170 results about "Aortic rings" patented technology

The invention discloses an RSV infection immortalized tree shrew aorta vascular endothelial cell model, and particularly relates to a method for separating and culturing primary aorta vascular endothelial cells from tree shrew aorta, further establishing an immortalized tree shrew aorta vascular endothelial cell line, taking the cell line as an RSV virus culture medium, and constructing an RSV infection immortalized tree shrew aorta vascular endothelial cell model. Establishing an RSV infected immortalized tree shrew aortic vascular endothelial cell model, and preparing a high-infection-titer RSV virus; the invention provides key support for preparation and detection of RSV virus and construction of a tree shrew in-vivo infection model, provides a stable virus source for development of comparative medical research or vaccine evaluation, and has far-reaching significance for deep exploration of RSV pathogenic mechanism, drug and vaccine evaluation and the like.

The invention discloses a medical image segmentation method and system for an aortic dissection true cavity, an aortic dissection false cavity and an aortic dissection false cavity thrombus. The method comprises the following steps: firstly, acquiring three-dimensional medical image data of the aortic dissection, performing preprocessing operation on the image data to obtain a two-dimensional slice image, and performing local region division on the two-dimensional slice image; secondly, performing feature extraction on the divided image through a hierarchical feature extraction module; then, a dynamic region self-adaption module is used for carrying out region adjustment on the extracted feature map, a region response map is generated through a guide path, and explicit adjustment weights are given to different space regions in the feature map; and finally, uniformly aggregating the multi-scale feature maps after region adjustment, outputting a segmentation mask through a prediction module, and generating a segmentation result with a clear structural boundary and complete semantics. According to the method, while the recognition precision of the complex anatomical structure is improved, the detection capability and boundary sensing performance of a small-size focus are enhanced, and the method has good universality and stability.

The invention relates to the technical field of medical image analysis and processing, and discloses a complex aortic lesion intelligent analysis method and system and a storage medium. The method comprises the following steps: collecting a plurality of aorta images of multiple image types containing different lesion types, collecting lesion information as label information, and labeling the lesion aorta images based on the label information; extracting a lesion area and a key area, generating first training data and training a first recognition model; acquiring to-be-analyzed aortic images of multiple image types of a patient, performing enhancement processing, using a trained first identification model to identify each key region in the to-be-analyzed aortic images, acquiring a lesion score of each lesion type, calculating a first lesion score of each lesion type of the to-be-analyzed aortic images, and performing image processing on the to-be-analyzed aortic images according to the first lesion score; and determining a corresponding lesion type based on the first lesion score. According to the method, various image types can be effectively analyzed, and the recognition accuracy of aortic lesion types is improved.

The present invention relates to the technical field of medical devices, and discloses a special covered stent for in situ fenestration of an aortic arch, wherein the proximal end of the aortic covered stent is provided with 2-3 Z-wave stent rings (proximal Z-wave stent ring group) and 1 proximal small-wave stent ring, the distal end is provided with 3-4 Z-wave stent rings (distal Z-wave stent ring group), the middle section of the aortic covered stent is provided with a saddle-shaped metal stent ring, the aortic stent is fully covered with a coating, and the coating has a grid-like reinforcing wire. The special covered stent for in situ fenestration of an aortic arch mainly provides a special covered stent for in situ fenestration for in situ fenestration technology, which improves the success rate of fenestration and reduces the probability of stenosis caused by compression of the branch stent by the angle of the metal ring.

The invention discloses an aortic dissection assessment management method based on multi-source information coupling and related equipment. The method comprises the steps that face image information and electrocardio information of a target patient are obtained, wherein the electrocardio information comprises information collected by an ECG recorder; extracting evaluation association features in the face image information and the electrocardio information of the target patient so as to carry out embedding fusion; and performing aortic dissection risk assessment on the target patient based on the fusion features after embedding fusion. The problems that early evaluation and screening of the aortic dissection are difficult, invasive detection is needed, an existing evaluation source data set lacks diversity and is mainly manifested in the fact that covered patient groups are limited, most data sources are single center data, and complex pathological features of the aortic dissection cannot be comprehensively reflected can be solved.

