98 results about "Oxyde nitrique" patented technology

The invention discloses an ultrasonic activation type piezoelectric gel dressing and a preparation method and application thereof.The surface of a system is an antibacterial hydrogel layer, the antibacterial hydrogel layer is composed of polyethyleneimine (PEI) and polyvinyl alcohol (PVA) cross-linked hydrogel, and ultrasound and current can be transmitted to a deep area; bT-dNO piezoelectric nanoparticles are packaged inside, and BT-dNO is prepared by coating a nitric oxide (NO) donor on the surface of piezoelectric barium titanate (BT) subjected to hydroxylation and dopamine modification. Under the stimulation of low intensity focused ultrasound (LIFU), the donor can release NO as required, and the BT nanoparticles can generate reactive oxygen species (ROS) and output piezoelectric current. The dressing system has an effective combined repair effect, excellent biocompatibility and good anti-inflammatory ability.

Provided herein are compounds of Formula (I), Formula (II), and Formula (III) or pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7 and A are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I), Formula (II), or Formula (III) and methods of using a compound of Formula (I), Formula (II), or Formula (II), e.g., in the treatment of a mental health disease or disorder.

Disclosed is a process for the synthesis of mono- and bis-nitrosylated propanediols, as well as compositions and pharmaceutical formulations that includes the compounds. The process proceeds by reacting a corresponding propanediol that is not nitrosylated with a source of nitrite, optionally in the presence of a suitable acid. When the source of nitrite is an organic nitrite, reacting step is performed in a suitable organic solvent, and when the source of nitrite is an inorganic nitrite, the reacting step is performed in a bi-phasic solvent mixture comprising an aqueous phase and a non-aqueous phase. Also disclosed are methods of treating a condition wherein administration of nitric oxide (NO) has a beneficial effect by administering said compounds, compositions or formulations.

A composition and method of providing nitric oxide and nitrite therapy to patients whereby a therapeutic amount is bioavailable within approximately 30 minutes of administration. In embodiments of the invention, nitric oxide is produced in the oral cavity.

This utility model relates to an innovation of a carotid artery vasodilator that can be used at home and in the emergency room as a supplement to drug treatment for conditions such as carotid artery obstruction in the neck region. It increases the production of nitric oxide mediated by endothelial nitric oxide synthase in the intact endothelial layer of the carotid artery, which is located on the inner surface of the neck brace. It can be applied for a certain period of time for each patient. The intermittent or continuous operation function can be selected through an adjustable power circuit. It only affects the lesion area and does not affect the patient's peripheral blood vessels. It can be used in situations where nitrates may be prohibited. It prevents the reduction of blood flow to the brain tissue that may occur due to jugular venous constriction. The flexible structure of the applicator neck brace (9) can be maintained in the application area for a long time and includes a pulsed magnetic field (PMF).

The present invention relates to the technical field of pharmaceuticals, and in particular to a class of nitric oxide (NO) donor-containing compounds or pharmaceutically acceptable salts, a preparation method therefor, a pharmaceutical composition, and a use thereof in the treatment or prevention of an ocular hypertension-related ophthalmic disease and an optic nerve injury-related disease.

The invention provides a tissue engineering heart valve stent with a sulfonated nano-enzyme coating as well as a preparation method and application of the tissue engineering heart valve stent, and belongs to the technical field of medical materials. The invention relates to a tissue engineering heart valve stent with a sulfonated nano-enzyme coating, which comprises an acellular matrix carrier, ruthenium / iridium-tannic acid nano-enzyme loaded on the acellular matrix carrier, and a sulfonated polymer coating fixed on the acellular matrix carrier and / or the surface of nano-particles through ultraviolet polymerization, the ruthenium / iridium-tannic acid nano-enzyme is formed by tannic acid TA, Ru < 3 + > and Ir < 3 + > through coordination. According to the invention, through double bionic activities of superoxide dismutase and nitric oxide synthase of ruthenium / iridium-tannic acid nano-enzyme and through the super-hydrophilicity and electrically neutral surface of the sulfonated polymer coating, collaborative regulation and control of O2-NO cascade catalysis and interface functions in a pathological microenvironment are realized; the structural and functional in-situ regeneration of the tissue engineering heart valve stent is promoted.

