118results about How to "Ability to inhibit migration" patented technology

The present invention relates to a solid rocket engine propellant lining layer material and a preparation method thereof, and belongs to the field of solid rocket engine lining layer material preparation. According to the present invention, azido-terminated polybutadiene is adopted as a polymer prepolymer, a multi-alkynyl compound is adopted as a curing agent, a plasticizer, a solid filler and a process auxiliary agent are added, and an inter-azido/alkynyl click chemistry reaction is used to prepare the triazole five-membered ring cross-linked low-polarity polybutadiene lining layer material, such that the migration performance of the polar nitrate plasticizer of the NEPE composite propellant in the lining layer material is effectively inhibited; and the obtained solid rocket engine propellant lining layer material can be subjected to curing molding within the temperature of 50-70 DEG C, the reaction conditions are mild, the obtained lining layer material has low polarity, the disadvantages of the propellant lining layer material preparation through the cross-linking of polyurethane and polybutadiene are overcome, and the propellant lining layer material preparation method is broadened.

The invention discloses a strain of phosphate-solubilizing bacteria which is preserved in China general microbiological culture collection center (CGMCC) and is named as enterobacter agglomerans RKMC-7 in a classification way with the preservation number of CGMCC No. 5005. After a bactericide containing the enterobacter agglomerans is inoculated into the soil polluted by lead, the exchangeable form lead can be promoted to be fixed, and the fixing efficiency is 77-91.4%. The bactericide is simple in preparation method, rich in material source and easy in implementation of large-scale production, can realize the effect of carrying out agricultural production while repairing, and has important significance for guaranteeing grain safety and environmental protection.

There is provided a semiconductor device that suppresses the occurrence of resin burrs and has favorable electrical connectivity and bond strength, and a manufacturing method for such semiconductor device. A resin-coated metal part is manufactured by forming an organic coating by depositing a material including functional organic molecules on a wiring lead composed of a metallic material. Each of the functional organic molecules includes a main chain, a first functional group having a metal bonding property, and a second functional group. The first functional group and the second functional group are provided at different ends of the main chain. Thereafter the functional organic molecules self-assemble by bonding of the first functional groups to metal atoms of the wiring lead. After performing the organic coating formation step, resin is adhered to a predetermined surface area of the wiring lead having the organic coating formed thereon.

The invention discloses (6S)-3-acetyl-4-oxo-4,6,7,12-tetrahydroindolyl[2,3-a]quinolizin-6-formyl-Tyr-Ile-Gly-Ser-Arg with a structure represented by a formula shown in the description. The normal abbreviation of Tyr-Ile-Gly-Ser-Arg is YIGSR. The invention discloses a preparation method therefor, a nanostructure thereof, antitumor action thereof, antitumor cell adhesion invasion and migration actions thereof and explains application thereof in medicine.

The invention discloses (6S)-3-acetyl-4-oxo-4,6,7,12-tetrahydroindole [2,3-a] quinolizine-6-formyl-Arg-Gly-Asp-Ser structured as follows, wherein the standard abbreviation of Arg-Gly-Asp-Ser is RGDS. The invention discloses a preparation method therefor, a nanostructure thereof, antitumor action thereof and action thereof in resisting adhesion, invasion and migration of tumor cells, and illustrates application thereof in medical science. The formula is shown in t he description.

The invention provides a fluorene photoinitiator and a photocured composition comprising same. A compound a reacts with a compound b, so that the fluorene photoinitiator is prepared, i.e., the fluorene photoinitiator is obtained by the chain extension reaction between R2 and/or R4 in the compound a shown as formula (I) and the olefinic double-bond compound b containing a substituent group. The fluorene photoinitiator disclosed by the invention not only has excellent photoinitiating activity, but also has the advantages of almost no small-molecule residue, excellent solubility and the like. Theformula (I) is shown in the description.

