57 results about "Thianaphthene" patented technology

The invention relates to a compound containing a thiophene group, a device and equipment. In the structural formula of the compound, R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are independently selected from hydrogen, halogen, cyano, trifluoromethyl, triphenylamine and derivatives thereof, methoxyl, aryl and derivatives thereof, cyanobiphenyl and naphthyl; the compound can be used for preparing a photovoltaic device and photovoltaic equipment and is used for improving the efficiency and stability of the photovoltaic device.

The invention provides a synthesis method of a thioether ligand and a palladium-catalyzed 2-aryl indole compound, and designs an application of the biphenyl thioether ligand and a palladium catalyst in preparation of the 2-aryl indole compound. Indole and arylboronic acid are subjected to a reaction under the action of a palladium catalyst and a biphenyl sulfide ligand, and the structural formula of the biphenyl sulfide ligand is shown in the specification. Ar is phenyl, furyl, thienyl, naphthyl or phenyl substituted by one or more substituent groups; r1 is methyl, methoxyl, fluorine atom, chlorine atom, bromine atom or methyl ester group; r2 is the same or different and is methyl, ethyl, isopropyl, isobutyl, cyclohexyl, benzyl, n-butyl or n-hexyl; r3 is alkoxy, alkylthio, substituted amino or halogen; the palladium catalyst is a divalent palladium compound.

The application discloses two kinds of metal organic framework materials Zr-TTB-1 and Zr-TTB-2, a preparation method thereof and application thereof in methane adsorption. The preparation method comprises the following steps: firstly, synthesizing an organic ligand TTB containing a five-membered thiophene ring under specific and suitable conditions by taking 1,3,5-tri(thiophene-2-yl) benzene as a raw material; and then preparing stable two kinds of metal organic framework materials under specific and suitable conditions by combining the organic ligand TTB with a Zr6 metal cluster. The synthesis and preparation method route is simple, the operation is simple, the cost is low, and the method is suitable for efficient methane adsorption and storage.

The invention relates to the technical field of organic synthesis, and particularly provides a thiophene-containing tetraarylethene compound as well as a preparation method and application thereof. According to the invention, two phenyl groups of tetraphenylethylene are replaced by methyl formate thiophene groups, and the substituted tetraarylethylene compound has more remarkable photochromic and mechanochromic dual functions through the interaction of a specific substituent group at the position 2 of thiophene and a large conjugated group formed by four aromatic rings; and light-operated double-color display in a polymer mechanism can be realized. The mechanochromism of the compound does not depend on ultraviolet light, when the compound is subjected to mechanical force, the molecular accumulation mode and conjugate planarity are changed, and the color change can be directly observed by naked eyes. Different from traditional tetraphenyl ethylene force-induced discoloration recessive fluorescence change, the dominant color change can be used in the fields of visual stress monitoring, anti-counterfeiting marks, inkless writing materials, safe ink and the like in ultraviolet-free environments (such as indoor and closed spaces), and the application prospect is wide.

This application relates to a terphenylamine skeleton compound, its preparation method, and its application, belonging to the field of chemical synthesis technology. The preparation method of the terphenylamine skeleton compound of this application includes the following steps: dissolving 2,4,6-triphenylaniline with thiazole-4-carboxaldehyde or thiophene-3-carboxaldehyde in a solvent, conducting a reductive amination reaction under reducing agent conditions, quenching, extraction, washing, concentration to remove solvent, and purification to obtain the terphenylamine skeleton compound. This application provides a simple and mild synthetic method for the natural active products 5'-phenyl-N-(thiazol-4-ylmethyl)-[1,1':3',1''-terphenyl]-2'-amine and 5'-phenyl-N-(thiophene-3-ylmethyl)-[1,1':3',1''-terphenyl]-2'-amine, which can only be extracted from the secondary metabolites of the marine fungus Aspergillus sp. Furthermore, this method utilizes widely available raw materials, which is beneficial for large-scale industrial production of these natural active products.

