82 results about "Thianaphthene" patented technology

The invention relates to a compound containing a thiophene group, a device and equipment. In the structural formula of the compound, R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are independently selected from hydrogen, halogen, cyano, trifluoromethyl, triphenylamine and derivatives thereof, methoxyl, aryl and derivatives thereof, cyanobiphenyl and naphthyl; the compound can be used for preparing a photovoltaic device and photovoltaic equipment and is used for improving the efficiency and stability of the photovoltaic device.

The invention relates to the technical field of organic synthesis and the technical field of fluorescent materials, in particular to a boron coordination salicylhydrazone double-state emission fluorophore as well as a preparation method and application of the boron coordination salicylhydrazone double-state emission fluorophore. The structure of the boron coordination salicylazone double-state emission fluorophore is shown as I, II or III; wherein R1 is selected from one of H, halogen atoms, diethylamino and thienyl, R2 is selected from one of H, halogen atoms, diethylamino and thienyl, and R3 is selected from one of aryl, 9, 9 '-spirobifluorenyl, alkoxy and halogen atoms. The boron coordination salicylazone double-state emission fluorophore is diversified in structure and good in solubility, has excellent photophysical properties and extremely high quantum yield, and also shows excellent biocompatibility and remarkable liposome targeting property at the same time. Moreover, the preparation method of the boron-coordinated salicylazone double-state emission fluorophore adopts a one-pot two-step method, is simple and convenient, is high in yield, is green and environment-friendly, and has a wide application prospect.

The invention provides a synthesis method of a thioether ligand and a palladium-catalyzed 2-aryl indole compound, and designs an application of the biphenyl thioether ligand and a palladium catalyst in preparation of the 2-aryl indole compound. Indole and arylboronic acid are subjected to a reaction under the action of a palladium catalyst and a biphenyl sulfide ligand, and the structural formula of the biphenyl sulfide ligand is shown in the specification. Ar is phenyl, furyl, thienyl, naphthyl or phenyl substituted by one or more substituent groups; r1 is methyl, methoxyl, fluorine atom, chlorine atom, bromine atom or methyl ester group; r2 is the same or different and is methyl, ethyl, isopropyl, isobutyl, cyclohexyl, benzyl, n-butyl or n-hexyl; r3 is alkoxy, alkylthio, substituted amino or halogen; the palladium catalyst is a divalent palladium compound.

The application discloses two kinds of metal organic framework materials Zr-TTB-1 and Zr-TTB-2, a preparation method thereof and application thereof in methane adsorption. The preparation method comprises the following steps: firstly, synthesizing an organic ligand TTB containing a five-membered thiophene ring under specific and suitable conditions by taking 1,3,5-tri(thiophene-2-yl) benzene as a raw material; and then preparing stable two kinds of metal organic framework materials under specific and suitable conditions by combining the organic ligand TTB with a Zr6 metal cluster. The synthesis and preparation method route is simple, the operation is simple, the cost is low, and the method is suitable for efficient methane adsorption and storage.

The invention relates to the technical field of organic synthesis, and particularly provides a thiophene-containing tetraarylethene compound as well as a preparation method and application thereof. According to the invention, two phenyl groups of tetraphenylethylene are replaced by methyl formate thiophene groups, and the substituted tetraarylethylene compound has more remarkable photochromic and mechanochromic dual functions through the interaction of a specific substituent group at the position 2 of thiophene and a large conjugated group formed by four aromatic rings; and light-operated double-color display in a polymer mechanism can be realized. The mechanochromism of the compound does not depend on ultraviolet light, when the compound is subjected to mechanical force, the molecular accumulation mode and conjugate planarity are changed, and the color change can be directly observed by naked eyes. Different from traditional tetraphenyl ethylene force-induced discoloration recessive fluorescence change, the dominant color change can be used in the fields of visual stress monitoring, anti-counterfeiting marks, inkless writing materials, safe ink and the like in ultraviolet-free environments (such as indoor and closed spaces), and the application prospect is wide.

