105 results about "Aortic rings" patented technology

The invention relates to actuators based on electroactive polymeric materials for use in pumping fluids or in other applications where a contractile actuation is required, in particular although not necessarily exclusively for use in vascular pulsation devices such as a variable aortic tension device. Embodiments disclosed include an actuator (10) comprising: an inner tubular structure (15, 12); an outer tubular structure (13, 14) surrounding the inner tubular structure (15, 12) and comprising a plurality of layers of a dielectric elastomeric material (13) and a tubular elastic support structure (14), the elastic support structure (14) configured to maintain a pre-stress in the layers of the dielectric elastomeric material (13), wherein the outer tubular structure (13, 14) is configured to contract in a radial direction around the inner tubular structure (12, 15) upon application of an actuation voltage signal across the dielectric elastomeric material layers (13).

The combination of amlodipine and atorvastatin act to synergistically synthesize NO production. Moreover, the addition of a tertiary compound complements this combination of amlodipine and atorvastatin in NO production.

The present invention comprises poly(vinyl benzoate) nanoparticle suspensions as molecular carriers. These nanoparticles can be formed by nanoprecipitation of poly(vinyl benzoate) in water using Pluronic F68 as surfactant, to create spherical nanostructures measuring about 200-250 nm in diameter which are stable in phosphate buffer and blood serum, and only slowly degrade in the presence of esterases. Kinetics experiments in phosphate buffer indicate that 78% of the coumarin-6 was encapsulated within the polymer matrix of the nanoparticle, and the residual 22% of coumarin-6 was surface-bound and quickly released. The nanoparticles are non-toxic in vitro towards human epithelial cells (IC50>1000 μg / mL) and primary bovine primary aortic endothelial cells (IC50>500 μg / mL), and exert non-observable bactericidal activity against a selection of representative test microbes (MIC >250 μg / mL). Poly(vinyl benzoate) nanoparticles are suitable carriers for molecular delivery of lipophilic small molecules such as drugs pharmaceutical and imaging agents.

The present invention discloses the use of ammidin in preparing medicine for treating cardiac and cerebral vascular diseases. Experiments shows that ammidin has obvious blood vessel relaxing effect, and can relax KCl and ET-1 pre-retracted rat arteria mesenterica and NA and U46619 pre-retracted human caul artery. Ammidin relaxes blood vessel without dependent on endothelial cell. Ammidin relaxes blood vessel mainly by means of inhibiting the outer calcium inflow and the inner calcium release mediated by the voltage depending calcium channel and acceptor calcium channel and slightly depending on KCa channel. Ammidin may be used in preparing medicine for treating cardiac and cerebral vascular diseases.

The invention discloses application of FAM210B in the preparation of diagnostic tools for abdominal aortic aneurysm. Experiments prove that FAM210B has expression differences in normal control tissues and abdominal aortic aneurysm tissues; therefore, it is reckoned that FAM210B is a molecular marker for diagnosing abdominal aortic aneurysm. Experiments via in-vitro cultured cells prove that by accelerating the expression of FAM210B, it is possible to inhibit the apoptosis of human aortic smooth muscle cells; therefore, it is reckoned that FAM210B is a drug target for treating abdominal aortic aneurysm. As a new molecular marker for diagnosing and treating abdominal aortic aneurysm, the molecular marker has a promising clinical application prospect.

The invention provides a method for obtaining an interested aortic pressure curve, and a storage medium. The method comprises the following steps of obtaining aortic pressure Pa data; extracting a stable pressure waveform according to the aortic pressure Pa; generating an aortic pressure waveform image according to the stable pressure waveform; obtaining a moment of interest; and selecting a corresponding aortic pressure curve from the aortic pressure waveform image according to the interested moment. According to the method, the interested aortic pressure curve part can be obtained from the continuous aortic pressure curve, in this way, the influence of the objective environment can be avoided, and meanwhile the defect that clinically analyzing the aortic pressure curve only depends on observation and experience is overcome.

