380 results about "Cell function" patented technology

A multi-layered microcapsule has an inner extracellular matrix and an outer shell. The inner extracellular matrix includes a first inner layer of biopolymer and a second intermediate layer of polymer that provides partial immune-protection and holds the first layer in place. The outer shell can form an exoskeleton to provide mechanical stability. Each of the individual layers can be varied to optimize mechanical stability, cell function, and immuno-protection.

Methods for modulating (inhibiting or stimulating) retinoid-related orphan receptor γ (RORγ) activity. This modulation has numerous effects, including inhibition of T_H-17 cell function and/or T_H-17 cell activity, and inhibition of re-stimulation of T_H-17 cells, which are beneficial to treatment of inflammation and autoimmune disorders. Stimulation of RORγ results in stimulation of T_H-17 cell function and/or activity which is beneficial for immune-enhancing compositions (e.g., vaccines).

Provided herein are methods of culturing cells in vitro in order to exploit the biochemical production ability of the cells to make metabolites that are evaluated and harvested for their biological effects. Also provided are systems for evaluating extracts from such cultured cells to characterize their biological activity(s), particularly with regard to impact on health, wellbeing, longevity, DNA maintenance, mitochondrial health and/or biogenesis, and so forth. Biologically active extracts, components thereof, and compositions (such as cosmetic or pharmaceutical preparations) made comprising such, are also provided.

A synapse for a spike timing dependent (STDP) function cell includes a memory device having a variable resistance, such as a memristor, and a transistor connected to the memory device. A channel of the memory device is connected in series with a channel of the transistor.

A catalytic converter having an excellent purification efficiency and small pressure loss and a method for producing the same is provided. A catalytic converter comprises a catalyst coating layer which is coated on the surface of the partition walls of the honeycomb structural body having partition walls which divide and form a plurality of cells functioning as fluid passages. 10% or more of the plurality of the cells are plugged by the plug portions which are formed at the one end or the middle of the passage, the average maximum distance of image of the honeycomb structural body is 10 μm or more and the porosity of the honeycomb structural body is 40% or more, the catalyst coating layer contains at least one oxide selected from the group consisting of alumina, ceria, titania, silica and zirconia, and also a catalyst containing at least one precious metal selected from the group consisting of platinum, rhodium and palladium, or metal exchanged zeolite or vanadium is supported in the catalyst coating layer as the catalytic active constituent, the average maximum distance of image of the catalyst coating layer is 10 μm or more, and the porosity of the catalyst coating layer is 40% or more.

The present invention provides a molten sodium secondary cell. In some cases, the secondary cell includes a sodium metal negative electrode, a positive electrode compartment that includes a positive electrode disposed in a liquid positive electrode solution, and a sodium ion conductive electrolyte membrane that separates the negative electrode from the positive electrode solution. In such cases, the electrolyte membrane can comprise any suitable material, including, without limitation, a NaSICON-type membrane. Furthermore, in such cases, the liquid positive electrode solution can comprise any suitable positive electrode solution, including, but not limited to, an aqueous sodium hydroxide solution. Generally, when the cell functions, the sodium negative electrode is molten and in contact with the electrolyte membrane. Additionally, the cell is functional at an operating temperature between about 100° C. and about 170° C. Indeed, in some instances, the molten sodium secondary cell is functional between about 110° C. and about 130° C.

The invention provides a method for preparing cartilage with a high mechanical property based on 3D bioprinting. The method comprises the following steps: preparing silk fibers, preparing a gelatin solution, preparing ciological ink containing cells, carrying out 3D cartilage printing, performing cell culture and differentiation on a printed tissue to form the cartilage. The method solves the problems of polarization of 2-dimension culture for cells and high body and surface ratio of cells through the 3D bioprinting technology; sodium alginate and calcium ions form ionic bonds, and gelatin and methacrylic anhydride form covalent bonds, so that the 3D bioprinted cartilage is good in mechanical property and is not easily broken; the gelatin has biocompatibility and degradability of normal biological material hydrogel, has bioactivity, and is good for cell growth and differentiation and realization of cell functions.

