19 results about "Radiation Enteritis" patented technology

The invention discloses a method, a system and equipment for evaluating the treatment effect of a CCDC71L inhibitor on radiation enteritis. It is found for the first time that knock-down of CCDC71L in human colorectal epithelial cells subjected to irradiation treatment can play a role in treating radioactive injury by regulating and controlling a lipid metabolism pathway and a ferroptosis pathway. On the basis, the invention provides a method, a system and equipment for evaluating the treatment effect of the CCDC71L inhibitor on the radiation enteritis for the field, so that a doctor is assisted in evaluating the treatment effect of a patient suffering from the radiation enteritis, and a clinician is guided to formulate an individualized treatment scheme for the patient.

The invention discloses a radiation enteritis differential metabolite marker based on faeces metabonomics and a screening method and application of the radiation enteritis differential metabolite marker. The radiation proctitis differential metabolite marker is prepared from (R)-lipoic acid salt, (S)-malic acid, 3-mercaptolactic acid, 4-acetaminobutyric acid, 4-guanidinobutyric acid, 5-hydroxyindoleacetic acid, 5-methoxy indoleacetic acid, isocitrate, L-homocysteine and L-proline. The excrement differential metabolite is used as the radiation proctitis biomarker, has important significance on clinical early diagnosis of radiation proctitis, and can be used for preparing a diagnosis tool for radiation proctitis, predicting the individual treatment effect of radiation proctitis patients and preparing a medicine for treating radiation proctitis.

The application relates to application of iron-nitrogen doped graphene in preparation of anti-radioactive enteritis drugs and belongs to the technical field of biological medicines. ZIF-8 powder, 1,10-phenanthroline powder, iron (II) acetate powder and a grinding medium are placed in a closed container to perform mechanical ball milling treatment to obtain a mixed powder; under the protection of inert gas, the mixed powder is placed in a preheated tube furnace to perform pyrolysis treatment, and is cooled to room temperature to obtain iron-nitrogen doped graphene. The iron-nitrogen doped graphene has NADH oxidase-like activity, can directly catalyze the conversion of NADH into NAD + , can rapidly supplement NAD + depletion caused by radiation, can enhance PARP-dependent DNA damage repair, can reduce the generation of active oxygen (ROS), can reduce intestinal cell death and can protect the integrity of intestinal structure, and can realize efficient protection of radioactive enteritis. Moreover, the problem of low-efficiency biosynthesis of NAD + supplementation in existing radioactive intestinal injury protection technologies is solved.

The invention discloses an enemator for radiation enteritis caused by rectal cancer radiotherapy, and relates to the technical field of medical instruments, the enemator comprises a liquid storage barrel and an enema mechanism, the enema mechanism comprises a handheld sleeve, an enema intubation tube is arranged in the handheld sleeve, an enema nozzle is fixedly arranged at one end of the enema intubation tube, and the other end of the enema intubation tube is provided with an enema nozzle; and a silica gel head is fixedly arranged at the front end of the enema spray head. By arranging the enema mechanism, when a patient suffering from radiation enteritis is subjected to enema, a medical worker can use a handheld sleeve to insert an enema nozzle at the front end of an enema cannula into the anus of the patient, and meanwhile, the enema cannula is driven by a micro motor to slowly move towards the interior of the anus; meanwhile, an inflator pump can be utilized to pressurize and inflate the interior of the oil liquid box, then lubricating oil in the oil liquid box is input into the silica gel head through a rubber oil guide pipe, the automatic lubricating effect is achieved, the silica gel head is smooth in the process of entering the anus, and the comfort level of a patient can be improved.

The invention discloses bigeminal probiotic resistant dextrin / xanthan gum gel and application thereof in prevention and treatment of ionizing radiation damage. The bigeminy probiotics comprise lactobacillus reuteri and bacillus coagulans. When the two prebiotics xanthan gum and the resistant dextrin are combined to form the gel, the probiotics can be well loaded, the probiotics are protected from being damaged by gastric acid, the probiotics can stay for a long time after reaching the intestinal tract, the effect of the probiotics in the gel can be fully played, and meanwhile, the prebiotics can also fully play the role. The bigeminal probiotic resistant dextrin / xanthan gum gel can be used for preventing and treating ionizing radiation induced hematopoietic system injury and radiation enteritis.

