A Stanford A type aortic dissection animal model and a method for manufacturing the same

An aortic dissection and animal model technology, which is applied in medical science, veterinary instruments, veterinary surgery, etc., can solve the problem of long time for aortic dissection production, reduce the probability of animal death from hemorrhagic shock, and improve the success rate. , the effect of shortening the production time

Inactive Publication Date: 2016-01-13
THE FIRST TEACHING HOSPITAL OF XINJIANG MEDICAL UNIVERCITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The present invention provides a Stanford type A aortic dissection animal model and its production method, which overcomes the above-mentioned deficiencies in the prior art, and can effectively solve the existing problems in construction. In the process of Stanford type A aortic dissection animal model, there is a problem that the production time of aortic dissection is long

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  • A Stanford A type aortic dissection animal model and a method for manufacturing the same
  • A Stanford A type aortic dissection animal model and a method for manufacturing the same
  • A Stanford A type aortic dissection animal model and a method for manufacturing the same

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Embodiment 1

[0030] Embodiment 1: The Stanford type A aortic dissection animal model is obtained according to the following manufacturing method: first step, establish a venous channel for the animal, anesthetize and disinfect the animal, and perform a thoracotomy on the animal to expose the ascending aorta of the animal; In the second step, the distal end of the ascending aorta root of the animal is clamped along the lower side wall of the blood vessel to block part of the ascending aorta lumen, and then the adventitia and media of the ascending aorta wall of the animal are cut longitudinally The incision depth of the media of the ascending aorta wall of the animal is two-fifths to one-half of the thickness of the media of the ascending aorta wall of the animal; The medial space is found in the media, and the medial space is bluntly dissected to expand the medial space to the surroundings. From the medial space after blunt dissection, the wall of the ascending aorta of the animal is conti...

Embodiment 2

[0031] Embodiment 2: The Stanford type A aortic dissection animal model is obtained according to the following manufacturing method: first step, establish a venous channel for the animal, anesthetize and disinfect the animal, and perform a thoracotomy on the animal to expose the ascending aorta of the animal; In the second step, the distal end of the ascending aorta root of the animal is clamped along the lower side wall of the blood vessel to block part of the ascending aorta lumen, and then the adventitia and media of the ascending aorta wall of the animal are cut longitudinally The incision depth of the media of the ascending aorta wall of the animal is 2 / 5 or 1 / 2 of the thickness of the media of the ascending aorta wall of the animal; The medial space is found in the media, and the medial space is bluntly dissected to expand the medial space to the surroundings. From the medial space after blunt dissection, the wall of the ascending aorta of the animal is continued to be ...

Embodiment 3

[0032] Example 3: The Stanford type A aortic dissection animal model was obtained according to the following manufacturing method: first step, establishing a venous channel for the animal, anesthetizing and disinfecting the animal, and performing a thoracotomy on the animal to expose the ascending aorta of the animal; In the second step, the distal end of the ascending aorta root of the animal is clamped along the lower side wall of the blood vessel to block part of the ascending aorta lumen, and then the adventitia and media of the ascending aorta wall of the animal are cut longitudinally The incision depth of the media of the ascending aorta wall of the animal is two-fifths of the thickness of the media of the ascending aorta wall of the animal; the third step is to find the media in the media of the ascending aorta wall of the animal The intermembrane space is bluntly dissected the media space to expand the media space to the surroundings, and continues to incise the uncut...

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Abstract

The invention relates to the technical field of aortic dissection animal models and methods for manufacturing the same and provides a Stanford A type aortic dissection animal model and a method for manufacturing the same. Compared with the conventional method for manufacturing a Stanford A type aortic dissection animal model, the method for manufacturing a Stanford A type aortic dissection animal model, which is provided by the invention, has the advantages that the time for manufacturing the ascending aortic dissection is reduced and the success rate of manufacture of the Stanford A type aortic dissection animal model is increased. Meanwhile, the control to the false lumen length of the Stanford A type aortic dissection animal model lays an experiment foundation for the investigation of the Stanford A type aortic dissection pathogenesis and new therapeutic methods.

Description

technical field [0001] The invention relates to the technical field of an aortic dissection animal model and a manufacturing method thereof, and relates to a Stanford type A aortic dissection animal model and a manufacturing method thereof. Background technique [0002] Aortic dissection occurs when blood enters the aortic wall through an intimal tear in the aorta and causes separation of the normal arterial wall. Aortic dissection (AD) is a sudden, life-threatening cardiovascular disease. Its annual incidence rate is 2.9 to 3.5 cases per 100,000 people, with a high fatality rate. Without treatment, about half of the cases died within 48 hours after onset, and about two-thirds of the cases died within one week after onset. Generally, human arterial vessels are composed of three layers, namely intima, media and adventitia, and the three layers are closely attached to carry the passage of blood flow together. Stanford type A aortic dissection refers to acute aortic dissecti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61D1/00A01K67/027
CPCA61D1/00A01K67/027A01K2227/108A01K2267/03A01K2267/0375
Inventor 马翔马依彤孟凡华安勇王宝珠姜涛汪浩
Owner THE FIRST TEACHING HOSPITAL OF XINJIANG MEDICAL UNIVERCITY
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