A plain-scan CT image aortic valve calcification segmentation system based on space-time priori comprises a position priori information extraction module, an encoding module and a decoding module, after an aortic image is automatically segmented in an off-line stage to obtain a segmentation mask, attention weights are generated through preprocessing and encoding, and the aortic valve calcification is subjected to image segmentation; and inputting the aorta image serving as a training set into a segmentation model comprising a position prior information extraction module, a coding module and a decoding module, and performing real-time image segmentation through the trained segmentation model in an online stage. According to the method, calcification point features of different sizes and forms are captured through multi-scale prediction; the aorta segmentation prior is introduced, the sensitivity and positioning precision of the model to aortic valve calcification are improved, coronary artery opening sequence time sequence information is introduced, a double-branch structure is adopted to adapt to structural differences, accurate positioning and recognition of aortic valve calcification lesions are achieved, and the false detection rate and the omission ratio are effectively reduced.

The invention provides an application of human source circular RNA hsacirc0083796 in preparation of a diagnostic reagent or a medicine for diagnosing and / or treating aortic dissection. The invention also provides a kit for diagnosing the aortic dissection. The invention also provides a pharmaceutical composition for treating aortic dissection. According to the application of the human source circular RNA in preparation of heart disease related products, the related heart disease related circular RNA (circled-Frizzled class receptor 3, hsacirc0083796) is one of circular RNAs with the highest expression quantity in the blood of aortic dissection patients and has high conservative property, the function of the circular RNA is closely related to heart diseases, and the circular RNA has a good application prospect in preparation of heart disease related products. The method has great significance in diagnosis and treatment of heart diseases. Meanwhile, due to the stable and specific properties of the circular RNA, compared with other types of markers, the circular RNA has larger abundance in body fluid of a patient and more obvious change, so that the circular RNA has the potential of becoming a novel diagnostic marker.

An embodiment includes a system comprising: a backbone; a first polyurethane shape memory polymer (SMP) foam on the backbone; a second polyurethane SMP foam on the backbone; a third polyurethane SMP foam on the backbone and between the first and second SMP foams. Other embodiments are described herein.

The application provides an aortic covered stent, an in-situ fenestration instrument and a covered stent manufacturing method, and relates to the technical field of medical instruments.The aortic covered stent comprises a stent body and a covering film covering the stent body, the covering film in the fenestration area is divided into multiple layers and at least comprises an inner layer covering film and an outer layer covering film, and the inner layer covering film and the outer layer covering film are arranged in layers from the inner layer to the outer layer. The inner layer covering film and the outer layer covering film can adopt a lower weaving density, are easy to be punctured to break the film and expand the opening, and a sealing ring can be arranged between the inner layer covering film and the outer layer covering film; the branch stent, the inner layer covering film and the outer layer covering film are attached through surface contact from the inner layer to the outer layer, and the sealing ring is pressed between the inner layer covering film and the outer layer covering film, so that the sealing property is improved and the risk of internal leakage is reduced.

One embodiment includes a system comprising: a trunk; a first polyurethane shape memory polymer (SMP) foam on the trunk; a second polyurethane SMP foam on the trunk; and a third polyurethane SMP foam on the trunk and between the first SMP foam and the second SMP foam. Other embodiments are described herein.

An animal aortic plaque magnetic resonance imaging method and system based on a cardiac saturation band, relating to the technical field of magnetic resonance angiography. By means of a magnetic resonance scanner, a scout image of an animal is first acquired to determine a plaque imaging area and the position of a cardiac saturation band; once the cardiac saturation band has been located, respiratory gating is started to trigger collection of data, and by incorporating various magnetic resonance imaging techniques, an animal aortic plaque magnetic resonance imaging result is obtained. A high-resolution and high-contrast animal aortic plaque image can be rapidly acquired, reducing image artifacts. The present invention is suitable for basic and translational research on atherosclerosis model animals, can achieve non-invasive vascular wall structure imaging and composition analysis without applying a contrast agent, and can also implement in-vivo tracking of a new contrast agent and a drug.

The application discloses medical use of gelated cells loaded with sulfonated chitosan in treatment of atherosclerosis, and belongs to the technical field of biological medicine. The gelated cells loaded with sulfonated chitosan take macrophages as host cells, and intracellular cross-linking forms a photocrosslinking hydrogel network composed of methacrylated hyaluronic acid and sulfonated chitosan. The gelated cells completely retain cell membrane structure and membrane surface protein expression, lose the proliferation ability, and have excellent blood lipid selective adsorption capacity and foam cell lipid metabolism regulation capacity. In-vivo and in-vitro experiments prove that the gelated cells can significantly reduce blood lipid levels of atherosclerosis model animals, reduce aortic plaque area, and have good biological safety, thereby providing a new strategy and candidate drug for prevention and treatment of atherosclerosis, and having a good clinical application prospect.