The present application relates to a nitric oxide donor-type compound and use thereof in the preparation of a medicament for preventing and / or treating ophthalmic diseases such as glaucoma and ocular hypertension. The compound has a structure represented by formula (I), or is a stereoisomer, tautomer, solvate, metabolite, pharmaceutically acceptable salt, or prodrug of the structure represented by formula (I).

The invention discloses a cardiovascular stent coating capable of rapidly reconstructing endothelium and releasing nitric oxide for a long time, a preparation method and a stent. The cardiovascular stent coating comprises a dopamine / hexamethylenediamine-copper coating and multiple functional substances combined with the dopamine / hexamethylenediamine-copper coating, and the multiple functional substances comprise an NO precursor, endothelial polysaccharide with the anticoagulation characteristic and growth factors capable of specifically adhering EC. The cardiovascular stent coating provided by the invention is grafted with various functional substances such as endothelial polysaccharide, growth factors capable of specifically adhering EC, NO precursors and the like, so that the defects of low NO yield, poor anticoagulation effect, incapability of quickly promoting re-endothelialization in an early stage and the like of a traditional coating are favorably improved. According to the invention, the cardiovascular stent is endowed with various functions of adhering EC, increasing anticoagulation, providing enough NO under the condition of existence or absence of an endogenous NO donor and the like, so that rapid reendothelialization is promoted, thrombosis and restenosis are prevented, and the long-term curative effect and safety of the cardiovascular stent are finally improved.

A method includes mixing a liquid carrier and a powder formulation including an S-nitrosothiol (RSNO) powder to form a nitric oxide generating solution; and within a predetermined time of mixing, introducing the nitric oxide generating solution into an inflatable and nitric oxide permeable balloon of a urinary catheter that is inserted in a patient.

The present application relates to an activated stem cell microcapsule, a preparation method and application thereof. The activated stem cell microcapsule is prepared by the following method: taking mesenchymal stem cells, culturing the mesenchymal stem cells in a culture medium containing resveratrol, collecting the supernatant, and centrifuging the supernatant by differential centrifugation to obtain the activated stem cell microcapsule; the concentration of the resveratrol in the culture medium is less than 1.5 micromoles per liter. Then the activated stem cell microcapsule is mixed with a nitric oxide donor for incubation to obtain an activated stem cell microcapsule loaded with a nitric oxide donor. The activated stem cell microcapsule and the activated stem cell microcapsule loaded with the nitric oxide donor provided by the present application have good blood vessel repair effect and can be used for preparing a drug for treating peripheral vascular lesions.

The invention relates to a nitric oxide donor based on heparin sodium and a preparation method and application thereof, the method comprises the following steps: (1) dissolving heparin sodium in a 2-(N-morpholino) ethanesulfonic acid buffer solution, adding an activator, and carrying out a reaction to obtain a reaction solution A; (2) adding beta-mercaptoethylamine into the reaction solution A, and continuously reacting to obtain a reaction solution B; (3) dialyzing the reaction solution B to obtain a solution C; and (4) adding tert-butyl nitrite into the solution C, and reacting to obtain the heparin sodium-based nitric oxide donor. Wherein in the step (1), the activating agent is 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide or hydrochloride of the 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide. According to the prepared heparin sodium-based nitric oxide donor, the nitric oxide release time is prolonged, and the problem that the half-life period of nitric oxide is short is solved.