The application provides a preparation method of a dihydroquinazoline compound and belongs to the technical field of organic synthesis. 1 comprises hydrogen, methyl, tert-butyl, methoxy or halogen; R 2 comprises phenyl; R 3 comprises phenyl; R 4 comprises phenyl, p-tolyl, p-methoxyphenyl, o-tolyl, p-fluorophenyl, p-chlorophenyl, naphthyl, pyridyl or thienyl; Ar comprises phenyl, naphthyl or pyridyl; R 5 comprises phenyl, cyclopropyl, cyclohexyl or [1,1'-biphenyl]-4-yl. The preparation method provided by the application has the advantages of short reaction route, no need to add a transition metal catalyst, good functional group compatibility, high yield, high production efficiency and green environmental protection.

The invention belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of brexpiprazole. The preparation method comprises the following steps: by taking a compound 4-amino benzo [b] thiophene and chloroacetaldehyde as starting materials, carrying out substitution reaction to prepare an intermediate 2, 2 '-(benzo [b] thiophene-4-yl azane diyl) diacetaldehyde, and then carrying out reductive amination reaction on the intermediate 2, 2'-(benzo [b] thiophene-4-yl azane diyl) diacetaldehyde and 7-(4-amino butoxy) quinoline-2 (1H)-ketone to construct a piperazine ring, thereby preparing the target product bupremizole I, the product obtained by the process has high yield and purity, and is suitable for industrial production.

The application belongs to the technical field of pharmaceutical preparations, and particularly relates to a pharmaceutical composition of avibactam sodium and a preparation method thereof. The pharmaceutical composition comprises the following components: avibactam sodium, 2-(5-(2-oxoazetidin-1-yl)thiophene-2-yl)benzo[d]thiazole-6-carboxylic acid; the mass ratio of the avibactam sodium and the 2-(5-(2-oxoazetidin-1-yl)thiophene-2-yl)benzo[d]thiazole-6-carboxylic acid is 1:(2-3). The pharmaceutical composition has a significant synergistic antibacterial effect.

This invention relates to the field of pharmaceutical synthesis technology, specifically to a method for synthesizing key intermediates of telexamine, aiming to solve the problems of expensive raw materials, high pollution, high safety risks, and unsuitability for industrial production in existing telexamine intermediate synthesis processes. The key intermediates of this invention are 2-(2-thienyl)cyclohexanone and 2-bromo-2-(2-thienyl)cyclohexanone. The synthesis method uses thiophene and cyclohexanecarboxylic acid as starting materials, and obtains 2-(2-thienyl)cyclohexanone through a solvent-free condensation reaction mediated by polyphosphoric acid, followed by bromination with a brominating reagent and purification in an alcohol phase to obtain 2-bromo-2-(2-thienyl)cyclohexanone. This invention uses inexpensive and readily available raw materials, operates under mild conditions, is simple to operate, is environmentally friendly and safe, and achieves a target product yield of up to 73% and an HPLC purity of up to 98.22%, significantly reducing the synthesis cost of telexamine and making it suitable for large-scale industrial production.

The invention discloses a method for preparing propionate through ethylene hydrogen esterification reaction, which is characterized in that raw materials ethylene, carbon monoxide and low-carbon alcohol are subjected to hydrogen esterification reaction in the presence of a catalyst by taking propionate as a solvent to synthesize propionate, the catalyst is composed of a palladium compound, a naphthyl bidentate phosphine ligand and an acidic auxiliary agent, and the structure of the naphthyl bidentate phosphine ligand is shown in the following formula. Wherein m is 0 or 1, and n is 1 or 2; r1 is selected from phenyl, tertiary butyl, cyclohexyl, 2-pyridyl, 2-thienyl or 2-furyl, and R2 is selected from tertiary butyl, cyclohexyl, 2-pyridyl, 2-thienyl or 2-furyl. According to the method, the naphthyl bidentate phosphine is used as the ligand, the product propionate is used as the reaction solvent, the catalyst activity is high, the yield of the target product propionate is high, and byproducts are few.

The present invention relates to a salt and crystal form of an AT2R agonist and use thereof in pharmaceutics, and specifically relates to a salt and crystal form of methyl ((4-fluoro-5-isobutyl-3-(4-((2-(trifluoromethyl)-1H-imidazol-1-yl)methyl)phenyl)thiophen-2-yl)sulfonyl)carbamate (a compound represented by formula (I)) and use thereof in pharmaceutics.