Triphenylphosphonium hydroxytyrosol TPP-HT, its synthesis method and application in the preparation of drugs for improving aortic endothelial cell function. TPP-HT can significantly increase the reduction of human aortic endothelial cell activity caused by saturated fatty acids, inhibit the inflammatory response and oxidative stress caused by saturated fatty acids, and at the same time increase the synthesis of ATP in vascular endothelial cells and the expression of mitochondrial complex II. By anti-inflammatory and protecting mitochondrial function, it can prevent the occurrence and development of atherosclerosis. Therefore, TPP-HT has good application prospects in preventing cardiovascular diseases such as atherosclerosis caused by high-fat-induced endothelial damage, opening up a new medical approach for preventing a series of problems of cardiovascular diseases such as atherosclerosis caused by endothelial damage due to unbalanced dietary structure, and providing a new basis for the development of new drugs.

The present invention discloses a set of diagnostic markers for aortic dissection and their applications. The markers include the genes MMP8, ALOX15, HP, FXYD2, SIGLEC8, and CCL2. The genes MMP8, ALOX15, HP, FXYD2, SIGLEC8, and CCL2 protected by the present invention can be used as biomarkers for AD and as indicators for assessing disease severity in AD patients, enabling efficient diagnosis of patients with aortic dissection.

The invention discloses lipidosome nanoparticles, a preparation method thereof and application of the lipidosome nanoparticles in preparation of drugs for preventing and treating aortic dissection. According to the invention, the liposome is used as a carrier, DLX is wrapped in the carrier, and then the Col-IV targeting peptide is coupled to the surface of the liposome, so that the liposome nanoparticles can be obtained. The liposome nano-particle delivers drugs in a targeted manner, and brings a new hope for intervening the aortic dissection of a mouse. The mouse interlayer occurrence rate and the death rate are greatly reduced.

The invention discloses an application of isoginkgetin or pharmaceutically acceptable salts thereof in preparation of SETD1A small molecule activity inhibitors and drugs for preventing and / or treating vascular injury diseases. According to the invention, the small-molecule inhibitor isoginkgetin taking SETD1A as an intervention target and the pharmaceutical application of the small-molecule inhibitor isoginkgetin are confirmed for the first time. Isoginkgetin can inhibit the modification function of SETD1A under the condition of not influencing the expression quantity of SETD1A, and can improve PDGF-induced phenotype transformation of human aortic smooth muscle cells; intimal neogenesis caused by vascular injury can be obviously relieved; the myocardial fibrosis can be improved.

The invention discloses gamma-aminobutyric acid and application of a pharmaceutical composition thereof in preparation of drugs for preventing or treating aortic dissection and aortic aneurysm. The invention provides the application of gamma-aminobutyric acid in preparation of drugs for preventing or treating aortic dissection for the first time, and verifies the application of gamma-aminobutyric acid in preparation of drugs for preventing and / or treating aortic dissection and aortic aneurysm by inhibiting endothelial cell dysfunction; the application of gamma-aminobutyric acid in preparation of drugs for preventing and / or treating aortic dissection and aortic aneurysm by inhibiting expression of c-FOS to reduce vascular endothelial cell injury is verified; the application of gamma-aminobutyric acid in preparation of drugs for preventing and / or treating aortic dissection and aortic aneurysm by reducing infiltration of macrophages is verified.

The invention relates to a computer-implemented method (100) for generating patient- specific templates of aortic leaflets comprising: - generating (104) a 3D model from digital images (102) of a native aortic root and aortic leaflets of a patient; - generating (106) 3D neo-leaflets models by simulating in silico aortic leaflet neocuspidization from the 3D model with parameters of developable coaptation surfaces and of non-developable load-bearing surfaces of aortic leaflets; - realizing (108) a 2D surface flattening of the coaptation surfaces of the 3D neo- leaflets models; - realizing (110) a 2D surface flattening of the load-bearing surfaces of the 3D neo- leaflets models; - merging (112) a 2D coaptation surface with a 2D load-bearing surface for each neo- leaflet model; and - generating (114) a patient-specific template for each aortic leaflet.