The invention relates to a polypeptide and chemotherapy drug combined drug-loaded micelle and a preparation method and an application thereof. Polypeptide with a tumor targeting therapeutical effect and a chemotherapy drug are combined to prepare the tumor-targeting polypeptide-PEGylated phospholipid complex-chemotherapy drug drug-loaded micelle; the polypeptide with the tumor targeting therapeutical effect is specifically combined with a chemotactic factor receptor CXCR4, the CXCR4 polypeptide antagonist is used for increasing a targeting penetration ability of the drug to tumor tissues, the PEGylated phospholipid micelle is used for increasing the drug biological stability and the drug loading amount, and compared with a single chemotherapy drug doxorubicin, the combined drug-loaded micelle shows a stronger characteristic of inhibiting tumor cell vitality. The polypeptide and chemotherapy drug combined drug-loaded micelle provides a feasible method and technique for improving the tumor therapeutic effect.

The invention provides lung adenocarcinoma exosome specific miRNAs, and a target gene and applications thereof. High flux sequencing technology is combined with systematic bioinformatics analysis methods, the specific high-content exosome miRNAs related with lung adenocarcinoma is obtained through screening; the RNA sequences of the lung adenocarcinoma exosome specific miRNAs are represented by SEQ ID No.1-3. It is found that the common target gene of the miRNAs is FOXN3. The target gene is capable of inhibiting fibroblast migration capability, reduction of the expression amount of the targetgene is capable of promoting entering of fibroblast into tumor tissues, and promoting tumor growth. The lung adenocarcinoma exosome specific miRNAs and the target gene thereof can be taken as lung adenocarcinoma diagnosis markers and can be used for preparation of diagnostic kits. An inhibitor of the miRNAs or an expression promoter of the target gene can be used for preparing medicines used for treating lung adenocarcinoma, or medication guidance in treatment of lung adenocarcinoma; and the clinical application value is relatively high, and the application prospect is promising.

The invention discloses a preparation method of a heat stability-enhanced porous silver-magnesium-aluminum alloy film, and relates to the technical field of photoelectric materials. The preparation method comprises the following steps: firstly preparing a silver-magnesium-aluminum alloy film through a thin film deposition technology, wherein the silver-magnesium-aluminum alloy film is prepared from the following chemical components in percentage by mass: 50 to 60 percent of a magnesium element, 3 to 10 percent of an aluminum element and 30 to 47 percent of a silver element; and then corroding active metals through dealloying reaction liquid, thus forming a nano porous structure which takes silver as a framework and is doped with a little of aluminum and magnesium. After being subjected to high temperature treatment, the porous silver-magnesium-aluminum alloy film prepared through the preparation method still can keep the porous structure, so that a relatively wide absorption spectrum and a relatively good absorption effect can be kept. The preparation process is simple, the repetitiveness is high, and the cost is low; the shortcoming in the heat stability of a porous silver-based film in the prior art can be overcome; and actual popularization and application of the porous silver-based film are facilitated.

The invention discloses a lovastatin silicon plastid of a targeted breast cancer stem cell and a preparation method thereof.The lovastatin silicon plastid is prepared from, by weight, lovastatin 2%-30%, organic-inorganic compound lipid 20%-70%, phosphatidyl ethanolamine-polyethylene glycol 2000 1%-20% and distearoyl phosphatidylcholine 10%-60%.The lovastatin silicon plastid overcomes the shortcoming that the bioavailability of lovastatin drugs in the prior art is low.

The invention discloses 1-(4-isopropyl propyl)-beta-carboline-3-formyl-Trp-Trp-Trp-Lys-Glu structured as follows, a preparation method therefor, a nanostructure thereof, antitumor action thereof, action thereof in resisting adhesion and invasion and migration of tumor cells, and illustrates application thereof in medical science. The formula is shown in the description.

The invention discloses a long chain noncoding RNA marker for auxiliary diagnosis of colorectal cancer (CRC). Long chain noncoding RNA is HOTAIR; auxiliary diagnosis or prediction of patient conditiondevelopment of the CRC can be realized by detecting expression quantity of the long chain noncoding RNA; differentiation, infiltration depth, proliferation and metastasis conditions of the CRC can bepredicted by monitoring expression conditions of p21 and a value of judging prognosis is realized. Expression level of LncRNA HOTAIR gene can be detected by RT-qPCR, real-time quantitative PCR, immunodetection, in-situ hybridization, chip or a high-throughput sequencing platform; meanwhile, the invention also discloses silencing HOTAIR which can obviously inhibit the proliferation, migration andinvasion abilities of CRC cells, reduce the expression of PCNA, Ki67, cyclin E and CDK2 and medicate expression increase of p21. The invention provides a molecular marker for the CRC and provides theoretical basis for mechanism research and clinical individualized therapy of the CRC; a brand-new treatment strategy can be provided for clinically treating the CRC by monitoring the expression of theLncRNA HOTAIR in the CRC.