The invention relates to and discloses a radiation enteritis prevention method based on an AI model and image fusion, which aims at the difficulty in prediction and intervention of radiation enteritis after radiotherapy of abdominal and pelvic tumors, predicts to be incorporated into 100 radiotherapy patients through historical retrospective and prospective prediction, systematically collects multi-modal data, carries out image fusion on the multi-modal data, and carries out image fusion on the multi-modal data. Utilizing interpretable machine learning to fuse radiomics parameters, flora markers and clinical variables, constructing a radiation enteritis dynamic risk prediction model, and verifying the universality of the model through 200 historical queues; key flora / metabolic targets are further screened, a coprophilous fungi transplantation intervention scheme is designed, the regulation and control effect of coprophilous fungi is verified in 50 high-risk patients, an AI auxiliary decision-making system and a microecological preparation are finally developed, a full-chain management strategy of'image-omics prediction-targeted intervention-clinical transformation 'is formed, and an innovative solution is provided for precise prevention and control of radiotherapy complications.

The invention provides a traditional Chinese medicine enema for treating radiation enteritis, and belongs to the technical field of biological medicines. According to the technical scheme, a simplified formula and a complete formula are included, the complete formula comprises 12 components including radix scutellariae, rhizoma coptidis, the root of Chinese pulsatilla, the bark of ash, raw radix sanguisorbae, herba patriniae, vinegar-processed rhizoma corydalis, radix puerariae thomsonii, cortex phellodendri, oldenlandia diffusa, dandelion and the root of three-nerved spicebush, and according to the simplified formula, the cortex phellodendri, the oldenlandia diffusa, the dandelion and the root of three-nerved spicebush are removed on the basis of the complete formula. Compared with a complete formula, the simple formula provided by the invention has the advantages that the medicine flavor is reduced from 12 to 8, and potential medicine interaction and intestinal irritation are reduced. The Chinese pulsatilla root decoction is based on Chinese pulsatilla root decoction, the raw sanguisorba root and the patrinia herb are supplemented to enhance mucous membrane repair, the corydalis tuber relieves pain, the pachyrhizua angulatus improves diarrhea, and effective improvement of a classic formula is achieved. The traditional Chinese medicine composition has the effects of clearing heat, drying dampness, cooling blood, detoxifying, promoting qi circulation, relieving pain, raising yang and stopping diarrhea, has the effects of clearing heat, cooling blood, stopping bleeding, relieving pain and the like, and has an exact and remarkable treatment effect on radiation enteritis.

The invention provides application of cordate houttuynia extracellular vesicles in preparation of a medicine for treating radiation enteritis. As a vesicle structure containing lipid, protein, miRNA and active small molecules, the exosome disclosed by the invention has a multi-target regulation effect; the cordate houttuynia is wide in source, high in yield, low in obtaining cost, high in biological safety and less in side effect; and the survival rate can be obviously improved under the condition of high radiation dose, and the intestinal tissues are protected.

The invention discloses a surface-modified bacillus cereus preparation as well as a preparation method and application thereof, and relates to the technical field of viable bacteria medicines. According to the invention, dopamine and chitosan are modified on the surface of bacillus cereus to form a two-component coating bacillus cereus preparation by utilizing the spontaneous polymerization principle of dopamine and chitosan, and the two-component coating bacillus cereus preparation is used for preparing the medicine for preventing and treating enteritis. Research finds that the bacillus cereus preparation with the polydopamine and chitosan double-component coating can efficiently remove active oxygen to relieve enteritis. The preparation can remain in intestinal tracts of mice for a longer time and has a remarkable curative effect on radiation enteritis caused by 12 Gy gamma ray abdominal irradiation, and compared with an original bacterial liquid group, the weight, intestinal length, histopathology, local active oxygen removal, local inflammation, mucous membrane permeability and the like of the mice given with the preparation are obviously improved in the aspects of weight, intestinal length, histopathology, local active oxygen removal, local inflammation, mucous membrane permeability and the like.

The invention relates to application of a CXCL14 recombinant protein in preparation of a medicine for preventing or treating radiation enteritis, and belongs to the technical field of biomedicine. Excessive inflammation is inhibited by regulating chemotaxis and pro-inflammatory polarization of key immune cells such as macrophages. The CXCL14 recombinant protein directly acts on intestinal epithelial cells and crypt stem cells to promote intestinal villus repair and crypt regeneration, so that the intestinal barrier is structurally recovered. The specific value of intestinal villus length / crypt depth is remarkably increased, and it is proved that the CXCL14 recombinant protein can achieve functional healing instead of symptom relieving.