The present invention relates to compositions and methods for altering cell function. In particular, the present invention provides compositions comprising selenium (e.g., SEL-PLEX) and methods of using the same (e.g., as a therapeutic and/or prophylactic treatment for neurodegenerative disease). Additionally, the present invention demonstrates that specific forms of selenium (e.g., SEL-PLEX) possess the ability to alter expression of genes associated with disease and/or aging while other forms of selenium (e.g., selenomethionine) do not.

This invention focuses on the marriage of solid-state electronics and neuronal function to create a new high-throughput electrophysiological assay to determine a compound's acute and chronic effect on cellular function. Electronics, surface chemistry, biotechnology, and fundamental neuroscience are integrated to provide an assay where the reporter element is an array of electrically active cells. This innovative technology can be applied to neurotoxicity, and to screening compounds from combinatorial chemistry, gene function analysis, and basic neuroscience applications. The system of the invention analyzes how the action potential is interrupted by drugs or toxins. Differences in the action potentials are due to individual toxins acting on different biochemical pathways, which in turn affects different ion channels, thereby changing the peak shape of the action potential differently for each toxin. Algorithms to analyze the action potential peak shape differences are used to indicate the pathway(s) affected by the presence of a new drug or compound; from that, aspects of its function in that cell are deduced. This observation can be exploited to determine the functional category of biochemical action of an unknown compound. An important aspect of the invention is surface chemistry that permits establishment of a high impedance seal between cell and a metal microelectrode. This seal recreates the interface that enables functional patch-clamp electrophysiology with glass micropipettes, and allows extracellular electrophysiology on a microelectrode array. Thus, the invention teaches the feasibility of using living cells as diagnostics for high throughput real-time assays of cell function.

A honeycomb structure includes: a porous substrate having porous partition walls separating and forming a plurality of cells functioning as fluid passages, a porous coat layer disposed on a surface of the partition walls to inhibit microparticles from entering, a surface of the coat layer having an uneven shape to increase a surface area, and plugging portions for plugging cells so that a fluid flowing into the structure from an opening portions on one end side of predetermined cells may pass through the partition walls and flows out from opening portions on the other side of the other cells to allow the gas to flow through the partition walls and the coat layers. The honeycomb structure can inhibit the pressure loss from increasing upon trapping particulate matter in exhaust gas and can effectively combust and remove the trapped particulate matter.

An electrochemical cell having a cation-conductive ceramic membrane and an acidic anolyte. Generally, the cell includes a catholyte compartment and an anolyte compartment that are separated by a cation-conductive membrane. While the catholyte compartment houses a primary cathode, the anolyte compartment houses an anode and a secondary cathode. In some cases, a current is passed through the electrodes to cause the secondary cathode to evolve hydrogen gas. In other cases, a current is passed between the electrodes to cause the secondary cathode to evolve hydroxyl ions and hydrogen gas. In still other cases, hydrogen peroxide is channeled between the secondary cathode and the membrane to form hydroxyl ions. In yet other cases, the cell includes a diffusion membrane disposed between the secondary cathode and the anode. In each of the aforementioned cases, the cell functions to maintain the pH of a fluid contacting the membrane at an acceptably high level.

The present invention relates to a method for the production and the selection of human or chimaeric or humanized antibodies or molecules that comprise the Fc region of human IgG, capable of modulating the activity of one or several particular Fc receptors, such as the triggering of inhibitory functions through the human type IIB receptors of IgG (FcgammaRIIB/CD32).

The invention discloses a multi-connecting-rod controllable mining mechanism with a variable cell function. The multi-connecting-rod controllable mining mechanism is characterized in that one end of a big arm is connected on a frame while the other end of the same is connected with a first connecting rod through a second rotating pair, the other end of the first connecting rod is connected with a second connecting rod, and the other end of the second connecting rod is connected with the middle of a fourth connecting rod; one end of a first driving member is connected to the frame while the other end of the same is connected with a bucket rod, and the other end of the bucket rod is connected with a bucket; the middle of the bucket rod is connected with the middle of the second connecting rod; one end of a second driving member is connected to the frame while the other end of the same is connected with a third connecting rod, the other end of the third connecting rod is connected with the fourth connecting rod through a tenth rotating pair, and the fourth connecting rod is connected to the bucket; a first electromagnetic locking device and a second electromagnetic locking device are respectively mounted on the second rotating pair and the tenth rotating pair and used for performing timely locking on a mining machine under different working conditions. The hydraulic mining machine is flexible, and manufacturing cost of the mining machine is lowered.