This application relates to a terphenylamine skeleton compound, its preparation method, and its application, belonging to the field of chemical synthesis technology. The preparation method of the terphenylamine skeleton compound of this application includes the following steps: dissolving 2,4,6-triphenylaniline with thiazole-4-carboxaldehyde or thiophene-3-carboxaldehyde in a solvent, conducting a reductive amination reaction under reducing agent conditions, quenching, extraction, washing, concentration to remove solvent, and purification to obtain the terphenylamine skeleton compound. This application provides a simple and mild synthetic method for the natural active products 5'-phenyl-N-(thiazol-4-ylmethyl)-[1,1':3',1''-terphenyl]-2'-amine and 5'-phenyl-N-(thiophene-3-ylmethyl)-[1,1':3',1''-terphenyl]-2'-amine, which can only be extracted from the secondary metabolites of the marine fungus Aspergillus sp. Furthermore, this method utilizes widely available raw materials, which is beneficial for large-scale industrial production of these natural active products.

The invention relates to a 2-cyanopyrrole compound as well as a preparation method and application thereof. The structural formula of the 2-cyanopyrrole compound is as follows: # imgabs0 #, in the formula, R1 is selected from any one of phenyl, 4-methylphenyl, 4-chlorphenyl, 2, 4-dichlorophenyl, cyclopropyl or tert-butyl, and R2 is selected from any one of phenyl, 4-methylphenyl, 4-chlorphenyl, 2, 4-dichlorophenyl, cyclopropyl or tert-butyl; r1 is selected from any one of phenyl, 3-fluorophenyl, 4-methoxyphenyl, 2-thienyl or 2-naphthyl, and R2 is selected from any one of phenyl, 3-fluorophenyl, 4-methoxyphenyl, 2-thienyl or 2-naphthyl. Compared with the prior art, the method has the advantages of simple and easily available raw materials, simple reaction operation, environmental friendliness and the like. The 2-cyanopyrrole compound synthesized by the method disclosed by the invention has a wide application prospect in the related fields of organic synthesis, medicinal chemistry and the like.

The application provides a preparation method of a dihydroquinazoline compound and belongs to the technical field of organic synthesis. 1 comprises hydrogen, methyl, tert-butyl, methoxy or halogen; R 2 comprises phenyl; R 3 comprises phenyl; R 4 comprises phenyl, p-tolyl, p-methoxyphenyl, o-tolyl, p-fluorophenyl, p-chlorophenyl, naphthyl, pyridyl or thienyl; Ar comprises phenyl, naphthyl or pyridyl; R 5 comprises phenyl, cyclopropyl, cyclohexyl or [1,1'-biphenyl]-4-yl. The preparation method provided by the application has the advantages of short reaction route, no need to add a transition metal catalyst, good functional group compatibility, high yield, high production efficiency and green environmental protection.

The present invention discloses a thiophene-substituted aza-fluoro-boron-dipyrrole compound, nanoparticles of the compound, and their preparation methods and applications. The thiophene-substituted aza-fluoro-boron-dipyrrole compound designed and synthesized by the present invention, the introduction of the thiophene group can significantly red-shift the absorption spectrum of aza-fluoro-boron-dipyrrole, successfully red-shifting to the 810nm near-infrared region, which is more conducive to its application in vivo and in photothermal therapy. Nanoparticles prepared with this compound as the core can be effectively distributed to visceral adipose tissue after local intraperitoneal administration, selectively targeting visceral adipose tissue, have good biocompatibility and high photothermal conversion efficiency, can achieve temperature regulation by adjusting its concentration and 808nm laser power, and can be used for photothermal treatment of obesity.

The invention discloses a kind of recycling polypropylene to prepare high-impact material and preparation method thereof, relate to the field of materials. When the present invention uses recycling polypropylene to prepare high-impact material, first, polypropylene is grafted with vinyl diphenylphosphine, then reacted with 1-(3-chlorophenyl)-2-propyn-1-ol, and then reacted with 6-(methyl formate) pyridine-3-boric acid to obtain modified polypropylene; Secondly, calcium carbonate pretreated with 3-aminopropyltrimethoxysilane and 3-thiophene carboxaldehyde are reacted, and thiophene, 6-(thiophene-2-yl) pyridine-2-carboxylic acid, and 6-(3-thienyl) pyridine-2-carboxaldehyde are polymerized on the surface of calcium carbonate to obtain modified calcium carbonate; Finally, recycled polypropylene, modified polypropylene, modified calcium carbonate, sodium cyanide, and bismaleimide are melt-blended, and then extrusion granulation is performed to obtain high-impact material; The high-impact material prepared by the present invention has good impact resistance, anti-aging performance and antibacterial performance.

