Traditional Chinese medicine decoction for treating radiation enteritis and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine decoction for treating radiation enteritis and a preparation method thereof, and belongs to the technical field of medical health, the traditional Chinese medicine decoction for treating radiation enteritis comprises the following raw materials by weight: 6-12 parts of Chinese pulsatilla root, 6-12 parts of phellodendron, 6-12 parts of ash bark, 6-9 parts of coptis, 6-12 parts of white peony root, 6-12 parts of Chinese angelica, 6-9 parts of betel nut, 3-6 parts of elecampane, 3-6 parts of licorice, 3-6 parts of rheum officinale, 6-12 parts of scutellaria baicalensis, and 3-6 parts of cinnamon. The traditional Chinese medicine decoction formula for treating radiation enteritis takes the root of Chinese pulsatilla, coptis chinensis, cortex phellodendri and cortex fraxini as cores, and has the effects of clearing heat, drying dampness, detoxifying and stopping dysentery; chinese angelica and white paeony root are used for regulating qi and blood and relieving spasm and pain; radix aucklandiae and betel nut promote qi circulation, remove stagnation and relieve abdominal distension; the rhubarb has the effects of relaxing bowels, purging heat and promoting intestinal toxin discharge; cinnamon has the effects of warming spleen and stomach for dispelling cold and balancing cold drug properties; the traditional Chinese medicine decoction disclosed by the invention is reasonable in composition, small in dosage, green, environment-friendly, simple to operate, remarkable in curative effect and small in side effect.

Description

[0001] A traditional Chinese medicine decoction for treating radiation enteritis and its preparation method Technical Field

[0002] The present invention belongs to the technical field of medical and health, and particularly relates to a traditional Chinese medicine decoction for treating radiation enteritis and its preparation method. Background Art

[0003] With the progress of modern medicine, radiotherapy plays an increasingly important role in cancer treatment. However, at the same time, radiation enteritis, a common side effect of radiotherapy, brings great pain to patients. Radiation enteritis can cause symptoms such as diarrhea, abdominal pain, and absorption dysfunction, seriously affecting the quality of life of patients. Currently, clinically, anti-inflammatory, analgesic, and symptomatic treatment methods are mostly used to relieve symptoms, but the curative effect is limited, and drug treatment is often accompanied by certain side effects. Therefore, finding a method with less side effects and more significant treatment effects has become the focus of current research.

[0004] In this context, traditional Chinese medicine has attracted wide attention from scientific research personnel with its unique overall treatment concept and advantages in dealing with complex diseases. Especially for radiation enteritis, traditional Chinese medicine is considered a potential effective treatment method due to its mildness and relatively small side effects. Research shows that some specific traditional Chinese medicine components have anti-inflammatory, antioxidant, and intestinal mucosa repair effects, which make traditional Chinese medicine a potential option for treating radiation enteritis. However, existing traditional Chinese medicine treatment programs are mostly single herbs or proprietary Chinese medicine preparations, and their curative effects and safety need to be further verified, and there are uncertain factors in aspects such as dosage and decocting methods.

[0005] Therefore, in view of the above technical problems, it is necessary to provide a traditional Chinese medicine decoction for treating radiation enteritis and its preparation method.

[0006] The information disclosed in this background art section is only intended to enhance the overall understanding of the present invention and should not be regarded as an admission or any form of suggestion that this information constitutes prior art already known to those of ordinary skill in the art. Summary of the Invention

[0007] The purpose of the present invention is to provide a traditional Chinese medicine decoction for treating radiation enteritis and its preparation method, which can solve the above technical problems.

[0008] To achieve the above purpose, the technical solution provided by a specific embodiment of the present invention is as follows: A traditional Chinese medicine decoction for treating radiation enteritis is composed of the following raw materials in parts by weight: 6-12 parts of Pulsatilla chinensis, 6-12 parts of Phellodendron amurense, 6-12 parts of Cortex Fraxini, 6-9 parts of Coptis chinensis, 6-12 parts of Paeonia lactiflora, 6-12 parts of Angelica sinensis, 6-9 parts of Areca catechu, 3-6 parts of Aucklandia lappa, 3-6 parts of Glycyrrhiza uralensis, 3-6 parts of Rheum palmatum, 6-12 parts of Scutellaria baicalensis, and 3-6 parts of Cinnamomum cassia.