The invention discloses an anti-tumor 1, 2, 3-triazole-alpha-L-threose nucleoside phosphonate compound as well as a preparation method and application thereof, and the 1, 2, 3-triazole-alpha-L-threose nucleoside phosphonate analogue has a chemical structure as shown in a general formula 1, r1 is phenyl, 2-methylphenyl, 3-methylphenyl, 4-ethylphenyl, 4-propylphenyl, 2-chlorphenyl, 3-chlorphenyl, 4-chlorphenyl, 4-bromophenyl, 3-fluorophenyl, 3-nitrophenyl, 4-methoxyphenyl, 4-cyanophenyl, 3, 4-dichlorophenyl, 3, 4-dichlorophenyl, 3, 4-dichlorophenyl, 3, 4-dichlorophenyl, 3, 4-dichlorophenyl, 3, 4-dichlorophenyl, 3, 4-dichlorophenyl, 3, 4-dichlorophenyl, 3, 4-dichlorophenyl, 3, 4-dichlorophenyl, 3, 4-dichlorophenyl R1, R2, R3, R4, R5, R6, R7, R7, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8, the technical route for preparing the 1, 2, 3-triazole-alpha-L-threose nucleoside phosphonate compound is simple to operate, concise in route and relatively high in yield, the used reagents are common reagents and suitable for large-scale preparation, and in-vitro antitumor activity research finds that the compound has good antitumor activity and can be used for preparing the 1, 2, 3-triazole-alpha-L-threose nucleoside phosphonate compound. The compound is expected to be used as an anti-tumor drug or a primer of the anti-tumor drug.

The invention provides an aggregation-induced emission (AIE) ionic probe (E)-4-(2-(5-(4-(diphenylamino) phenyl) thiophene-2-yl) vinyl)-1-(4-sulfanilamide acyl benzyl) quinoline-1-onium hexafluorophosphoric acid (V) salt of a targeted golf apparatus, namely a fluorescent probe TTQ-GA, a preparation method of the fluorescent probe TTQ-GA and application of the fluorescent probe TTQ-GA in the aspect of detection. The benzenesulfonamide group of the probe can be selectively combined with a Golgi apparatus protein cyclooxygenase 2 (COX-2) inhibitor SC-558 to realize Golgi apparatus targeting; due to the hydrophobic triphenylamine part and the hydrophilic quinoline cation part of the probe, the probe has amphipathy; the probe does not emit fluorescence in an aqueous solution, and can emit strong fluorescence when molecular movement is limited and excited, so that no-wash marking of the Golgi apparatus is realized; the probe generates a large amount of ROS under light excitation, promotes local lipid peroxidation increase of Golgi apparatus, and promotes cancer cell apoptosis.

The present application relates to the technical fields, specifically relates to a kind of synthetic method of lotilana, including, with 3-methyl thiophene as starting material, by eight-step reaction lotilana is prepared, specific steps are as follows: first step: 3-methyl thiophene is made into intermediate 2-chloromethyl-3-methyl thiophene by Blanc chloromethylation reaction;Second step: 2-chloromethyl-3-methyl thiophene is made into intermediate 1-(5-(chloromethyl)-4-methyl thiophene-2-yl) ethanone by Friedel-Crafts acylation reaction with acetyl chloride;Third step: 1-(5-(chloromethyl)-4-methyl thiophene-2-yl) ethanone is made into intermediate 2-hydroxymethyl-3-methyl-5-acetyl thiophene by sodium carbonate hydrolysis;Eighth step: 3-methyl-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3-yl) thiophene-2-yl) methyl cyanide is made into lotilana by Ritter reaction with 2-chloro-N-(2,2,2-trifluoroethyl) acetamide;High atomic economy;Raw material is cheap and easy to obtain;No dangerous process.