The present invention relates to a new scheme and process for the preparation of one specific SIK3 inhibiting compound known as (and described herein as) “E9”. Compound E9 has previously been described by the present applicant to show surprisingly superior drug-like properties, such as in respect of target-potency / specificity and ADMET / PK properties, compared to other prior art SIK3 inhibiting compound. The present invention also relates to novel intermediates used in such process of preparing compound E9, as well as to a new methodology used within the process of producing a characteristic key thiophene-based amino intermediate that is used to produce compound E9, and other related aspects as disclosed herein.

The application discloses chiral bis-thiophene-bis-nitrogen-oxygen ligands BbTh-2NO and BTh-2NO. The ligands comprise bis-thiophene groups and nitrogen-oxygen groups (sulfur atoms of the bis-thiophene and oxygen atoms of the nitrogen-oxygen groups belong to electron-rich coordination sites), can form six-membered ring coordination with Lewis acid soft metal palladium, thereby generating chiral ligand metal palladium complexes, and are applied as chiral ligands in asymmetric catalytic reactions. Therefore, the application has important application value in the field of asymmetric catalytic synthesis, and a synthesis method thereof is very economical and simple. The application also has good air stability, wide applicability and good compatibility for various substituents.

The invention belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of brexpiprazole. The preparation method comprises the following steps: by taking a compound 4-amino benzo [b] thiophene and chloroacetaldehyde as starting materials, carrying out substitution reaction to prepare an intermediate 2, 2 '-(benzo [b] thiophene-4-yl azane diyl) diacetaldehyde, and then carrying out reductive amination reaction on the intermediate 2, 2'-(benzo [b] thiophene-4-yl azane diyl) diacetaldehyde and 7-(4-amino butoxy) quinoline-2 (1H)-ketone to construct a piperazine ring, thereby preparing the target product bupremizole I, the product obtained by the process has high yield and purity, and is suitable for industrial production.

The invention discloses a preparation method of a key intermediate epoxide of rubaburon, and belongs to the technical field of organic synthesis. The method comprises the following steps: (1) adding a solvent, 2-(2-bromophenyl) thiophene and a basic catalyst into a reaction container, dropwise adding glycidol while stirring, and continuously reacting after dropwise adding until the 2-(2-bromophenyl) thiophene is completely reacted; and (2) cooling and filtering to remove salt, concentrating filtrate to be dry, adding methanol, heating and dissolving, cooling and crystallizing, filtering and drying to obtain the 2-((2-thiophene-2-yl) phenoxy) methyl) ethylene oxide. According to the invention, new raw materials and a new synthetic route are selected to prepare the key intermediate epoxide of the rubaburon, the production process is simple, and the key intermediate epoxide of the rubaburon, which is higher in yield, less in side reaction and lower in cost, is obtained.

The application belongs to the technical field of pharmaceutical preparations, and particularly relates to a pharmaceutical composition of avibactam sodium and a preparation method thereof. The pharmaceutical composition comprises the following components: avibactam sodium, 2-(5-(2-oxoazetidin-1-yl)thiophene-2-yl)benzo[d]thiazole-6-carboxylic acid; the mass ratio of the avibactam sodium and the 2-(5-(2-oxoazetidin-1-yl)thiophene-2-yl)benzo[d]thiazole-6-carboxylic acid is 1:(2-3). The pharmaceutical composition has a significant synergistic antibacterial effect.

The present invention relates to a substituted thienyl-5-fluoro-1H-pyrazolopyridine compound and a use thereof. The present invention specifically relates to a compound as shown in a formula (I), a preparation method for the compound, a pharmaceutical composition and a combination product containing the compound, and a use of the compound, the pharmaceutical composition or the combination product in preparation of drugs for treating and / or preventing diseases such as heart failure.