[0009] In one or more embodiments of the present invention, the parts by weight of each raw material are as follows: 9-12 parts of Pulsatilla chinensis, 9-12 parts of Phellodendron amurense, 9-12 parts of Cortex Fraxini, 7-9 parts of Coptis chinensis, 9-12 parts of Paeonia lactiflora, 9-12 parts of Angelica sinensis, 7-9 parts of Areca catechu, 4-6 parts of Aucklandia lappa, 4-6 parts of Glycyrrhiza uralensis, 4-6 parts of Rheum palmatum, 9-12 parts of Scutellaria baicalensis, and 4-6 parts of Cinnamomum cassia.

[0010] In one or more embodiments of the present invention, the parts by weight of the raw materials are further preferably: 6 parts of Coptis chinensis, 3 parts of Aucklandia lappa, 3 parts of Glycyrrhiza uralensis, 3 parts of Rheum palmatum, 3 parts of Cinnamomum cassia, and the remaining raw materials are all 6 parts.

[0011] In one or more embodiments of the present invention, the dosage form of the traditional Chinese medicine decoction is oral liquid, granule or concentrated pill.

[0012] In one or more embodiments of the present invention, a method for preparing a traditional Chinese medicine decoction for treating radiation enteritis is characterized by comprising the following steps: S1. Weigh the raw material slices according to the ratio, soak them in 800 ml of drinking water until the cores of the slices are moist, and the soaking time is 50-70 minutes; S2. Place the soaked raw materials in a casserole, bring to a boil over high heat, then switch to low heat and continue to boil for 50-70 minutes, and filter to obtain 400 ml of medicinal liquid.

[0013] In one or more embodiments of the present invention, the soaking time in S1 is 60 minutes, and the low-heat boiling time in S2 is 60 minutes.

[0014] In one or more embodiments of the present invention, the temperature of the low-heat boiling in S2 is 90-95 °C.

[0015] In one or more embodiments of the present invention, after the boiling in S2 is completed, the medicinal liquid is divided into two portions, each portion being 200 ml.

[0016] In one or more embodiments of the present invention, the casserole is made of ceramic or purple sand.

[0017] In one or more embodiments of the present invention, it further includes refrigerating the medicinal liquid in an environment of 4-8 °C, and the storage time does not exceed 48 hours.

[0018] Compared with the prior art, the traditional Chinese medicine decoction for treating radiation enteritis of the present invention has a reasonable composition, requires less medication, is green and environmentally friendly, is simple to operate, has remarkable curative effects, and has few side effects. Among them, the prescription takes Pulsatilla chinensis, Coptis chinensis, Phellodendron amurense, and Cortex Fraxini as the core to exert the effects of clearing heat and drying dampness, detoxifying and stopping dysentery; supplemented by Angelica sinensis and Paeonia lactiflora to regulate qi and blood, relieve spasm and pain; Aucklandia lappa and Areca catechu to promote qi movement and relieve stagnation, and relieve abdominal distension; Rheum palmatum to purge heat and promote defecation, and promote the excretion of intestinal toxins; Cinnamomum cassia to warm the middle-jiao and dispel cold, and balance the cold nature of the medicine. Each component acts synergistically, targeting the pathogenesis of "dampness-heat stasis-toxin" of radiation enteritis, and significantly improving symptoms such as abdominal pain, diarrhea, and hematochezia. By compatibility with warm-middle-jiao and spleen-strengthening herbs such as Cinnamomum cassia and Glycyrrhiza uralensis, it neutralizes the irritation of bitter-cold herbs such as Coptis chinensis and Rheum palmatum to the gastrointestinal tract, and avoids the defect of traditional heat-clearing prescriptions that are prone to spleen-stomach deficiency-cold, especially suitable for the long-term weak constitution of patients with radiation enteritis. The dosage ranges of each medicinal material in the prescription are clear (such as 6-9 parts of Coptis chinensis, 3-6 parts of Rheum palmatum), and the ratio can be adjusted according to the patient's constitution (such as excessive heat-toxin or qi-blood weakness) to achieve individualized treatment. The basic decoction can be taken directly, or can be further made into granules, oral liquids or concentrated pills to meet the needs of different patients (such as using the decoction for rapid onset in the acute stage and pills for easy carrying in the remission stage). The medicinal materials in the prescription are all common traditional Chinese medicines, with easily available raw materials and low prices. The preparation process does not require complex equipment and is suitable for preparation in grass-roots medical institutions and families. The preparation method of the traditional Chinese medicine decoction for treating radiation enteritis of the present invention adopts the process of "soaking until the inner core is moist → decocting with strong fire first and then slow fire", which ensures the full dissolution of the effective components of the medicinal slices (such as coptisine alkaloids, baicalin, angelica polysaccharides, etc.), and at the same time avoids the loss of volatile components (such as volatile oil of Aucklandia lappa) caused by high-temperature and long-time decoction. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for the description of the embodiments or the prior art. Obviously, the drawings in the following description are only some embodiments recorded in the present invention. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.