The invention discloses a traditional Chinese medicine prescription for treating radiation enteritis and a preparation method and application thereof. The traditional Chinese medicine prescription is prepared from, by mass, 10-15 g of radix puerariae, 9-12 g of rhizoma coptidis, 6-15 g of radix scutellariae, 6-10 g of radix aucklandiae, 5-10 g of herba pogostemonis, 8-12 g of herba eupatorii, 20-25 g of herba taraxaci, 15-20 g of herba agrimoniae, 15-25 g of caulis sargentodoxae, 5-15 g of radix sanguisorbae, 6-10 g of flos sophorae, 5-10 g of charred pollen typhae and 10-20 g of rhizoma alismatis. The invention solves the problem of lack of long-term effective treatment means for radiation enteritis with small side effect in the prior art, and provides a traditional Chinese medicine alternative scheme for radiation enteritis, which is safe and effective, can be used for local targeted treatment and has the advantages of simple preparation and low cost.

The invention relates to application of bacillus cereus in preparation of a medicine for intervening radiation colitis after radiotherapy, and belongs to the technical field of microorganisms. Compared with the prior art, the invention provides the application of the bacillus cereus in preparation of the medicine for intervening radiation colitis after radiotherapy, and multiple biological functions of the bacillus cereus, including repairing intestinal epithelial barrier, regulating and controlling the homeostasis of intestinal flora and inhibiting excessive immune response, are utilized directionally; therefore, source intervention on the pathological process of radiation enteritis is realized. According to the scheme, the occurrence rate of intestinal complications of radiotherapy patients is expected to be remarkably reduced, sufficient implementation of radiotherapy is ensured, meanwhile, the risks of secondary infection, metabolic disorder and the like caused by traditional medicines are avoided, and the blank of clinical treatment strategies is filled.

According to the xanthoxylin WGX-50-containing medicine for treating radiation enteritis and the application of the xanthoxylin WGX-50-containing medicine, the direct killing effect of rays on intestinal mucosa can be effectively prevented, the level of cell apoptosis and necrosis can be reduced, and intestinal mucosa ulcer shedding and inflammation infiltration after radiotherapy can be remarkably relieved, so that the toxic and side symptoms of radiotherapy are effectively relieved, and the treatment effect of radiation enteritis is improved. The production of active oxygen and inflammatory factors in the intestinal tract can be effectively reduced, and the damage of oxidative stress to the structure and function of the intestinal tract tissue is prevented, so that dual-mechanism support is provided for protecting the intestinal tract from radiation injury.

The invention discloses a ratio probe for precise diagnosis and treatment of radioactive intestinal injury as well as a preparation method and application thereof, relates to the technical field of nano biological materials, and solves the technical problems that in the prior art, radiation enteritis diagnosis depends on subjective symptoms and invasive examination, intestinal ROS cannot be monitored noninvasively and quantitatively, and RIE is difficult to diagnose early and evaluate dynamically. The ratio probe for accurate diagnosis and treatment of radioactive intestinal injury is prepared, and the ratio probe comprises a rare earth doped down-conversion nanoparticle core-shell structure DCNP and has near-infrared second-region NIR-II emission capability; the reactive oxygen species (ROS)-sensitive IR786s dye molecules are coated on the surface of the nanoparticle core-shell structure DCNP, and are used as a response unit of the ROS and a regulation and control unit of an absorption competition induced emission (ACIE) mechanism; a bacterial membrane EM of Escherichia coli Nissle 1917EcN is coated on the outer side of a coating of a nanoparticle core-shell structure DCNP for modifying IR786s dye, so that bionic camouflage of the nanoprobe is realized, the residence time of the nanoprobe in an intestinal tract is prolonged, and the targeting property of the nanoprobe to a diseased region is improved.