The invention provides a near-infrared light NIR response-based dual-regulation nano drug delivery system and application thereof, the nano drug delivery system takes mesoporous silica as a carrier, and alendronate sodium is coupled on the surface of the carrier to increase bone targeting; mesopores in the carrier are blocked by rhodamine RH, nitric oxide NO can be consumed to generate rhodamine B, and bioactive drugs in the carrier are released. The invention constructs a systemic drug carrier with bone targeting and diabetic bone microenvironment response release, and solves the problems that the bone healing ability of diabetic patients is significantly reduced, and traditional local treatment is difficult to effectively improve systemic bone microenvironment disorder; the problems that an existing local drug system cannot be released according to needs, local NO and NO in bone marrow are difficult to efficiently remove, and macrophages are difficult to transform to repair-promoting M2 type are solved.

The application belongs to the technical field of electrochemical sensing, and particularly relates to an electrochemical sensing electrode with detection and anti-biofouling functions, a preparation method and application thereof. The electrochemical sensing electrode comprises a conductive substrate and a MOF-919 material loaded on the conductive substrate, and function mode switching is realized through external potential regulation. In the detection mode, a first working voltage is applied for nitrite oxidation detection; and a second working voltage is applied to release nitric oxide in situ by reducing nitrite to inhibit microbial adhesion on the electrode surface. The application does not need to additionally set an independent antibacterial layer or add an antibacterial agent, realizes the interface anti-microbial adhesion function while maintaining good electrochemical response performance of the electrode, and significantly improves the stability of long-term use in complex samples. The application provides a new technical path for anti-pollution design of an electrochemical sensing interface.

The invention relates to a nitric oxide donor type compound and application thereof in preparation of drugs for preventing and / or treating ophthalmic diseases such as glaucoma and intraocular hypertension. The compound has a structure as shown in a formula (I), or a stereoisomer, a tautomer, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug of the structure as shown in the formula (I).

The present application relates to a kind of heparin sodium-based nitric oxide donor and its preparation method and application, the method includes the following steps: (1) heparin sodium is dissolved in 2-(N-morpholino) ethanesulfonic acid buffer solution, adding activating agent, reaction is carried out, and reaction liquid A is obtained;(2) to reaction liquid A, continue to react to obtain reaction liquid B by adding β-mercaptoethylamine;(3) reaction liquid B is dialyzed, and solution C is obtained;(4) to solution C, nitrous acid tert-butyl ester is added, and the heparin sodium-based nitric oxide donor is obtained by reaction;Wherein, in step (1), the activating agent is 1-ethyl-3-(3-dimethylaminopropyl) carbonyl diimide or its hydrochloride salt.The heparin sodium-based nitric oxide donor prepared in the present application prolongs the release time of nitric oxide, and solves the problem of short half-life of nitric oxide.

This invention discloses a carrier-free, self-driven nanorobot empowered by nitric oxide, its preparation method, and its applications, belonging to the field of biomedical technology. This invention involves forming a hybrid nanoassembly by driving a nitric oxide donor drug and a photothermal photosensitizer molecule through non-covalent interactions. The surface of the hybrid co-assembled nanoassembly is modified with one or both of polyethylene glycol (PEG) modifiers and PEG thrombofibrin-targeting peptides. The molar ratio of the nitric oxide donor drug to the photothermal photosensitizer molecule is 1:10 to 10:1. The preparation method of this invention is stable, convenient, simple, and practical. The resulting thrombotargeting, nitric oxide donor drug, and photothermal photosensitizer hybrid nanoassembly exhibits extremely high drug loading capacity, enabling efficient co-loading of the hybrid nanoassembly and efficient photothermal-nitric oxide thrombolysis. This provides a novel and efficient drug delivery strategy for the treatment of cerebrovascular diseases such as thrombosis and ischemic stroke.

Provided herein are compounds of Formula (I), Formula (II), and Formula (III) or pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7 and A are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I), Formula (II), or Formula (III) and methods of using a compound of Formula (I), Formula (II), or Formula (III), e.g., in the treatment of a mental health disease or disorder.