[0020] Figure 1 It is a flowchart of the preparation method of a traditional Chinese medicine decoction for treating radiation enteritis in an embodiment of the present invention. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0021] To enable those skilled in the art to better understand the technical solutions in the present invention, the following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0022] Example 1 (Basic Formulation and Preparation) Raw material ratio (unit: gram): Pulsatilla chinensis 9, Phellodendron amurense 9, Cortex Fraxini 9, Coptis chinensis 6, Paeonia lactiflora 9, Angelica sinensis 9, Areca catechu 6, Aucklandia lappa 4, Glycyrrhiza uralensis 4, Rheum officinale 4, Scutellaria baicalensis 9, Cinnamomum cassia 4.

[0023] Preparation method: S1. Weigh the above-mentioned raw material slices, add 800 ml of drinking water and soak for 60 minutes until the inner core of the slices is moistened; S2. Place the soaked raw materials in a ceramic casserole, bring to a boil over high heat, then turn to low heat (temperature controlled at 90 - 95 °C) and decoct for 60 minutes, filter to remove the residue, and obtain 400 ml of medicinal liquid; S3. Divide the medicinal liquid into two portions, each portion being 200 ml, store it refrigerated at 4 °C, and consume it within 48 hours. Administration method: Take 200 ml each in the morning and evening, and those with relatively weak gastrointestinal function take it warm 1 hour after meals.

[0024] Example 2 (High-dose Formulation) Raw material ratio (unit: gram): Pulsatilla chinensis 12, Phellodendron amurense 12, Cortex Fraxini 12, Coptis chinensis 9, Paeonia lactiflora 12, Angelica sinensis 12, Areca catechu 9, Aucklandia lappa 6, Glycyrrhiza uralensis 6, Rheum officinale 6, Scutellaria baicalensis 12, Cinnamomum cassia 6.

[0025] Preparation method: Same as Example 1, and the low-heat decocting time is extended to 70 minutes.

[0026] Example 3 (Low-dose Formulation) Raw material ratio (unit: gram): Pulsatilla chinensis 6, Phellodendron amurense 6, Cortex Fraxini 6, Coptis chinensis 6, Paeonia lactiflora 6, Angelica sinensis 6, Areca catechu 6, Aucklandia lappa 3, Glycyrrhiza uralensis 3, Rheum officinale 3, Scutellaria baicalensis 6, Cinnamomum cassia 3.

[0027] Preparation method: Same as Example 1, and the low-heat decocting time is shortened to 50 minutes.

[0028] The traditional Chinese medicine decoction formula for treating radiation enteritis of the present invention takes Pulsatilla chinensis, Coptis chinensis, Phellodendron amurense, and Cortex Fraxini as the core, exerting the effects of clearing heat and drying dampness, detoxifying and stopping dysentery; supplemented by Angelica sinensis and Paeonia lactiflora to regulate qi and blood, relieve spasm and pain; Aucklandia lappa and Areca catechu to promote qi flow and relieve stagnation, and relieve abdominal distension; Rheum palmatum to purge heat and promote defecation, and promote the discharge of intestinal toxins; Cinnamomum cassia to warm the middle-jiao and dispel cold, and balance the cold nature of the medicine. The various components act synergistically, targeting the pathogenesis of "damp-heat stasis-toxin" of radiation enteritis, and significantly improving symptoms such as abdominal pain, diarrhea, and bloody stools.

[0029] By combining warm-nourishing and spleen-strengthening herbs such as Cinnamomum cassia and Glycyrrhiza uralensis, it neutralizes the irritation of bitter-cold herbs such as Coptis chinensis and Rheum palmatum to the gastrointestinal tract, avoiding the defect of traditional heat-clearing prescriptions that are prone to spleen and stomach deficiency-cold, and is especially suitable for the long-term weak constitution of radiation enteritis patients.

[0030] The dosage ranges of each medicinal material in the formula are clear (such as 6-9 parts of Coptis chinensis, 3-6 parts of Rheum palmatum), and the ratio can be adjusted according to the patient's constitution (such as excessive heat-toxin or qi and blood deficiency) to achieve individualized treatment.