The invention discloses a traditional Chinese medicine decoction for treating radiation enteritis and a preparation method thereof, and belongs to the technical field of medical health, the traditional Chinese medicine decoction for treating radiation enteritis comprises the following raw materials by weight: 6-12 parts of Chinese pulsatilla root, 6-12 parts of phellodendron, 6-12 parts of ash bark, 6-9 parts of coptis, 6-12 parts of white peony root, 6-12 parts of Chinese angelica, 6-9 parts of betel nut, 3-6 parts of elecampane, 3-6 parts of licorice, 3-6 parts of rheum officinale, 6-12 parts of scutellaria baicalensis, and 3-6 parts of cinnamon. The traditional Chinese medicine decoction formula for treating radiation enteritis takes the root of Chinese pulsatilla, coptis chinensis, cortex phellodendri and cortex fraxini as cores, and has the effects of clearing heat, drying dampness, detoxifying and stopping dysentery; chinese angelica and white paeony root are used for regulating qi and blood and relieving spasm and pain; radix aucklandiae and betel nut promote qi circulation, remove stagnation and relieve abdominal distension; the rhubarb has the effects of relaxing bowels, purging heat and promoting intestinal toxin discharge; cinnamon has the effects of warming spleen and stomach for dispelling cold and balancing cold drug properties; the traditional Chinese medicine decoction disclosed by the invention is reasonable in composition, small in dosage, green, environment-friendly, simple to operate, remarkable in curative effect and small in side effect.

The invention relates to the field of medicines, and particularly provides a compound sophora flavescens extract and application thereof in preparation of medicines for preventing or treating radioactive intestinal injury. The compound sophora flavescens extract effectively improves radiation enteritis and symptoms such as diarrhea and hematochezia caused by radiation enteritis, and provides a medicine choice for treatment of radiation enteritis.

The invention discloses an application of methyl mercaptan oxidase Selenbp1 in preparation of a medicine for treating radiation colitis and proctitis. The research finds that the expression of Selenbp1 in a clinical specimen of radiation enteritis is obviously reduced; animal experiments and organoid culture experiments show that after the Selenbp1 is knocked out, intestinal epithelium is repaired to be impaired; in-vitro experiments find that the lack of Selenbp1 can cause the intestinal epithelium to generate a proinflammatory factor TNF-a and promote the polarization of macrophage M1; on a molecular mechanism, after the Selenbp1 enters a cell nucleus, SUMO modification of an intestinal epithelium key molecule Satb2 is promoted, and intestinal epithelium repair is facilitated. After the expression of the methyl mercaptan oxidase Selenbp1 is increased, the histological damage of radiation colitis can be alleviated. Therefore, the methyl mercaptan oxidase Selenbp1 can be used for preparing the medicine for treating radiation colitis and proctitis.

The invention discloses an application of CCDC71L in diagnosis and treatment of radiation enteritis, and provides an application of a reagent for detecting the expression level of the CCDC71L in preparation of a product for diagnosing radiation enteritis and an application of an inhibitor of the CCDC71L in preparation of a medicine for treating radiation enteritis. The invention further provides a method for screening candidate drugs for treating or preventing radiation enteritis and a method for inhibiting the expression level of inflammatory factors in macrophages. Experiments prove that the CCDC71L can realize diagnosis of radiation enteritis, and discovers that inhibition of the CCDC71L can inhibit infiltration and polarization of macrophages so as to inhibit radiation-induced inflammatory reaction, and the CCDC71L marker provided by the invention provides a new idea for diagnosis and treatment of radiation enteritis, and has a wide application prospect.

This invention discloses a birch bark extract solubilizing formulation for the prevention and treatment of radiation enteritis and its preparation method, belonging to the field of pharmaceutical technology. The formulation includes birch bark extract, ethanol, and water. Poloxamer F68 is used as the solubilizing carrier, and the mass ratio of birch bark extract to poloxamer F68 is 1:(5-15). The solubilizing formulation is prepared through steps of ethanol co-dissolution, ultrasonic treatment, rotary evaporation to remove alcohol, and resolubilization with water. This invention effectively solves the technical bottlenecks of poor water solubility, insufficient dispersibility, and inadequate storage stability of birch bark extract. The prepared formulation is uniform and stable, significantly reducing the damage to the body caused by radiation enteritis, inhibiting intestinal inflammatory responses, and repairing the intestinal mucosal barrier. It can be used to prepare drugs for the prevention and treatment of radiation enteritis. Its preparation process is simple and controllable, with high pharmaceutical safety, and is suitable for industrial production.