This invention relates to the field of pharmaceutical synthesis technology, specifically to a method for synthesizing key intermediates of telexamine, aiming to solve the problems of expensive raw materials, high pollution, high safety risks, and unsuitability for industrial production in existing telexamine intermediate synthesis processes. The key intermediates of this invention are 2-(2-thienyl)cyclohexanone and 2-bromo-2-(2-thienyl)cyclohexanone. The synthesis method uses thiophene and cyclohexanecarboxylic acid as starting materials, and obtains 2-(2-thienyl)cyclohexanone through a solvent-free condensation reaction mediated by polyphosphoric acid, followed by bromination with a brominating reagent and purification in an alcohol phase to obtain 2-bromo-2-(2-thienyl)cyclohexanone. This invention uses inexpensive and readily available raw materials, operates under mild conditions, is simple to operate, is environmentally friendly and safe, and achieves a target product yield of up to 73% and an HPLC purity of up to 98.22%, significantly reducing the synthesis cost of telexamine and making it suitable for large-scale industrial production.

The invention belongs to the technical field of medicine synthesis, and particularly relates to an efficient synthesis method of brexpiprazole. The invention provides a novel preparation method of bupreprazole, which comprises the following steps: by taking 1-(benzo [b] thiophene-4-yl)-4-(4-bromobutyl) piperazine as a starting material, carrying out substitution reaction on the 1-(benzo [b] thiophene-4-yl)-4-(4-bromobutyl) piperazine and 7-hydroxy-2H-benzopyran-2-ketone to prepare an intermediate 7-(4-(4-(benzo [b] thiophene-4-yl) piperazin-1-yl) butoxy)-2H-benzopyran-2-ketone; according to the present invention, with the process, the use of the noble metal catalyst and the generation of the related dimer and the heterotopic substitution impurity can be effectively avoided, and the product obtained through the process has characteristics of high yield and high purity, and is suitable for industrial production.

The invention discloses a method for preparing propionate through ethylene hydrogen esterification reaction, which is characterized in that raw materials ethylene, carbon monoxide and low-carbon alcohol are subjected to hydrogen esterification reaction in the presence of a catalyst by taking propionate as a solvent to synthesize propionate, the catalyst is composed of a palladium compound, a naphthyl bidentate phosphine ligand and an acidic auxiliary agent, and the structure of the naphthyl bidentate phosphine ligand is shown in the following formula. Wherein m is 0 or 1, and n is 1 or 2; r1 is selected from phenyl, tertiary butyl, cyclohexyl, 2-pyridyl, 2-thienyl or 2-furyl, and R2 is selected from tertiary butyl, cyclohexyl, 2-pyridyl, 2-thienyl or 2-furyl. According to the method, the naphthyl bidentate phosphine is used as the ligand, the product propionate is used as the reaction solvent, the catalyst activity is high, the yield of the target product propionate is high, and byproducts are few.

The present invention relates to a salt and crystal form of an AT2R agonist and use thereof in pharmaceutics, and specifically relates to a salt and crystal form of methyl ((4-fluoro-5-isobutyl-3-(4-((2-(trifluoromethyl)-1H-imidazol-1-yl)methyl)phenyl)thiophen-2-yl)sulfonyl)carbamate (a compound represented by formula (I)) and use thereof in pharmaceutics.

The present invention relates to the technical field of chemical pesticides, and in particular to an organic phosphine compound, a preparation method therefor, and a use thereof. The structural formula of the organic phosphine compound is as represented by formula (I), wherein R1 and R2 are respectively C1-C6 alkyl and C1-C6 alkoxy, or R1, R2, and P are connected to each other to form a six-membered ring; R3 is hydrogen, methyl, ethyl, propyl, furyl, thienyl, pyridyl, phenyl, 4-chlorophenyl, 2,4-dichlorophenyl, 3,4-dichlorophenyl, or 4-methylphenyl; R4, R5, and R6 each are hydrogen, C1-C3 alkyl, or halogen; and X is C or N. The organic phosphine compound can effectively prevent and control the growth of broadleaf weeds and gramineous weeds post-emergently and has relatively good herbicidal activity. The overall herbicidal activity is higher than that of clacyfos, the herbicidal spectrum of the organic phosphine compound is wider, and the inhibitory activity on various weeds is superior to that of glyphosate. The organic phosphine compound has good application value.