The invention relates to a thiophene-modified copper-cluster metal covalent organic framework material and application of the thiophene-modified copper-cluster metal covalent organic framework material in photocatalysis of organic conversion of thioamide into thiadiazole. According to the invention, a cyclic trinuclear copper cluster unit is used as a raw material, and the cyclic trinuclear copper cluster unit, 2, 5-bis (thiophene-2-yl) benzene-1, 4-diamine (alpha SPA) and 2, 5-bis (thiophene-3-yl) benzene-1, 4-diamine (beta SPA) are prepared into two types of thiophene modified copper cluster metal covalent organic framework (M-COF) materials with efficient charge separation efficiency through a solvothermal method. The material is applied to the field of photocatalytic organic conversion, and thioamide cyclization and conversion of derivatives of thioamide are achieved under irradiation of a white light LED. The prepared M-COF has excellent charge separation efficiency and electron mobility, the catalyst is applied to performance research of photocatalytic thioamide cyclization reaction, and the synthesis strategy of the catalyst has wide substrate universality and functional group compatibility. The activity is not obviously attenuated after continuous and repeated recycling, and the efficient and sustainable photocatalytic conversion performance is manifested.

The application discloses a bipolar polymer semiconductor material containing difluoro-substituted indathrene and a preparation method and application thereof. N The copolymerization of the obtained copolymer monomer and 5,5'- (bistrimethyltinyl) -2,2'-dithiophene or (E) -1,2- (5- (bistrimethyltinyl) -thiophene-2-yl) ethylene, a centrosymmetric monomer, through a bromination reaction of bromo-succinimide to obtain a novel bipolar polymer semiconductor material containing difluoro-substituted indathrene with a D-A configuration. The synthesis route of the application is simple and efficient, raw materials are easy to obtain, the cost is low, the universality is high, and the repeatability is good. The material has the advantages of good solubility, excellent thermal stability and strong absorption spectrum range. The bipolar polymer semiconductor material prepared by the application is used as an active layer material, and an organic field effect transistor device prepared by the application has excellent electrical performance. The material has broad commercial prospects in organic thermoelectricity, organic field effect transistors, organic logic complementary circuits and other optoelectronic devices.

The invention discloses a duloxetine hydrochloride key intermediate synthesis method, which comprises: in a hydrogen atmosphere, under the action of a compound represented by a formula V, carrying out an asymmetric catalytic hydrogenation reaction on a compound represented by a formula I to obtain a compound represented by a formula II, the method has the advantages of mild reaction conditions, simple operation, high catalytic efficiency, high yield, high product purity and high ee value, and is very suitable for industrialization.

The invention discloses a D-A type covalent organic framework material as well as a preparation method and application of the D-A type covalent organic framework material. The material is obtained through aldehyde amine condensation by using N, N ', N'-tetra (p-aminophenyl) p-phenylenediamine (TAPB) as a donor unit and 3, 6-bis (5-aldehyde thiophene-2-yl)-2, 5-bis (2-ethylhexyl) pyrrolo [3, 4-c] pyrrolo [3, 4-c] pyrrole-4 (2H, 5H)-diketone (DSZ) as an acceptor unit, and the material is of a two-dimensional layered porous structure, is dark blue and has reversible switching electrochromic performance from dark blue to nearly transparent color. According to the invention, a donor-receptor type covalent organic framework structure is constructed through TAPB and DSZ, and reversible color change from dark blue to nearly colorless in a near-infrared region is realized by using synergistic oxidation reduction of a D-A unit and charge transfer characteristics of a conjugated framework.

The invention relates to the field of organic synthesis, and relates to a preparation method of a novel N-polyfluoroalkylamine compound, the compound is represented by a formula I. A is selected from P or S, R1 is selected from any one of F, Cl, N, alkyl, phenyl, alkoxy, alkylthio, phenoxyl, thiophenyl or amido, R2 is selected from any one of F, Cl, N, alkyl, phenyl, alkoxy, alkylthio, phenoxyl, thiophenyl and amido, and R3 is selected from any one of F, Cl, N, alkyl, phenyl, alkyl, alkyl, alkyl, phenyl, alkoxy, alkylthio, phenoxyl, thiophenyl and amido. R < 2 > is selected from any one of O, N, alkyl, phenyl, alkoxy, alkylthio, phenoxyl, thiophenyl or amido, R < 3 > is selected from any one of alkyl, alkenyl, phenyl, naphthyl, ester group, pyridyl, thienyl, indolyl, furyl or pyrrolyl, R < 4 > is CFxH (3-x) or CF2R < 5 >, R < 5 > is selected from one of CF3 or phenoxyl, and x is 2 or 3; according to the invention, a compound containing active fluorine is introduced to a nitrogen atom, so that the metabolic stability and the radioactive labeling capability are improved, and a brand new way is opened up for designing more intelligent drugs and probes.

