Combination composition, comprising as active ingredients L-carnitine or propionyl L-carnitine, for the prevention or treatment of chronic venous insufficiency

Abstract

A combination composition comprising as active ingredients L-carnitine or propionyl L-carnitine, troxerutine, diosmine and hesperidine, useful for the prevention and / or treatment of chronic venous diseases.

Description

RELATED APPLICATIONS[0001]This application claims priority to and benefit of U.S. Provisional Application No. 61 / 322,532 filed Apr. 9, 2010, the contents of which are herein incorporated by reference.FIELD OF THE INVENTION[0002]The present invention relates to a combination composition comprising as active ingredients L-carnitine or a derivative thereof, or a salt thereof, troxerutine, diosmine and hesperidine, useful for the prevention and / or treatment of chronic venous insufficiency (CVI).BACKGROUND OF THE INVENTION[0003]In humans, arteries bring oxygen-rich blood from the heart to the rest of the body and veins return oxygen-poor blood back to the heart. When human leg veins cannot pump enough blood back to heart, there is the onset of chronic venous insufficiency (CVI). CVI is also sometimes called chronic venous disease, or CVD.[0004]Humans have three kinds of veins: superficial veins, which lie close to the skin, deep veins, which lie in groups of muscles, and perforating vein...

AI Technical Summary

Benefits of technology

[0055]Their procurement therefore is very easy, inasmuch as these are products which have been on the market now for a long time and are of a grade suitable for human administration.

Problems solved by technology

But when patient sit or stand, especially for a long time, the blood in the leg veins can pool and increase the venous blood pressure.

However, sitting or standing for a long time can stretch vein walls because they are flexible.

Over time, in susceptible individuals, this can weaken the walls of the veins and damage the vein valves, causing CVI.

The legs may also feel heavy, tired, restless, or achy.

Patient may feel pain while walking or shortly after stopping.

Large varicose veins can lead to skin changes like rashes, redness, and sores.

CVI can also cause problems with leg swelling because of the pressure of the blood pooling in the veins.

Human leg tissues may then absorb some of this fluid, which can increase the tendency for the legs to swell.

In severe cases, CVI and the leg swelling can cause ulcers to form on the lower parts of the leg.

The blood trying to pass through the blocked veins can increase the blood pressure in the vein, which, in turn, overloads our valves.

Vein valves that do not work properly are called incompetent because they stretch and no longer work efficiently, and incompetent valves contribute to CVI.

DVT is a potentially serious condition that causes leg swelling and requires immediate medical attention because sometimes the blood clots in the veins can break off and travel to the lungs.

This inflammation causes a blood clot to form, which can also lead to DVT.

Factors that can increase the risk for CVI include a family history of varicose veins, being overweight, being pregnant, not exercising enough, smoking, and standing or sitting for long periods of time.