The invention discloses an anti-tumor 1, 2, 3-triazole-alpha-L-threose nucleoside phosphonate compound as well as a preparation method and application thereof, and the 1, 2, 3-triazole-alpha-L-threose nucleoside phosphonate analogue has a chemical structure as shown in a general formula 1, r1 is phenyl, 2-methylphenyl, 3-methylphenyl, 4-ethylphenyl, 4-propylphenyl, 2-chlorphenyl, 3-chlorphenyl, 4-chlorphenyl, 4-bromophenyl, 3-fluorophenyl, 3-nitrophenyl, 4-methoxyphenyl, 4-cyanophenyl, 3, 4-dichlorophenyl, 3, 4-dichlorophenyl, 3, 4-dichlorophenyl, 3, 4-dichlorophenyl, 3, 4-dichlorophenyl, 3, 4-dichlorophenyl, 3, 4-dichlorophenyl, 3, 4-dichlorophenyl, 3, 4-dichlorophenyl, 3, 4-dichlorophenyl, 3, 4-dichlorophenyl R1, R2, R3, R4, R5, R6, R7, R7, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, the technical route for preparing the 1, 2, 3-triazole-alpha-L-threose nucleoside phosphonate compound is simple to operate, concise in route and relatively high in yield, the used reagents are common reagents and suitable for large-scale preparation, and in-vitro antitumor activity research finds that the compound has good antitumor activity and can be used for preparing the 1, 2, 3-triazole-alpha-L-threose nucleoside phosphonate compound. The compound is expected to be used as an anti-tumor drug or a primer of the anti-tumor drug.

The invention provides an aggregation-induced emission (AIE) ionic probe (E)-4-(2-(5-(4-(diphenylamino) phenyl) thiophene-2-yl) vinyl)-1-(4-sulfanilamide acyl benzyl) quinoline-1-onium hexafluorophosphoric acid (V) salt of a targeted golf apparatus, namely a fluorescent probe TTQ-GA, a preparation method of the fluorescent probe TTQ-GA and application of the fluorescent probe TTQ-GA in the aspect of detection. The benzenesulfonamide group of the probe can be selectively combined with a Golgi apparatus protein cyclooxygenase 2 (COX-2) inhibitor SC-558 to realize Golgi apparatus targeting; due to the hydrophobic triphenylamine part and the hydrophilic quinoline cation part of the probe, the probe has amphipathy; the probe does not emit fluorescence in an aqueous solution, and can emit strong fluorescence when molecular movement is limited and excited, so that no-wash marking of the Golgi apparatus is realized; the probe generates a large amount of ROS under light excitation, promotes local lipid peroxidation increase of Golgi apparatus, and promotes cancer cell apoptosis.

The present application relates to the technical fields, specifically relates to a kind of synthetic method of lotilana, including, with 3-methyl thiophene as starting material, by eight-step reaction lotilana is prepared, specific steps are as follows: first step: 3-methyl thiophene is made into intermediate 2-chloromethyl-3-methyl thiophene by Blanc chloromethylation reaction;Second step: 2-chloromethyl-3-methyl thiophene is made into intermediate 1-(5-(chloromethyl)-4-methyl thiophene-2-yl) ethanone by Friedel-Crafts acylation reaction with acetyl chloride;Third step: 1-(5-(chloromethyl)-4-methyl thiophene-2-yl) ethanone is made into intermediate 2-hydroxymethyl-3-methyl-5-acetyl thiophene by sodium carbonate hydrolysis;Eighth step: 3-methyl-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3-yl) thiophene-2-yl) methyl cyanide is made into lotilana by Ritter reaction with 2-chloro-N-(2,2,2-trifluoroethyl) acetamide;High atomic economy;Raw material is cheap and easy to obtain;No dangerous process.

