Totally-integrated high-flux cell level micro-fluidic chip medicine evaluating system

A microfluidic chip, cell-level technology, applied in the direction of testing pharmaceutical preparations, laboratory utensils, chemical instruments and methods, etc., can solve the problems of no patent applications, scattered detection objects, and no reports, etc., and achieve consumption The effect of reducing the number of cells, reducing the probability of cell contamination, and shortening the evaluation time

Active Publication Date: 2013-08-21
苏州纳米大健康研究院有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But on the whole, the microfluidic chip system is still in its infancy for drug efficacy evaluation and mechanism research, and the selection, design, optimization and practical application of the chip platform have not really started, and the detection objects are relatively scattered and unreliable. single
In particular, there have been no reports on the development of multi-functional integrated microfluidic drug evaluation systems including fluid control modules, cell culture microenvironment modules, and no related patent applications.

Method used

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  • Totally-integrated high-flux cell level micro-fluidic chip medicine evaluating system
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  • Totally-integrated high-flux cell level micro-fluidic chip medicine evaluating system

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Embodiment

[0022] according to figure 1 A fully integrated high-throughput microfluidic chip drug evaluation system is shown, which consists of four modules. First, follow the figure 2 The functional chip for drug evaluation is shown in the figure. The chip is divided into liquid circuit layer, PDMS film layer, air circuit layer and glass from top to bottom. The first three layers are all PDMS materials, and the layers are sealed with plasma, and the on-chip microvalve is formed through a specific design. Secondly, build a fluid control module consisting of an array of micro-syringe pumps and a micro-valve on a chip. Build the cell culture microenvironment module. This module consists of a cell culture chamber that can be fixed on the microscope stage, a gas control system, and a temperature and humidity control system (such as image 3 shown). Build a real-time monitoring module for cell response signals, which mainly includes three parts: an electronically controlled fluorescence...

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Abstract

A totally-integrated high-flux cell level micro-fluidic chip medicine evaluating system is a multifunctional cell level medicine evaluating system treating a micro-fluidic chip as a core technology, starting from the total design of an integrated high-flux automatic micro-fluidic chip system and integrating a cell function chip module, a flow path control module, a cell culture microenvironment module and a cell response signal real-time monitoring module. The totally-integrated high-flux cell level micro-fluidic chip medicine evaluating system has the characteristics of total integration, high flux, less sample consumption, totally-closed operation, realization of multi-parameter real time monitoring, and the like, has a very strong original innovativeness, and is of great significance to the large-scale medicine research and development.

Description

technical field [0001] The invention belongs to the technical field of cell-level drug evaluation, and in particular provides a fully integrated high-throughput cell-level microfluidic chip drug evaluation system. Background technique [0002] Drug efficacy evaluation and mechanism research are important links in drug innovation, that is, to determine the therapeutic effect and general pharmacological effect of candidate compounds through observation and research on the mechanism of action of candidate compounds, so as to provide a reliable basis for clinical trials of new drugs. The traditional drug evaluation method has low efficiency and high cost in the development of new drugs due to the differences in attributes between animals and animals, between animals and humans, and the limitations of evaluation techniques, which has become one of the bottlenecks in drug development. At present, there are many drug evaluation models. Because the cell level evaluation is closer to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/15B01L3/00
Inventor 秦建华张敏马慧朋
Owner 苏州纳米大健康研究院有限公司
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