11 results about "Radiation Enteritis" patented technology

The application relates to application of iron-nitrogen doped graphene in preparation of anti-radioactive enteritis drugs and belongs to the technical field of biological medicines. ZIF-8 powder, 1,10-phenanthroline powder, iron (II) acetate powder and a grinding medium are placed in a closed container to perform mechanical ball milling treatment to obtain a mixed powder; under the protection of inert gas, the mixed powder is placed in a preheated tube furnace to perform pyrolysis treatment, and is cooled to room temperature to obtain iron-nitrogen doped graphene. The iron-nitrogen doped graphene has NADH oxidase-like activity, can directly catalyze the conversion of NADH into NAD + , can rapidly supplement NAD + depletion caused by radiation, can enhance PARP-dependent DNA damage repair, can reduce the generation of active oxygen (ROS), can reduce intestinal cell death and can protect the integrity of intestinal structure, and can realize efficient protection of radioactive enteritis. Moreover, the problem of low-efficiency biosynthesis of NAD + supplementation in existing radioactive intestinal injury protection technologies is solved.

The invention discloses bigeminal probiotic resistant dextrin / xanthan gum gel and application thereof in prevention and treatment of ionizing radiation damage. The bigeminy probiotics comprise lactobacillus reuteri and bacillus coagulans. When the two prebiotics xanthan gum and the resistant dextrin are combined to form the gel, the probiotics can be well loaded, the probiotics are protected from being damaged by gastric acid, the probiotics can stay for a long time after reaching the intestinal tract, the effect of the probiotics in the gel can be fully played, and meanwhile, the prebiotics can also fully play the role. The bigeminal probiotic resistant dextrin / xanthan gum gel can be used for preventing and treating ionizing radiation induced hematopoietic system injury and radiation enteritis.

The invention relates to and discloses a radiation enteritis prevention method based on an AI model and image fusion, which aims at the difficulty in prediction and intervention of radiation enteritis after radiotherapy of abdominal and pelvic tumors, predicts to be incorporated into 100 radiotherapy patients through historical retrospective and prospective prediction, systematically collects multi-modal data, carries out image fusion on the multi-modal data, and carries out image fusion on the multi-modal data. Utilizing interpretable machine learning to fuse radiomics parameters, flora markers and clinical variables, constructing a radiation enteritis dynamic risk prediction model, and verifying the universality of the model through 200 historical queues; key flora / metabolic targets are further screened, a coprophilous fungi transplantation intervention scheme is designed, the regulation and control effect of coprophilous fungi is verified in 50 high-risk patients, an AI auxiliary decision-making system and a microecological preparation are finally developed, a full-chain management strategy of'image-omics prediction-targeted intervention-clinical transformation 'is formed, and an innovative solution is provided for precise prevention and control of radiotherapy complications.

The invention provides application of cordate houttuynia extracellular vesicles in preparation of a medicine for treating radiation enteritis. As a vesicle structure containing lipid, protein, miRNA and active small molecules, the exosome disclosed by the invention has a multi-target regulation effect; the cordate houttuynia is wide in source, high in yield, low in obtaining cost, high in biological safety and less in side effect; and the survival rate can be obviously improved under the condition of high radiation dose, and the intestinal tissues are protected.

The invention discloses a surface-modified bacillus cereus preparation as well as a preparation method and application thereof, and relates to the technical field of viable bacteria medicines. According to the invention, dopamine and chitosan are modified on the surface of bacillus cereus to form a two-component coating bacillus cereus preparation by utilizing the spontaneous polymerization principle of dopamine and chitosan, and the two-component coating bacillus cereus preparation is used for preparing the medicine for preventing and treating enteritis. Research finds that the bacillus cereus preparation with the polydopamine and chitosan double-component coating can efficiently remove active oxygen to relieve enteritis. The preparation can remain in intestinal tracts of mice for a longer time and has a remarkable curative effect on radiation enteritis caused by 12 Gy gamma ray abdominal irradiation, and compared with an original bacterial liquid group, the weight, intestinal length, histopathology, local active oxygen removal, local inflammation, mucous membrane permeability and the like of the mice given with the preparation are obviously improved in the aspects of weight, intestinal length, histopathology, local active oxygen removal, local inflammation, mucous membrane permeability and the like.

The invention relates to application of a CXCL14 recombinant protein in preparation of a medicine for preventing or treating radiation enteritis, and belongs to the technical field of biomedicine. Excessive inflammation is inhibited by regulating chemotaxis and pro-inflammatory polarization of key immune cells such as macrophages. The CXCL14 recombinant protein directly acts on intestinal epithelial cells and crypt stem cells to promote intestinal villus repair and crypt regeneration, so that the intestinal barrier is structurally recovered. The specific value of intestinal villus length / crypt depth is remarkably increased, and it is proved that the CXCL14 recombinant protein can achieve functional healing instead of symptom relieving.

