Application of CDH18 gene as target spot in screening medicine for preventing or treating cervical cancer
By targeting the CDH18 gene and using drugs such as kaempferol to inhibit the proliferation and migration of cervical cancer cells, the problem of lacking effective targets in existing technologies has been solved, and effective treatment of cervical cancer has been achieved.
CN121899407AInactive Publication Date: 2026-04-21SHIHEZI UNIVERSITY
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Patent Information
- Application Number
- CN202610082873.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-01-21
- Publication Date
- 2026-04-21
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
Technical Problem
Current technologies lack effective targets for the treatment of cervical cancer, especially the application of the CDH18 gene in cervical cancer drug screening has not been fully studied, resulting in unsatisfactory treatment outcomes for advanced and recurrent cervical cancer.
Method used
利用CDH18基因作为靶点,通过抑制或沉默CDH18基因的表达,使用shRNA、siRNA、dsRNA、miRNA、cDNA、反义RNA/DNA、低分子化合物、肽、抗体等药物,特别是山奈素,调控Wnt信号途径以抑制宫颈癌细胞的增殖和迁移。
Benefits of technology
Inhibiting CDH18 gene expression can significantly suppress the proliferation and migration of cervical cancer cells. Kaempferol slows tumor growth by reducing CDH18 gene expression levels and has significant anti-tumor activity, showing good efficacy in both in vivo and in vitro experiments.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention relates to the technical field of biology, in particular to application of a CDH18 gene serving as a target spot to screening of drugs for preventing or treating cervical cancer, the drugs take the CDH18 gene as the target spot, expression of the CDH18 gene is inhibited or silenced, the proliferation and migration capacity of cervical cancer cells can be enhanced by regulating and controlling a Wnt pathway through overexpression of the CDH18 gene, and the drugs for preventing or treating cervical cancer can be used for preventing or treating cervical cancer. The down-regulation of the CDH18 gene inhibits the expression of beta-catenin, the knock-down of the CDH18 gene can inhibit the proliferation and migration ability of cervical cancer cells by regulating and controlling a Wnt signal pathway, the kaempferide has a certain potential anti-tumor activity effect in the cervical cancer cells, the kaempferide can induce the apoptosis of SiHa and HeLa cells of cervical cancer, and the kaempferide can inhibit the proliferation and migration ability of the cervical cancer cells. Experiments show that the kaempferide inhibits the expression level of Wnt signal pathway related molecules by reducing the expression level of CDH18, further promotes apoptosis of cervical cancer cells and inhibits proliferation and migration of the cervical cancer cells.
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