A fully integrated high-throughput cell-level microfluidic chip drug evaluation system

Abstract

A totally-integrated high-flux cell level micro-fluidic chip medicine evaluating system is a multifunctional cell level medicine evaluating system treating a micro-fluidic chip as a core technology, starting from the total design of an integrated high-flux automatic micro-fluidic chip system and integrating a cell function chip module, a flow path control module, a cell culture microenvironment module and a cell response signal real-time monitoring module. The totally-integrated high-flux cell level micro-fluidic chip medicine evaluating system has the characteristics of total integration, high flux, less sample consumption, totally-closed operation, realization of multi-parameter real time monitoring, and the like, has a very strong original innovativeness, and is of great significance to the large-scale medicine research and development.

Description

technical field [0001] The invention belongs to the technical field of cell-level drug evaluation, and in particular provides a fully integrated high-throughput cell-level microfluidic chip drug evaluation system. Background technique [0002] Drug efficacy evaluation and mechanism research are important links in drug innovation, that is, to determine the therapeutic effect and general pharmacological effect of candidate compounds through observation and research on the mechanism of action of candidate compounds, so as to provide a reliable basis for clinical trials of new drugs. The traditional drug evaluation method has low efficiency and high cost in the development of new drugs due to the differences in attributes between animals and animals, between animals and humans, and the limitations of evaluation techniques, which has become one of the bottlenecks in drug development. At present, there are many drug evaluation models. Because the cell level evaluation is closer to...

AI Technical Summary

Problems solved by technology

But on the whole, the microfluidic chip system is still in its infancy for drug efficacy evaluation and mechanism research, and the selection, design, optimization and practical application of the chip platform have not really started, and the detection objects are relatively scattered and unreliable. single

In particular, there have been no reports on the development of multi-functional integrated microfluidic drug evaluation systems including fluid control modules, cell culture microenvironment modules, and no related patent applications.

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