The invention discloses a traditional Chinese medicine prescription for treating radiation enteritis and a preparation method and application thereof. The traditional Chinese medicine prescription is prepared from, by mass, 10-15 g of radix puerariae, 9-12 g of rhizoma coptidis, 6-15 g of radix scutellariae, 6-10 g of radix aucklandiae, 5-10 g of herba pogostemonis, 8-12 g of herba eupatorii, 20-25 g of herba taraxaci, 15-20 g of herba agrimoniae, 15-25 g of caulis sargentodoxae, 5-15 g of radix sanguisorbae, 6-10 g of flos sophorae, 5-10 g of charred pollen typhae and 10-20 g of rhizoma alismatis. The invention solves the problem of lack of long-term effective treatment means for radiation enteritis with small side effect in the prior art, and provides a traditional Chinese medicine alternative scheme for radiation enteritis, which is safe and effective, can be used for local targeted treatment and has the advantages of simple preparation and low cost.

The invention relates to application of bacillus cereus in preparation of a medicine for intervening radiation colitis after radiotherapy, and belongs to the technical field of microorganisms. Compared with the prior art, the invention provides the application of the bacillus cereus in preparation of the medicine for intervening radiation colitis after radiotherapy, and multiple biological functions of the bacillus cereus, including repairing intestinal epithelial barrier, regulating and controlling the homeostasis of intestinal flora and inhibiting excessive immune response, are utilized directionally; therefore, source intervention on the pathological process of radiation enteritis is realized. According to the scheme, the occurrence rate of intestinal complications of radiotherapy patients is expected to be remarkably reduced, sufficient implementation of radiotherapy is ensured, meanwhile, the risks of secondary infection, metabolic disorder and the like caused by traditional medicines are avoided, and the blank of clinical treatment strategies is filled.

According to the xanthoxylin WGX-50-containing medicine for treating radiation enteritis and the application of the xanthoxylin WGX-50-containing medicine, the direct killing effect of rays on intestinal mucosa can be effectively prevented, the level of cell apoptosis and necrosis can be reduced, and intestinal mucosa ulcer shedding and inflammation infiltration after radiotherapy can be remarkably relieved, so that the toxic and side symptoms of radiotherapy are effectively relieved, and the treatment effect of radiation enteritis is improved. The production of active oxygen and inflammatory factors in the intestinal tract can be effectively reduced, and the damage of oxidative stress to the structure and function of the intestinal tract tissue is prevented, so that dual-mechanism support is provided for protecting the intestinal tract from radiation injury.

The invention discloses an application of CCDC71L in diagnosis and treatment of radiation enteritis, and provides an application of a reagent for detecting the expression level of the CCDC71L in preparation of a product for diagnosing radiation enteritis and an application of an inhibitor of the CCDC71L in preparation of a medicine for treating radiation enteritis. The invention further provides a method for screening candidate drugs for treating or preventing radiation enteritis and a method for inhibiting the expression level of inflammatory factors in macrophages. Experiments prove that the CCDC71L can realize diagnosis of radiation enteritis, and discovers that inhibition of the CCDC71L can inhibit infiltration and polarization of macrophages so as to inhibit radiation-induced inflammatory reaction, and the CCDC71L marker provided by the invention provides a new idea for diagnosis and treatment of radiation enteritis, and has a wide application prospect.

This invention discloses a birch bark extract solubilizing formulation for the prevention and treatment of radiation enteritis and its preparation method, belonging to the field of pharmaceutical technology. The formulation includes birch bark extract, ethanol, and water. Poloxamer F68 is used as the solubilizing carrier, and the mass ratio of birch bark extract to poloxamer F68 is 1:(5-15). The solubilizing formulation is prepared through steps of ethanol co-dissolution, ultrasonic treatment, rotary evaporation to remove alcohol, and resolubilization with water. This invention effectively solves the technical bottlenecks of poor water solubility, insufficient dispersibility, and inadequate storage stability of birch bark extract. The prepared formulation is uniform and stable, significantly reducing the damage to the body caused by radiation enteritis, inhibiting intestinal inflammatory responses, and repairing the intestinal mucosal barrier. It can be used to prepare drugs for the prevention and treatment of radiation enteritis. Its preparation process is simple and controllable, with high pharmaceutical safety, and is suitable for industrial production.