[0031] The basic decoction can be taken directly, or can be further made into granules, oral liquids or concentrated pills to meet the needs of different patients (such as using the decoction for rapid onset in the acute stage and pills for easy carrying in the remission stage).

[0032] The medicinal materials in the formula are all common traditional Chinese medicines, with easily available raw materials and low prices. The preparation process does not require complex equipment and is suitable for grass-roots medical institutions and families to prepare.

[0033] The preparation method of the traditional Chinese medicine decoction for treating radiation enteritis of the present invention adopts the process of "soaking until the inner core is moist → decocting with strong fire first and then slow fire", ensuring the full dissolution of the effective components of the cut pieces (such as coptisine alkaloids, baicalin, angelica polysaccharides, etc.), and at the same time avoiding the loss of volatile components (such as Aucklandia lappa volatile oil) caused by high-temperature long-term decoction.

[0034] For those skilled in the art, it is obvious that the present invention is not limited to the details of the above exemplary embodiments, and can be implemented in other specific forms without departing from the spirit or basic characteristics of the present invention. Therefore, from any point of view, the embodiments should be regarded as exemplary and non-limiting. The scope of the present invention is defined by the appended claims rather than the above description. Therefore, all changes falling within the meaning and scope of the equivalent elements of the claims are intended to be included in the present invention. Any reference signs in the claims should not be regarded as limiting the claimed rights.

[0035] In addition, it should be understood that although this specification is described according to embodiments, not every embodiment only contains an independent technical solution. This narrative way of the specification is only for clarity. Those skilled in the art should regard the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A Chinese medicinal decoction for treating radiation enteritis, characterized in that: The invention is composed of the following raw materials in parts by weight: 6-12 parts of Pulsatilla striata, 6-12 parts of Phellodendron chinense, 6-12 parts of Qinpi, 6-9 parts of Coptis chinensis, 6-12 parts of White Peony Root, 6-12 parts of Angelica sinensis, 6-9 parts of Areca Nut, 3-6 parts of Aucklandia lappa, 3-6 parts of Licorice, 3-6 parts of Rhubarb, 6-12 parts of Scutellaria baicalensis and 3-6 parts of Cinnamon Bark.

2. A Chinese medicinal decoction for treating radiation enteritis according to claim 1, characterized in that: The weight parts of each raw material are: 9-12 parts of Pulsatillae Scutellariae, 9-12 parts of Phellodendron Amurense, 9-12 parts of Qinpi, 7-9 parts of Coptis chinensis, 9-12 parts of White Peony Root, 9-12 parts of Angelica Sinensis, 7-9 parts of Areca Nut, 4-6 parts of Aucklandia Sinensis, 4-6 parts of Licorice, 4-6 parts of Rhubarb, 9-12 parts of Scutellariae Baicalensis, and 4-6 parts of Cinnamon Bark.

3. A Chinese medicinal decoction for treating radiation enteritis according to claim 1, characterized in that: The weight proportion of the raw materials is further preferably: 6 parts of coptis root, 3 parts of costusroot, 3 parts of liquorice, 3 parts of rhubarb, 3 parts of cinnamon, and 6 parts of the other raw materials.

4. A Chinese medicinal decoction for treating radiation enteritis according to claim 1, characterized in that: The dosage form of the Chinese medicine decoction is oral liquid, granules or concentrated pills.

5. A method for preparing a Chinese medicinal decoction for treating radiation enteritis according to any one of claims 1 to 4, characterized in that: The following steps are involved: S1. Weigh the raw material slices according to the proportion, soak them in 800 ml of drinking water until the inner core of the slices is moistened, and the soaking time is 50 to 70 minutes; S2. Place the soaked raw materials in a casserole, boil over high heat until boiling, then continue boiling over low heat for 50 to 70 minutes, and filter to obtain 400 ml of medicinal liquid.

6. The method according to claim 5, characterized in that: The soaking time in S1 is 60 minutes, and the medium-heat decocting time in S2 is 60 minutes.

7. The manufacturing method according to claim 5, characterized in that: The temperature of the medium heat decocting in S2 is 90-95°C.

8. The manufacturing method according to claim 5, characterized in that: After the decoction in S2 is completed, the medicinal liquid is divided into two portions, each with 200 ml.

9. The manufacturing method according to claim 5, characterized in that: The clay pot is made of ceramic or purple sand.

10. The manufacturing method according to claim 5, characterized in that: It also includes refrigerating the drug solution at 4 to 8°C for no more than 48 hours.

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