The invention relates to a method for preparing for taspine alkali and the applied in preparing for the drug to treat tumor. The preparing method comprises: preparing for dissolving solution, dissolving the cohosh root base, adsorption stripping, preparing for eluent, cleaning, and concave condensation, recrystallizing and checking. The 222 test result expresses that it has the effect of depressing blood vessel formation.

The present invention is directed to methods and compositions for preventing or reducing atherosclerotic lesions and plaques. Specifically, the instant invention provides methods for using humanin and its analogues to prevent or reduce the formation of atherosclerotic plaques. Also provided are methods of using humanin and its analogues to improve the survival of endothelial cells, particularly aortic endothelial cells.

The present invention generally relates to the field of treatment of fibroproliferative diseases and disorders and cancer. Embodiments of the present invention generally relate to compositions, methods and kits comprising an inhibitor of a portion of the N-terminal pro-fibrotic domain (PFD) of Aortic Carboxypeptidase-Like Protein (ACLP), and in some embodiments, in combination with an inhibitor of the discoidin (DS) domain of ACLP, for use in methods for the treatment of fibroproliferative diseases and cancer, and inhibition of ACLP-mediated activation of a member of the TGFβ receptor superfamily.

The invention discloses an aortic dissection stent containing a chip and a monitoring system of the aortic dissection stent; the aortic dissection stent comprises a stent body, the chip and a covering film; the stent body is composed of a plurality of single stents and a plurality of connection segments; each single stent is of 'star' structure composed of a main segment and four repair segments, and the main segment and the connection segments are connected at 90 degrees; the chip is fixedly mounted at the lower end of the stent body; the covering film covers the stent and the chip and is integrated to the four repair segments. The aortic dissection stent of the invention is a novel medical biomaterial, capable of better improving the repair function of aortic dissection at low recurrence rate, and the dissolved chip in the dissection enables restoration of the aortic dissection to be monitored.

Modulation of neural activity of a subject's aortic depressor nerve (ADN) and / or carotid sinus nerve (CSN) can modulate baroreceptor reflex function, thereby providing ways of treating or preventing disorders associated with malfunction or loss of the baroreceptor reflex.

The invention discloses a furocoumarin compound, and a preparation method and medical application thereof. The furocoumarin compound is a novel compound having vasodilating activity; and the compoundis obtained by structurally modifying and optimizing the natural product xanthotoxin to improve its physical and chemical properties, pharmacological activity and drug-forming properties. The preparation method for the furocoumarin compound provided by the invention has the advantages that raw materials are widely available, reaction conditions are mild, reaction process is simple to operate and reagents used therein are cheap and easily available. The prepared novel furocoumarin compound has effect similar to the effect of xanthotoxin; the study results of isolated vascular ring tension indicate that the relaxation effect of the novel furocoumarin compound on the aortic vessels of rat is stronger than the relaxation effect of xanthotoxin and the positive control drug nifedipine; the cytotoxicity of the novel furocoumarin compound on normal liver cells L02 in vitro is significantly lower than the cytotoxicity of nifedipine; and the results of in-vivo antihypertensive studies show thatthe antihypertensive effect of the novel furocoumarin compound is stronger than the antihypertensive effect of xanthotoxin and nifedipine, so the novel furocoumarin compound can be applied to the preparation of antihypertensive drugs.

A magnetic resonance imaging MRI) apparatus, including a signal transceiver; a controller configured to control the signal transceiver to apply a bipolar gradient magnetic field in an aortic direction, the aortic direction being a direction in which an aorta is disposed within an object; and an image processor configured to receive, from the signal transceiver, phase signal data obtained by applying the bipolar gradient magnetic field to the object, acquire motion data representing a first motion corresponding to a heartbeat of the object and a second motion corresponding to a respiration of the object based on the phase signal data, and acquire MRI data based on the motion data.

The invention relates to a recombinant virus silencing a T1 protein, and a construction method and an application thereof, and belongs to the technical field of biomedicine. Firstly, a shRNA silencingthe T1 protein is designed and synthesized and then is introduced into a viral vector, and then the viral vector is packed to prepare the recombinant virus silencing the T1 protein. The recombinant virus can highly efficiently infect aorta endothelium in mouse bodies, is expressed in aortic endothelial cells for a long time, can protect integrity of endothelial barrier of atherosclerotic model mice, promotes the expression of endothelial cadherin, and significantly inhibits the development of atherosclerosis. The recombinant virus silencing the T1 protein is expected to become a genetic drugfor treatment of atherosclerosis related diseases.

