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Troxerutin brain protein hydrolysate for injection and preparation process thereof

A technology of cerebroprotein hydrolyzate and water for injection, which is applied in the field of compound preparations for the treatment of cerebrovascular and central nervous system diseases, to achieve the effect of repairing intima damage, inhibiting platelet aggregation, and promoting repair and regeneration

Inactive Publication Date: 2006-02-22
李志林
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Using this product alone is not effective for improving the physiological function of brain cells and the protection of cranial nerves

Method used

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  • Troxerutin brain protein hydrolysate for injection and preparation process thereof
  • Troxerutin brain protein hydrolysate for injection and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Example 1 Preparation of Troxerutin Cerebroprotein Hydrolyzate for Injection

[0012] Weigh 80g of troxerutin, 200g of cerebroprotein hydrolyzate stock solution (total nitrogen is calculated at 5.0mg / ml), and 700g of water for injection, mix them, add water for injection to 1000ml, add injection-grade medicinal charcoal according to 0.07% of the liquid volume, and store at room temperature Stir and absorb for 30 minutes, first pass through coarse filtration, after the determination is qualified, pass through a 0.22 μm microporous membrane filter, put it into vials, and put it in a freeze-drying box (pre-frozen to -40°C). Keep warm for 2 hours; turn on the switch of the water trap and the vacuum pump, and gradually increase the temperature by 1°C per hour under 4Pa. When chamber temperature was reached, the vacuum was continued for 3 hours. After the freeze-drying is completed, open the elevator of the freeze-drying machine, fully press the rubber stopper in, then pass ...

Embodiment 2

[0013] Example 2 Preparation of Troxerutin Cerebroprotein Hydrolyzate for Injection

[0014] Take troxerutin 200g, cerebroprotein hydrolyzate stock solution 500g (total nitrogen is calculated at 5.0mg / ml), water for injection 700g, mix, add appropriate amount of water for injection to 2300ml, add injection-grade medicinal charcoal according to 0.07% of the liquid amount, Stir and adsorb at room temperature for 30 minutes, first pass through coarse filtration, and pass through 0.22 μm microporous membrane after the determination is qualified, then pack it separately, put it in a freeze-drying box (pre-frozen to -40°C), and keep it warm at this temperature for 30 minutes. hours; turn on the switch of the water trap and the vacuum pump, and gradually increase the temperature by 1°C per hour under 4Pa. When chamber temperature was reached, the vacuum was continued for 3 hours. After the freeze-drying is completed, open the elevator of the freeze-drying machine, completely press t...

Embodiment 3

[0015] Example 3 Preparation of Troxerutin Cerebroprotein Hydrolyzate for Injection

[0016] Weigh 400g of troxerutin, 1000g of cerebroprotein hydrolyzate stock solution (total nitrogen is calculated at 5.0mg / ml), 700g of water for injection, mix, add water for injection to 5000ml, add injection-grade medicinal charcoal according to 0.07% of the liquid volume, and store at room temperature Stir and absorb for 30 minutes, first pass through coarse filtration, pass through a 0.22μm microporous membrane after the determination is qualified, then pack it separately, put it in a freeze-drying box (pre-frozen to -40°C), and keep it at this temperature for 3 hours ; Turn on the switch of the water catcher and the vacuum pump, and gradually increase the temperature by 1°C per hour under 4Pa. When chamber temperature was reached, the vacuum was continued for 3 hours. After the freeze-drying is completed, open the elevator of the freeze-drying machine, completely press the rubber stopp...

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Abstract

The invention relates to a troxerutin brain protein hydrolysate for injection and preparation process, for treating cerebrovascular diseases and neurous system diseases, which is prepared from Troxerutin and Cerebrolysin by the weight ratio of 50-100 : 1-20, preferably 80:1, the pH of the composition is between 5.5-7.5. Its preparing process is also disclosed in the invention.

Description

technical field [0001] The invention relates to a troxerutin cerebroprotein hydrolyzate for injection, which is a compound preparation for treating cerebrovascular and central nervous system diseases. Background technique [0002] Cerebrovascular diseases mainly include cerebral thrombosis, cerebral embolism, lacunar infarction, cerebral hemorrhage, cerebral arteriosclerosis, etc. The symptoms of these diseases include complete or incomplete aphasia, limb paralysis, pain or thinking disturbance, insomnia, daze , memory loss, tinnitus, brain function decline and other symptoms, these symptoms have brought great misery to the patient, the cure rate of existing treatment medicine is low, can not cure, can only relieve symptoms, curative effect is slow. [0003] The related preparations of troxerutin have been widely used clinically, which can inhibit the aggregation of red blood cells and platelets, prevent thrombus formation, increase blood oxygen saturation, and improve micro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/01A61P7/02A61P9/10A61K31/352
Inventor 李志林黄瑶蔡鹤其
Owner 李志林
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