodiment 2

[0046] Troxerutin granules, including main drug and auxiliary materials, are characterized in that the granules whose main drug content is 5000g (in 1000 bags) are formulated according to the following percentage by weight: main drug 55%, and auxiliary materials are 1% cyclamate , 43% mannitol and 1% polyvinylpyrrolidone.

[0047] Troxerutin granule of the present invention is formulated from the raw materials of following weight ratio:

[0048] Troxerutin 5000g

[0049] Cyclamate 91g

[0050] Mannitol 3910g

[0051] Polyvinylpyrrolidone 91g

[0052] A total of 1000 packs were made

[0053] Wherein, cyclamate is a flavoring agent, mannitol is a filler, and polyvinylpyrrolidone is a binder.

[0054] The preparation method of troxerutin granule of the present invention comprises the steps of drying, pulverizing, sieving, weighing, mixing, granulating, granulating, measuring and subpackaging, and is characterized in that: the specific process steps are as follows:

[0055] ...

Embodiment 3

[0063] Troxerutin granules, including main ingredients and auxiliary materials, are characterized in that they are formulated into granules whose main ingredient content is 3500g (in 1000 packs) according to the following weight percentage proportioning: main ingredient 50%, auxiliary ingredients 1% Cyclamate, 48% mannitol and 1% polyvinylpyrrolidone.

[0064] Troxerutin granule of the present invention is formulated from the raw materials of following weight ratio:

[0065] Troxerutin 3500g

[0066] Cyclamate 70g

[0067] Mannitol 3360g

[0068] Polyvinylpyrrolidone 70g

[0069] A total of 1000 packs were made

[0070] Wherein, cyclamate is a flavoring agent, mannitol is a filler, and polyvinylpyrrolidone is a binder.

[0071] The preparation method of troxerutin granule of the present invention comprises the steps of drying, pulverizing, sieving, weighing, mixing, granulating, granulating, measuring and subpackaging, and is characterized in that: the specific process st...

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Abstract

A granular troxerutin for improving microcirculation and treating venous insufficiency and pile is prepared from troxerutin, sweetening agent, mannitol and polyvinyl pyrrolidone through drying, pulverizing, sieving, proportionally mixing, and granulating. Its advantage is high curative effect.

Description

Technical field: [0001] The invention relates to an oral preparation for treating chronic vascular diseases and a preparation method thereof, in particular to a troxerutin granule which can improve microcirculation and blood rheology and have better curative effect on venous insufficiency and hemorrhoids and its preparation method. Background technique: [0002] Rutin is generally classified as vitamins. Some people call it vitamin P. It is often used in combination with vitamin C to enhance the effect of vitamin C. It is often used as an adjuvant treatment for high blood pressure. It is known to prevent erythrocyte aggregation, reduce capillary permeability, and help maintain and restore capillary elasticity. Troxerutin is a semi-synthetic derivative of rutin. It is the extract of Sophora japonica, and the active ingredient is trihydroxyethyl rutin. It has the functions of preventing abnormal increase of vascular permeability and inhibiting the aggregation of red blood cel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/352A61P9/10A61P9/14
Inventor 张光耀
Owner SICHUAN XIELI PHARM CO LTD
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