A support layer for a synthetic root comprises at least a first region and a second region. The pattern, material, density and / or tension of the support layer in the first region is different to that in the second region. The support may be formed from a knitted, woven, braided or 3D-printed material. The support layer may be comprised within a synthetic aortic or pulmonary root. In at least one region the synthetic root may have a multi-layered structure with the support layer disposed between an inner and an outer nanofiber layer.

The invention belongs to the technical field of pharmaceutical preparations and nanomedicine, and relates to a bionic nano-drug for preventing and treating aortic dissection, in particular to a mononuclear / macrophage membrane bionic modified multidrug co-loaded anti-inflammatory liposome and a preparation method thereof. The liposome is composed of cationic phospholipid and neutral phospholipid, co-loading of multiple anti-inflammatory drugs can be achieved in the liposome, anti-inflammatory cell-penetrating peptide is covalently modified on the surface of the liposome, and then mononuclear / macrophage membrane protein is used for bionic modification. According to the bionic anti-inflammatory liposome, multiple receptors and adhesion molecular ligands mediated and chemotactic on the surface of a mononuclear / macrophage membrane are utilized to realize a natural targeting effect on an inflammatory site, and non-specific clearance of a reticuloendothelial system (RES) to the liposome is reduced by virtue of modification of leukocyte self-recognition molecules. The bionic anti-inflammatory lipidosome can effectively cross a vascular endothelial barrier, gather and release anti-inflammatory drugs at the early lesion part of the aortic dissection in a targeted manner, play a synergistic anti-inflammatory role, inhibit inflammation-related cells from chemotaxis and infiltration into the lesion part, and further prevent and treat the occurrence and development of the aortic dissection.

The embodiments of the invention provide a type B aortic dissection postoperative risk prediction method and device, and an electronic device, and relates to the technical field of medical images. Thetype B aortic dissection postoperative risk prediction method comprises the steps that firstly, a plurality of cases of preoperative three-dimensional angiography images are obtained, and all cases of the three-dimensional angiography images are pretreated to obtain a to-be-treated data set, wherein the to-be-treated data set comprises blood vessel true lumen information and blood vessel false lumen information; then the blood vessel true lumen information and the blood vessel false lumen information are subjected to vector analysis to obtain various image omics feature information, and the various image omics feature information is subjected to dimensionality reduction treatment and linear fitting to obtain risk factor variables; and finally, a risk predicting model is constructed according to the risk factor variables and a preset clinical lesion type. In this way, the risk probability of postoperative complications can be obtained, and thus patient safety is ensured.

The invention relates to the technical field of aortic dissection animal models and methods for manufacturing the same and provides a Stanford A type aortic dissection animal model and a method for manufacturing the same. Compared with the conventional method for manufacturing a Stanford A type aortic dissection animal model, the method for manufacturing a Stanford A type aortic dissection animal model, which is provided by the invention, has the advantages that the time for manufacturing the ascending aortic dissection is reduced and the success rate of manufacture of the Stanford A type aortic dissection animal model is increased. Meanwhile, the control to the false lumen length of the Stanford A type aortic dissection animal model lays an experiment foundation for the investigation of the Stanford A type aortic dissection pathogenesis and new therapeutic methods.

The embodiment of the invention discloses a 5G-based aortic replacement surgery remote intelligent screening system, and relates to the technical field of data processing. The system comprises an image device used for collecting image data of a target object; a 5G ultrasonic networking system used for transmitting the image data to a remote cloud computing center through a 5G network; an aorticstenosis measurement algorithm module used for acquiring image data acquired by the image equipment from the remote cloud computing center; a case database module used for storing image data of a plurality of target objects; and a cloud computing scheduling system used for carrying out data scheduling on the 5G ultrasonic networking system, the aortic stenosis measurement algorithm module and the case database module. Through the scheme of the embodiment of the invention, the efficiency of the aorta replacement operation can be effectively improved.