The invention discloses nanofiber which comprises a nanofiber body prepared from a mixture through a static spinning process. The mixture comprises a precursor solution of a perovskite structure material and a nano conductive material doped in the precursor solution. The invention further discloses a preparation method of the nanofiber and the embedded capacitive material comprising the nanofiber.When the nanofiber is applied in the embedded capacitive material, dielectric constant and no increase of dielectric loss are ensured; by adding conductive particle filler, interface polarization canbe effectively improved, and migration ability of charge inside polymer can be inhibited; under externally-applied field intensity, polarization degree of a composite material is increased, and puncture field intensity and comprehensive performance of the composition material are improved.

The invention relates to Trp-Trp-Trp decapeptide modified beta-carboline, discloses a preparation method and the nanometer structure of beta-carboline, relates to the in-vivo and in-vitro antitumor effects of beta-carboline, and relates to effects of beta-carboline to resist tumor cell adhesion invasion and migration. Therefore, the invention discloses application of Trp-Trp-Trp decapeptide modified beta-carboline to prepare antitumor medicines and prepare medicines resisting tumor cell adhesion invasion and migration. The invention belongs to the field of biological medicine.

The invention discloses a compound used as an estrogen-related receptor regulator and an application of the compound. The compound is a 1-hydrogen-1, 2, 3-triazole compound with a structure as shown in formula (I) as well as pharmaceutical acceptable salt or prodrug molecule. The compound as well as pharmaceutical acceptable salt or prodrug molecule can be used for preparing drugs for adjusting activity of estrogen relevant receptor (ERR), preventing and treating breast cancer (comprising diseases which are free of influence of an anti-estrogen method), prostatic cancer or metabolic diseases. The formula (I) is as shown in the specification.

The invention discloses an application of a polypeptide Kp-10 in preparation of a medicine for treating and preventing osteosarcoma. The amino acid sequence of the polypeptide Kp-10 is DSSDSSDSSDSSDSSDSSYNWNSFGLRF. Researches find that expression of GPR54/KiSS-1 in osteosarcoma tissues is obviously lower than that in normal tissues beside the tumor tissues, and is highly related to clinical prognosis, and the polypeptide Kp-10 and a receptor GPR54 of the polypeptide Kp-10 can inhibit proliferation and migration capacity and lung metastasis capacity of osteosarcoma cells, so that the polypeptide Kp-10 can be used for preparing medicines for treating and preventing osteosarcoma, and a new thought is provided for exploration of osteosarcoma targeted medicine.

The invention belongs to the field of application of traditional Chinese medicine, and particularly relates to application of a Babao pill in preparation of medicines for inhibiting malignant development of stomach cancer. The malignant development of the stomach cancer comprises the recurrence of the stomach cancer and the transfer and diffusion of stomach cancer cells. The Babao pill has good development and application prospect, and the novel application is disclosed for the first time. The Babao pill mainly is prepared from the following components of calculus bovis, snake gall, antelope horn, pearl powder, radix notoginseng and musk.

The invention provides Zyxin gene shRNA inhibiting tumor cell proliferation and migration, a recombinant vector and application, and particularly relates to shRNA specifically silencing a Zyxin (ZYX)gene. A silencing vector of the Zyxin gene is constructed. A shRNA fragment is designed first based on the human Zyxin gene sequence, the synthesized fragment has suitable restriction sites at both ends, and the target fragment is connected to a lentiviral vector to form the core silencing vector. The constructed shRNA vector can significantly inhibit the expression of the Zyxin gene at the protein level. Furthermore, a lentivirus is used as a vector carrying shRNA, and the vector can introduce the shRNA sequence directed at the Zyxin gene into colorectal tumor cells in a targeted manner and significantly inhibit the proliferation and migration capability of the colorectal tumor cells.