The invention relates to the technical field of medicines, in particular to a nano delivery system for treating tumors through immune-chemical kinetics. The hyaluronic acid coated copper peroxide quantum dots are prepared by adopting a one-step method, and hyaluronic acid is used as a stabilizer and a dispersing agent, so that the stability of peroxide can be improved, and the active targeting property is also realized. Meanwhile, the introduction of copper peroxide starts a Fenton-like reaction, and activates a chemical kinetics therapy. In addition, the copper peroxide also reacts with an immunotherapy drug metformin to generate nitric oxide, so that blood vessel normalization is promoted, single-group drug induction is realized, and a pleasant effect of multiple treatments is triggered. In-vivo and in-vitro experimental results show that HMSN-Met-HA-CuO2 has good biological safety and stable nitric oxide release ability, has considerable targeting ability to 4T1 tumor cells, and can effectively inhibit the growth of a tumor model.

The application belongs to the technical field of medical apparatuses, and discloses a nitric oxide breath analyzer, which comprises a front shell, a rear shell assembly and a gas conveying assembly. The front shell has display and human-computer interaction functions. The rear shell assembly comprises a rear shell and a detection structure arranged on the rear shell and used for detecting the content of nitric oxide. The rear shell is arranged on the front shell and forms an installation cavity together with the front shell. The gas conveying assembly is arranged in the installation cavity. The gas conveying assembly can adjust the flow of the detected gas and is arranged in communication with the detection structure, so that the detected gas enters the detection structure through the gas conveying assembly, thereby realizing the modular design of the nitric oxide breath analyzer. Different functional components are located at different positions, thereby reducing the assembly difficulty of the nitric oxide breath analyzer, reducing the assembly cost of the nitric oxide breath analyzer, and further reducing the production cost of the nitric oxide breath analyzer.

The invention discloses a degradable magnesium alloy intravascular stent based on bionic hydrogel and nitric oxide double-path release and a preparation method and application thereof. The method comprises the steps that a magnesium alloy base material is subjected to alkali heat treatment; immersing the treated magnesium alloy into a silane coupling agent for reaction; the photopolymerization reaction liquid is treated to the surface of the silanization modified magnesium alloy, and polymerization is conducted through ultraviolet irradiation; immersing the magnesium alloy with the hydrogel coating into a polyarginine solution, and grafting polyarginine onto the surface of the hydrogel; a sample is activated through EDC / NHS and then immersed in a selenocystamine solution for a reaction, and the bionic composite coating, with the exogenous / endogenous dual-path nitric oxide release function, of the degradable magnesium alloy intravascular stent is obtained. The invention successfully constructs the bionic coating integrating cell membrane-imitating anti-fouling and exogenous / endogenous dual-path NO release functions, and the coating effectively solves the key problems of corrosion control, thrombus formation resistance, functional re-endothelialization coordinated regulation and the like faced by the degradable magnesium alloy intravascular stent.

The embodiment of the invention relates to the technical field of medical coating materials, in particular to a method for forming an active coating on the surface of a degradable plugging device and the degradable plugging device, and the method comprises the following steps: preparing a perfluorohexane liposome loaded with stromal cell-derived factor-1 alpha (SDF-1 alpha); preparing nano particles of the polylactic acid-glycolic acid copolymer, the rapamycin and the nitric oxide donor; preparing a methacryloyl gelatin-tannic acid hydrogel carrier; mixing the liposome and the nanoparticles into the hydrogel carrier; and soaking the degradable plugging device in the mixture obtained in the previous step, and carrying out photo-crosslinking treatment on the mixture, so that an active coating is formed on the surface of the degradable plugging device. Therefore, comprehensive consideration of'implantation early endothelial repair-implantation later cardiac muscle tissue remodeling 'is realized, controllable sequential repair of the degradable plugging device on the heart defect part is ensured, and the endogenous function repair effect of the heart of a patient is improved.