A method of providing support in an aortic region. The method includes wrapping a landing band around an outside of a portion of an aortic vessel in a vicinity of a sinotubular junction (STJ) to form a wrapped portion of the aortic vessel. The method further includes securing the landing band to form a secured landing band. The method also includes endovascularly delivering a stent graft in a radially constricted configuration into the aortic vessel. The method also includes deploying the stent graft to a radially expanded configuration such that the stent graft contacts the wrapped portion of the aortic vessel. The method also includes connecting the stent graft in the radially expanded configuration to the secured landing band.

The invention relates to an application of loratadine in preparation of drugs for preventing and treating vascular calcification. The structural formula of the loratadine is as follows: # imgabs0. The loratadine used in the invention can significantly reduce the level of mouse aortic vascular calcification, and the experimental result proves that the loratadine has the effects of preventing and treating vascular calcification. The medicine disclosed by the invention is relatively low in toxicity and relatively high in safety.

The present invention provides a method, system, device, medium and program product for constructing a tubular feature prediction model, and relates to the field of intelligent medical care. The method includes: obtaining paired NCE-CT and CE-CT images of aortic dissection in a training set sample; high-scale features and low-scale features of tubular structures in the NCE-CT images; obtaining an offset based on the high-scale features; guiding the position offset of the low-scale features based on the offsets, inputting the values ​​of the low-scale features after position offset and the offsets into a multi-head self-attention network for fusion to obtain tubular feature data; obtaining a student model classification result based on the tubular feature data; adjusting the pre-trained large model based on the CE-CT images to obtain a teacher model, and obtaining a corresponding teacher model classification result; optimizing the student model based on the teacher model classification result and the student model classification result, using knowledge distillation to obtain a constructed student model, which is the prediction model.

The invention provides a biomarker composition and an application thereof. The biomarker composition comprises the following proteins: MMP12, UMOD, HbA1c, FGF9, NINJ1 and PRSS8. According to the biomarker composition provided by the invention, through combination of matrix metalloproteinase 12, uromodulin, glycosylated hemoglobin, FGF9, NINJ1 and serine protease 8, the problem of lack of a specific marker for aortic wall structure damage in the prior art is solved.

The invention discloses an application of an NRF2 signal channel activator in preparation of a medicine for preventing or treating hyperuricemia-related atherosclerosis, relates to the technical field of medicines, and particularly relates to an application of the NRF2 signal channel activator in preparation of a medicine for preventing or treating hyperuricemia-related atherosclerosis. The NRF2 signal channel activator is used for up-regulating NRF2 protein expression or enhancing transcriptional activity of the NRF2 protein; the NRF2 signal channel activator is used for up-regulating expression of a downstream target gene SLC7A11 and / or GPX4 so as to inhibit ferroptosis of hyperuricemia aortic macrophages; the level of glutathione (GSH) in serum is increased; the malondialdehyde (MDA) and / or iron ion (Fe < 2 + >) level in serum is reduced; nRF2 signal channel activation and macrophage ferroptosis inhibition are associated, and the NRF2 signal channel is applied to prevention and treatment medicines for hyperuricemia-related atherosclerosis, so that development of specific treatment medicines for patients suffering from hyperuricemia-related atherosclerosis is facilitated.

The invention discloses a method for detecting aortic dissection through peripheral blood BRD4 based on flow cytometry and application. The invention belongs to the technical field of biology, and particularly relates to a method for detecting aortic dissection through peripheral blood BRD4 based on flow cytometry and application. The method for detecting the content or expression level of the bromodomain-containing protein 4 in the sample to be detected comprises the following steps: 1) treating the sample to be detected to obtain mononuclear cells; the method comprises the following steps of (1) determining a mononuclear cell, (2) determining a fluorescein coupling antibody composition of a detection index according to a flow cytometry color matching scheme, (3) uniformly mixing the mononuclear cell in the step (1) and the fluorescein coupling antibody in the step (2), incubating in a dark place and dyeing, (4) loading and testing a sample by a spectrum flow cytometry, and (5) analyzing a data result, and the detection indexes in the step (2) are CD45, CD11B, CD66B, CD14, CC16 and BRD4.