The invention provides a preparation method of a single-cell suspension of aortic cells, which comprises the following steps: firstly treating aortic vascular tissues, and then carrying out secondary digestion reaction to obtain the single-cell suspension with high single cell yield, large quantity, high cell activity and strong cell function. The technical problem that a traditional aortic cell single-cell suspension is low in efficiency, and obtained cells are poor in quality is solved.

A pulse wave conduction parameter measurement system and method comprises: acquiring, by one or more processors, first vibration information of a supine subject from a first fiber optic sensor, the first fiber optic sensor being configured to be placed under a back region corresponding to the fourth thoracic vertebral body of the supine subject (step 711); acquiring, by the one or more processors, second vibration information of the supine subject from a second fiber optic sensor, the second fiber optic sensor being configured to be placed under a lumbar region corresponding to the fourth lumbar body of the supine subject (step 713); and generating, by the one or more processors, first hemodynamic related information on the basis of the first vibration information, and generating second hemodynamic related information on the basis of the second vibration information (step 715), thereby determining an aortic Pulse Wave Transit Time of the supine subject (step 719).

The invention discloses a preparation method and application of inonotus obliquus polysaccharide. Through water extraction and alcohol precipitation, repeated freeze thawing, deproteinization, dialysis, freeze drying, affinity chromatography and other methods, a polysaccharide component with antioxidant and anti-aging functions is separated and purified from inonotus obliquus; the inonotus obliquus polysaccharide component has strong antioxidant activity; through pretreatment of the inonotus obliquus polysaccharide, etoposide-induced proliferation inhibition and apoptosis of rat aortic smoothmuscle cells can be inhibited, and etoposide-induced cellular senescence beta-galactosidase activity increase, senescence-related heterochromatin aggregation and mitochondrial membrane potential decline can be inhibited; through pretreatment of the inonotus obliquus polysaccharide, etoposide-induced increase in expression levels of p53, p21 and p16 protein and mRNA can be inhibited. The inonotus obliquus polysaccharide components prepared according to the preparation method provided by the invention has good antioxidant and anti-aging activity and has a broad application prospect as a novel anti-aging protective medicine.

The embodiment of the invention discloses an aortic dissection evaluation method anddevice, equipment and a storage medium. The method comprises acquiring a to-be-processed image and clinical information of a current object, and constructing a geometric model comprising a target segmentation part according to the to-be-processed image; meshing the geometric model, determining an inlet and at leastone outlet of the geometric model, determining boundary conditions of the inlet and at least one outlet of the geometric model according to the to-be-processed image and the clinical information, andperforming hemodynamic simulation based on the boundary conditions; verifying the hemodynamic simulation result according to the clinical information; when the hemodynamic simulation result does notpass the verification, adjusting the boundary conditions of the geometric model, and performing hemodynamic simulation on the geometric model based on the adjusted boundary conditions; and taking theverified hemodynamic simulation result as an evaluation result of the aortic dissection. The aortic dissection is evaluated from the perspective of hemodynamics, and the accuracy of an aortic dissection evaluation result is improved.

The invention requests to protect the application of the asparagine endopeptidase inhibitor RR-11aanalog in preparation of the medicine for treating the aortic dissection, it is found through experiments that asparagine endopeptidase serves as a target spot for occurrence of the aortic dissection, and the RR-11aanalog has the effect of treating the aortic dissection and has great clinical significance in further development of related treatment medicine.

The invention relates to a full-type aortic dissection true and false cavity image segmentation method and system. The method comprises the steps: segmenting a to-be-segmented true and false cavity image through a segmentation network model based on an attention mechanism, mapping an obtained mask image into the to-be-segmented true and false cavity image, and obtaining a segmentation result; in the process of training the segmentation network model, marking an aorta region, a true cavity and a false cavity, extracting aorta dissection spatial correlation of true and false cavity data by using 3D convolution, and performing up-and-down sampling by using a mixed attention module as a basic unit to apply a weight to the true and false cavity data, and completing prediction of each pixel value category is completed through exponential function normalization. The problem of non-full automation in the prior art is solved on the premise that the segmentation precision is ensured, and the aortic dissection true and false cavity segmentation neural network model based on the attention mechanism is put forward, so that the model is more sensitive to the distinguishing of true and false cavities, and the precision of the model is improved.