Methods for treating impaired glucose tolerance and early and late stage diabetes in mammals, for prophylactically sparing β-cell function, aiding in preventing β-cell death, preventing the onset of overt diabetes in a mammal with type 2 diabetes, treating the current level of glycemic control dysfunction of a mammal with impaired glucose tolerance or diabetes, comprising orally administering insulin and a delivery agent that facilitates insulin absorption from the gastrointestinal tract at the time of or shortly before mealtime, e.g., within about 10 minutes prior to ingestion of a meal, on a chronic basis. The methods also comprise, in addition to administering a rapid-acting insulin to provide a first insulin peak, administering a slow acting insulin to provide a second insulin peak occurring at a later time but of a longer duration. These methods achieve improved glycemic control without the risks of hypoglycemia, hyperinsulinemia and weight gain and the need for frequent blood glucose monitoring that are normally associated with insulin therapy.

Multi-cell battery packs can be made safer with certain features that mitigate the consequences of cell failure. Parameters of a cell are monitored to determine when the cell should be disconnected from the pack in case of a fault. The battery is reconfigured to continue operating in a safer mode. An over-charging prevention system reduces the maximum voltage that remaining battery pack can be charged to, so that the cells do not overcharge. Additional circuitry allows the disconnected cell to be periodically reconnected to the battery pack to determine if its conditions have sufficiently improved. The cells also include components for self-powering these cell functions while it is disconnected from the rest of the circuit.

The invention relates to the field of medicinal chemistry, and discloses three crystal forms of cabazitaxel, i.e., an ester compound crystal form J of cabazitaxel, a hydrate crystal form G of cabazitaxel and a cabazitaxel crystal form I, and a preparation method of a novel crystal form of cabazitaxel. The novel cabazitaxel form has superior performance on the aspects of oral absorptivity, activation of metabolism and suppression of mitosis and interval cell function of cells, is weak in toxicity, has high storing and treating stability, and can be applied to preparation of a medicament for treating prostatitis.

A biocompatible material, wherein at least a part of a surface of the biocompatible material is characterized by a micro or nano-meter scale topographical structure comprising a plurality of features where the structure is selected to promote a predetermined cell function in vivo or ex vivo in cell or tissue culture.

A totally-integrated high-flux cell level micro-fluidic chip medicine evaluating system is a multifunctional cell level medicine evaluating system treating a micro-fluidic chip as a core technology, starting from the total design of an integrated high-flux automatic micro-fluidic chip system and integrating a cell function chip module, a flow path control module, a cell culture microenvironment module and a cell response signal real-time monitoring module. The totally-integrated high-flux cell level micro-fluidic chip medicine evaluating system has the characteristics of total integration, high flux, less sample consumption, totally-closed operation, realization of multi-parameter real time monitoring, and the like, has a very strong original innovativeness, and is of great significance to the large-scale medicine research and development.

The invention discloses a rotating and irrigating type bioreactor system which employs the combination of rotating and irrigating to make the cells distribute more uniformly on the stent surface, promote the transportations of oxygen and nutritious substances into the inner microholes of the stent, keep the activities of the inner cells of the stent. The invention can produce mechanical stress stimulates to the cells by the flow of the culture liquid, regulate the exertion of the cell functions, and realize the real time exchange of the inside and outside gas of the reactor through the semi-permeable membrane on the two ends of the reactor. The invention can provide an excellent, controllable three-dimensional environment for the cell implantation and in vitro culture of cell/stent structural body to realize genuine three-dimensional dynamic culture.