The invention provides application of a detection reagent of an exosome or extracellular envelope derived biomarker in preparation of a composition or a kit for evaluating, diagnosing, screening and / or monitoring an aortic dissection of a subject. The exosome or extracellular envelope derived biomarker provided by the invention is applied to detection, and has high sensitivity and specificity. Compared with the traditional method, the reaction time is greatly shortened. Good clinical application prospects are realized.

A support ring for an aortic prosthesis includes a helical coil extending in an arc and defining a space between a helical coil first end and helical coil second end in opposing relation to each other. A wire extending through the lumen defined by the helical coil includes a wire first end and a wire second end that are fixed to each other, and a length between the wire first end and the wire second end that traverses the space between helical coil first end and the helical coil second end. A branch sleeve assembly includes a graft sleeve having a proximal end that defines a plane that intersects a plane defined by the distal end of the graft sleeve, and a support ring fixed to the graft sleeve wall that is closer to the proximal end of the graft sleeve than to the graft sleeve distal end.

The present application discloses a method and device for obtaining aortic dissection images based on non-enhanced CT images. The method for obtaining aortic dissection images based on non-enhanced CT images includes: obtaining original image information; obtaining a preprocessing feature matrix according to the original image information; inputting the preprocessing feature matrix into a two-stage cascaded calcification inward migration recognition network to obtain a calcification inward migration recognition image; inputting the preprocessing feature matrix into an intimal flap recognition network to obtain an intimal flap recognition image; and inputting the preprocessing feature matrix into a pseudo-CTA image generation network to obtain a pseudo-CTA image. Through the method for obtaining aortic dissection images based on non-enhanced CT images of the present application, the layer and location where the dissection is located can be clearly indicated, assisting doctors in quickly confirming whether the NCCT-related layer contains a suspected dissection.

The application discloses an aortic dissection identification method and related device, which can be applied to the technical field of deep learning, extracts local features of a to-be-identified heart ultrasound image, and the local features are aortic region features. The local features of the to-be-identified heart ultrasound image are input into a trained dissection classification model to obtain a classification result output by the dissection classification model, and the classification result is used to indicate whether an aortic dissection exists in the to-be-identified heart ultrasound image. A support set at least includes local features of a first type of heart ultrasound image, the first type of heart ultrasound image is a heart ultrasound image with an aortic dissection, and a classification label is a classification result artificially annotated to indicate whether an aortic dissection exists. The classification accuracy of the dissection classification model trained based on the feature similarity between the local features of the to-be-identified heart ultrasound image and the local features of the heart ultrasound image with the aortic dissection is high, and thus, the classification result accuracy is improved.

The invention discloses pharmaceutical application of RNA helicase DHX8, including application of the RNA helicase DHX8 in aortic dissection diagnosis, treatment and drug development. It is found for the first time that DHX8 is significantly down-regulated in aortic dissection patients, animal models and vascular endothelial cells, and overexpression of DHX8 can effectively up-regulate endothelial cell tight connection related genes and repair the endothelial barrier function. The Si DHX8 is used for transfecting human umbilical vein endothelial cells (HUVECs), and the DHX8 is knocked down, so that the tight connection gene OCLN is obviously reduced; when the OE DHX8 plasmid is used for transfecting the HUVECs and overexpressing the DHX8, the tight connection genes OCLN, JAM-A, ZO-1 and VE-cadherin are found to be obviously up-regulated. The DHX8 is used as a new target for aortic dissection diagnosis and treatment, and a detection reagent, a gene therapy vector and an agonist drug of the DHX8 have important clinical transformation values.

The invention relates to the field of diagnostic reagents, in particular to a dual-marker dual-mode quantitative detection probe, a preparation method thereof and application of the dual-marker dual-mode quantitative detection probe in aortic dissection diagnosis. Compared with a traditional probe, the dual-marker dual-mode quantitative detection probe has the advantages that fluorescence-magnetic resonance relaxation dual-mode signals do not interfere with one another, and synchronous quantification can be achieved. The application advantage in aortic dissection diagnosis is that the detection rate of the aortic dissection can be remarkably improved by simultaneous detection of the double markers, and misdiagnosis generated during detection of a single marker is avoided. Meanwhile, double indexes can be obtained through single detection, repeated sampling is avoided, and the detection time is effectively shortened.