The application discloses a nitric oxide liposome hydrogel drug delivery system for treating alopecia, and a preparation method and application thereof, and belongs to the technical field of alopecia treatment. The application uses a slow-release NO donor material Cho-SNO as a part of the liposome hydrogel drug delivery system, and makes the NO-releasing liposome hydrogel participate in liposome assembly as a liposome skeleton molecule, so that the NO-releasing liposome hydrogel and the loaded therapeutic drug are synergistic, thereby effectively promoting hair growth and prolonging the hair growth period, and showing important application prospects for treating diseases related to NO synergistic drug treatment. Meanwhile, the transdermal delivery of the therapeutic drug is carried out through the drug delivery system, the stability and long-term performance of the drug are improved, and the side effects such as short drug storage time in the skin, difficulty in continuously exerting the curative effect, causing other parts of the body to be hairy, and blood pressure reduction are improved. The hydrogel is used as a carrier, has good biological safety, and is suitable for the physiological environment of human skin.

The disclosed embodiments relate to a wound dressing that can generate nitric oxide. The wound dressing may include: a cover layer; an activator layer, such as an acid providing layer; and a nitrite providing layer. The activator layer may include acidic groups and may be a hydrogel, xerogel, or other suitable material. The nitrite providing layer may include a mesh component embedded with nitrite and an antioxidant / reducing agent, such as sodium erythorbate. The nitrite ions of the nitrite providing layer can react with the acidic groups of the activation layer to generate nitric oxide. In addition, wound dressings can be produced and stored such that degradation of antioxidants / reductants is reduced and thus stable nitric oxide production is achieved.

Disclosed is a multiphasic mixture that generates nitric acid in situ for the treatment of topical dermatological conditions.

A method for enhancing or improving muscle functions and / or improving athletic performance and / or preventing or relieving fatigue and / or increasing or improving a nitric oxide signal or level, comprising: administering a citrulline dipeptide or a salt, ester, and derivative thereof to a subject.

The present application relates to a kind of meat product colorant based on double enzyme cascade reaction and coloration method and application, belong to meat science and technology field.The meat product colorant is composed of recombinant glucose dehydrogenase and one oxygen fusion enzyme NOS-YkuN-YumC of producing nitric oxide.The present application is by constructing the nicotinamide adenine dinucleotide phosphate (NADPH) regeneration system based on glucose dehydrogenase in recombinant bacillus subtilis, realize the continuous supply of key cofactor NADPH, to significantly enhance the catalytic activity of one oxygen fusion enzyme NOS-YkuN-YumC of producing nitric oxide under low temperature condition.It is applied to meat product, and the produced one oxygen is combined with myoglobin efficiently, generates nitrosylmyoglobin, so that meat product can obtain ideal red color even in low temperature processing with sodium nitrite treatment.The present application provides efficient and feasible solution for replacing nitrite coloration and improving meat product safety.

The invention belongs to the technical field of biomedical composite materials, and discloses a copper-based MOF modified small-caliber polyurethane artificial blood vessel and a preparation method. The copper-based metal organic framework is used as a functional carrier to be compounded with polyurethane, the artificial blood vessel with the inner diameter smaller than or equal to 6 mm is prepared through the electrostatic spinning technology, and synergistic release of copper ions, nitric oxide and medicine molecules is achieved; the preparation process comprises the steps of synthesis of the copper-based metal organic framework, preparation of a polyurethane solution, drug loading, electrostatic spinning forming and the like. According to the invention, a mechanical adaptation-biological regulation synergistic system is innovatively constructed, so that proliferation of endothelial cells is effectively promoted, excessive proliferation of smooth muscle cells is inhibited, and an ideal microenvironment is provided for vascular repair; the clinical problems of mechanical property mismatch, thrombosis, intimal hyperplasia and the like of the small-caliber artificial blood vessel are solved, and the preparation method is stable in process and low in cost and has important clinical application value.

The application relates to the technical field of nitrite synthesis, and discloses a synthesis method and a synthesis device of alkyl nitrite. The synthesis method comprises the following steps: firstly, mixing gaseous nitric oxide and gaseous oxygen to obtain a mixture through a first reaction; and then, mixing the mixture with alkyl alcohol to obtain alkyl nitrite through a second reaction. The synthesis method greatly shortens the reaction time, increases the yield of alkyl nitrite, does not have a complicated post-treatment process and a large amount of by-product nitric acid, and is beneficial to cost saving and time saving.