The invention relates to a thiophene-modified copper-cluster metal covalent organic framework material and application of the thiophene-modified copper-cluster metal covalent organic framework material in photocatalysis of organic conversion of thioamide into thiadiazole. According to the invention, a cyclic trinuclear copper cluster unit is used as a raw material, and the cyclic trinuclear copper cluster unit, 2, 5-bis (thiophene-2-yl) benzene-1, 4-diamine (alpha SPA) and 2, 5-bis (thiophene-3-yl) benzene-1, 4-diamine (beta SPA) are prepared into two types of thiophene modified copper cluster metal covalent organic framework (M-COF) materials with efficient charge separation efficiency through a solvothermal method. The material is applied to the field of photocatalytic organic conversion, and thioamide cyclization and conversion of derivatives of thioamide are achieved under irradiation of a white light LED. The prepared M-COF has excellent charge separation efficiency and electron mobility, the catalyst is applied to performance research of photocatalytic thioamide cyclization reaction, and the synthesis strategy of the catalyst has wide substrate universality and functional group compatibility. The activity is not obviously attenuated after continuous and repeated recycling, and the efficient and sustainable photocatalytic conversion performance is manifested.

The application discloses a bipolar polymer semiconductor material containing difluoro-substituted indathrene and a preparation method and application thereof. N The copolymerization of the obtained copolymer monomer and 5,5'- (bistrimethyltinyl) -2,2'-dithiophene or (E) -1,2- (5- (bistrimethyltinyl) -thiophene-2-yl) ethylene, a centrosymmetric monomer, through a bromination reaction of bromo-succinimide to obtain a novel bipolar polymer semiconductor material containing difluoro-substituted indathrene with a D-A configuration. The synthesis route of the application is simple and efficient, raw materials are easy to obtain, the cost is low, the universality is high, and the repeatability is good. The material has the advantages of good solubility, excellent thermal stability and strong absorption spectrum range. The bipolar polymer semiconductor material prepared by the application is used as an active layer material, and an organic field effect transistor device prepared by the application has excellent electrical performance. The material has broad commercial prospects in organic thermoelectricity, organic field effect transistors, organic logic complementary circuits and other optoelectronic devices.

The invention discloses a duloxetine hydrochloride key intermediate synthesis method, which comprises: in a hydrogen atmosphere, under the action of a compound represented by a formula V, carrying out an asymmetric catalytic hydrogenation reaction on a compound represented by a formula I to obtain a compound represented by a formula II, the method has the advantages of mild reaction conditions, simple operation, high catalytic efficiency, high yield, high product purity and high ee value, and is very suitable for industrialization.

The invention discloses a D-A type covalent organic framework material as well as a preparation method and application of the D-A type covalent organic framework material. The material is obtained through aldehyde amine condensation by using N, N ', N'-tetra (p-aminophenyl) p-phenylenediamine (TAPB) as a donor unit and 3, 6-bis (5-aldehyde thiophene-2-yl)-2, 5-bis (2-ethylhexyl) pyrrolo [3, 4-c] pyrrolo [3, 4-c] pyrrole-4 (2H, 5H)-diketone (DSZ) as an acceptor unit, and the material is of a two-dimensional layered porous structure, is dark blue and has reversible switching electrochromic performance from dark blue to nearly transparent color. According to the invention, a donor-receptor type covalent organic framework structure is constructed through TAPB and DSZ, and reversible color change from dark blue to nearly colorless in a near-infrared region is realized by using synergistic oxidation reduction of a D-A unit and charge transfer characteristics of a conjugated framework.

The present invention discloses a 4,5,6,7-tetrahydro-1H-benzimidazole-1-ylmethanol compound and its preparation method and application. The compound of the present invention has a structure shown in Formula I or Formula II: wherein: R is selected from C 1‑6 Alkyl, C 3‑6 Cycloalkyl, 5-6 membered heterocyclic groups, such as furyl, thienyl, pyrrolyl, and pyridyl. The present invention structurally modifies the 4,5,6,7-tetrahydro-1H-benzimidazol-1-ylmethanol core with an organic acid (such as furanoic acid) to obtain a (4,5,6,7-tetrahydro-1H-benzimidazol-1-yl)methanol compound with excellent corrosion resistance. The compound of the present invention can prevent metal corrosion in an alkaline environment and the pH value of the test solution does not decrease significantly.