The invention provides an aortic pressure waveform image generation method and a storage medium. The aortic pressure waveform image generation method comprises the steps of obtaining aortic pressure Pa data; extracting a stable pressure waveform according to the aortic pressure Pa; setting a display interval of the stable pressure waveform; setting a data range of the stable pressure waveform; andgenerating an aortic pressure waveform image according to the display interval, the data range and the stable pressure waveform. According to the method, the aortic pressure waveform image can be rapidly, accurately and automatically generated from the original aortic pressure data by means of the heartbeat cycle and the pressure transmission rate.

The invention provides an instantaneous waveform-free ratio generation method and a device thereof, equipment and a medium, and the method comprises the steps: building the corresponding relation between the pressure waveform features of an aorta and the coordinates of a target point through the self-learning capability of an artificial neural network with a feature enhancement layer; obtaining the current pressure waveform features of the current aorta of the patient; and determining a current target point coordinate corresponding to the current pressure waveform feature through the corresponding relation; specifically, the step of determining the current target point coordinates corresponding to the pressure waveform feature comprises the steps that the target point coordinates corresponding to the pressure waveform feature which is same as the current pressure waveform feature in the corresponding relation are determined as the current target point coordinates; and a current instantaneous waveform-free ratio is generated according to the current target point coordinate. The high-level space information is used for positioning a target point, so that the information expression robustness is higher, the feature enhancement layer is added, and unobvious feature points caused by individual differences can be positioned.

The invention discloses application of millet bran active polyphenol in preparation of a product for preventing and treating atherosclerosis. Experiments prove that the millet bran active polyphenol can significantly inhibit migration ability of human aortic smooth muscle cells, can significantly inhibit lipid phagocytosis ability of the human aortic smooth muscle cells and human mononuclear macrophages, and can inhibit formation of in-vivo atherosclerotic plaques, thereby preventing and treating atherosclerosis. The millet bran active polyphenol is taken as a main component and can be used for preparing functional foods or medicines for preventing and / or treating atherosclerosis.

The invention provides a primary mouse thoracic aortic endothelial cell separation and culture method, which solves the problems of great difficulty in primary VECs (vascular endothelial cell) in-vitro culture, low cell activity and little output in the prior art. The method comprises: (Step 1) a mouse thoracic aortic section is obtained, and after separation and purification, the mouse thoracic aortic section is produced into an aortic ring; (Step 2) a matrigel is used for pretreating the bottom of a culture vessel; (Step 3) the aortic ring is inoculated to the surface of the matrigel, an endothelial cell culture medium which contains an endothelial cell growth-assisting factor and heparin is then added into the culture vessel for culture; (Step 4) after 3 to 7 days of culture, the aortic ring is removed, and culture is continued. The method is easy and convenient to implement, economical and applicable, and has the advantages of decreasing the probability of impurity cell contamination, increasing the survival rate and output of cells, enabling VECs to have high activity and high multiplication rate, etc..

The invention belongs to the technical field of aortic aneurysm auxiliary diagnosis, and particularly relates to a deep learning-based computed tomography aortic aneurysm auxiliary diagnosis method, which comprises the following steps of: 1, data acquisition: firstly, retrospectively collecting a plurality of common CT scans with aorta from a hospital area of a hospital; 2, data processing: dividing the data into three data sets: a training set, an internal test set and an external test set; and 3, establishing a model, constructing an auxiliary diagnosis tool by using an Attention-Unet convolutional neural network, evaluating the risk, detection sensitivity, specificity and accuracy of the aortic aneurysm in a test set by using the auxiliary diagnosis tool. The method is reasonable in design and has good diagnosis capability on aortic aneurysm; when the method is used in combination with radiologists, the film reading and decision-making capabilities of the radiologists can be remarkably enhanced, and the overall strength of imaging departments is improved. Therefore, the performance of the advanced technology proves that the non-invasive, cheap and convenient method has the potential of clinical tests.