The invention discloses an application of salvianolic acid A in preparing an anti-tumor metastasis medicine. The invention has the importance of discovering that the salvianolic acid A in salvia miltiorrhiza has notable inhibiting effect on tumor metastasis, has obvious influence on the tumor metastasis related gene and protein, can selectively inhibit proliferation of tumor cells, and has safety and low toxicity to normal cells of the human body, so that the salvianolic acid A has application prospects in preparing the anti-tumor metastasis medicine.

The invention provides application of JAM-A (Junctional Adhesion Molecules A) protein to treatment on RA (Rheumatoid arthritis). The JAM-A whose the expression quantity in peripheral blood lymphocytes of an RA patient is higher than that of a normal healthy person are authenticated; the condition that the JAM-A takes part in the peripheral blood lymphocyte migration regulation in the functional aspect is proved; and the migration of immune lymphocytes to peripheral bones and joints can be effectively weakened, so that the effect of treating the RA is achieved. The identical treatment effect is achieved in a mouse CIA (Collagen Induced Arthritis) animal model. The invention provides a therapeutic molecular target for the clinical intervention on clinic RA patients.

The invention discloses a method for in-situ remediation and utilization of open water body bottom sludge biomass. An ecological revetment constructed through ecological gabions is included; pebble cushion layers and composite sludge layers are sequentially and alternately laid at the bottom of the space between the ecological revetment and a water body bank from bottom to top, wherein the composite sludge layers are formed by mixing bottom sludge in an open water body, microbial agents and chemicals; a vertical porous exhaust pipe is arranged in the bottommost composite sludge layer, a planting soil layer is laid on the uppermost composite sludge layer, and the upper end of the porous exhaust pipe extends to the upper side of the planting soil layer; a vegetation layer is planted on the planting soil layer. A physical-chemical-biological combined treatment technology is used, green landscapes are created during bottom sludge remediation, the remediation period is short, and the methodtakes effect quickly.

The invention discloses a preparation method and application of an antitumor protein, and belongs to the technical field of biological medicines. According to the invention, a protein shown in SWQ IDNO.1 is screened and verified to be applied to resistance to tumor for the first time; and a CCK8 (Cell counting kit-8) proliferation experiment result shows that a PvEXP100 protein can remarkably inhibit the proliferation of a HepG2 cell, and the inhibition rate is up to 80.1%, so that the migration performance of the HepG2 cell is almost completely inhibited. The PvEXP100 protein involved in theinvention, as an active ingredient or a raw material, can be prepared into an antitumor medicine, and has a wide application prospect.

The invention discloses 1-(4-isopropylphenyl)-[beta]-carboline-3-formyl-Trp-Trp-Trp-Leu-Asp-Val, a preparation method, a nano structure and an anti-tumor effect of the compound, an effect of the compound of inhibiting adhesion, invasion and migration of tumor cells and an application of the compound in medicine.

The invention discloses a new function of magnetic field constraint equipment. The new function is specifically that the magnetic field constraint equipment is applied to A) preparation of a product for inhibiting tumor metastasis, and B) preparation of a product for inhibiting tumor cell migration. Experiments prove that under a magnetic field constraint condition (0-5 muT), migration ability ofbreast cancer cells and metastasis of breast cancer solid tumors are inhibited obviously; the magnetic field constraint condition is a physical environment that is easy to simulate, so that treatmentof tumours can be realized very conveniently; and since a magnetic field can penetrate biological tissue, noninvasive treatment can be realized. The method not only can reduce malignant grade of tumours, but also can provide a simple and non-invasive treatment environment.

The invention discloses application of millet bran active polyphenol in preparation of a product for preventing and treating atherosclerosis. Experiments prove that the millet bran active polyphenol can significantly inhibit migration ability of human aortic smooth muscle cells, can significantly inhibit lipid phagocytosis ability of the human aortic smooth muscle cells and human mononuclear macrophages, and can inhibit formation of in-vivo atherosclerotic plaques, thereby preventing and treating atherosclerosis. The millet bran active polyphenol is taken as a main component and can be used for preparing functional foods or medicines for preventing and/or treating atherosclerosis.