Radiolabeled compounds and methods of use thereof of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: R1 is a C1-C6 alkyl; R2 is H, a C1-C6 alkyl, or a C1-C6 haloalkyl; or R1 and R2 together form a 5- or 6-membered cycloalkyl ring, a substituted or unsubstituted thiophenyl, or a substituted or unsubstituted phenyl; R3 is H, a C1-C6 alkyl, a C1-C6 haloalkyl, a C1-C6 hydroxyl alkyl, a C3-C6 cycloalkyl, a C1-C6 alkylnitrile, or an C1-C6 alkylcycloalkyl; R4 is alkyl or haloalkyl; R5 is H or halide; and L is a 2 to 10 carbon linking group; provided that: when R1 is Me, R2 is Me, R3 is H, R4 is —OCH2CF3, and L is —CH2—CH2—CH2—, R5 is not H; and when R1 is Me, R2 is H, R3 is H, R4 is —OCH2CF3, and L is —CH2—CH2—CH2—, R5 is not H.

The present disclosure relates to an oligomeric bio-based surfactant, a preparation method and application thereof, the oligomeric bio-based surfactant has the structure shown in formula 1 or formula 2: X1-X2 is selected from -(CH2) n Or a substituted or unsubstituted thiophene group with 4-10 carbon atoms, n represents the number of CH2, and n is selected from any integer from 0 to 12; Z1-Z5 are each independently selected from a disaccharide group, R1-R5 are each independently selected from -CH(CH3)-Y-COOH, wherein Y is selected from a saturated or unsaturated linear alkyl group with 9-19 carbon atoms. Compared with unmodified sophorolipids, the oligomeric bio-based surfactant of the present disclosure has a lower contact angle and higher wettability; at the same time, the molecule has a branched space structure and intramolecular sugar ring steric hindrance, which can promote the fusion between bubbles, exhibit low foam characteristics, and has good industrial application prospects as a green and efficient low-foaming bio-based cleaning agent.

The invention relates to an azobenzene quenching unit and a preparation method thereof, a solid-phase synthesis carrier and a preparation method thereof, and a nucleic acid probe. The azobenzene quenching unit has a structural general formula as follows: in the formula, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and R13 are independently hydrogen, methyl, ethyl, propyl, isopropyl, phenyl, biphenyl, 2-furyl, 2-thienyl, methoxyl, ethyoxyl, isopropoxy, nitro, nitroso or cyano, n is equal to 0-6, and m is equal to 2-12. The azobenzene quenching unit contains a polyfluorocarboxylic acid connecting structure, the azobenzene quenching unit and amino on the surface of a solid-phase synthesis carrier form an amido bond through carboxylic acid of the polyfluorocarboxylic acid connecting structure, and the azobenzene quenching unit is connected to the solid-phase synthesis carrier and used for synthesizing nucleic acid. The synthesis yield of the 3 '-azobenzene quenching agent labeled nucleic acid can be effectively improved.

The application discloses a kind of thiophene-based ionic liquid modified graphene heat-conducting fillers and heat-conducting composite materials based thereon, the heat-conducting filler is with benzothiophene as raw material and is synthesized 2-methylbenzothiophene by substitution, then with methyl iodide reaction generates thiophene-based ionic liquid, again and electric stripping graphene is modified after blending and obtains filler, it is made into skeleton by ice template method, and vacuum infiltration polydimethylsiloxane process is used, and heat-conducting composite material is prepared.The cation-π and π-π synergistic effect between the thiophene-based ionic liquid synthesized in the application and the filler graphene improves the dispersibility between the fillers and enhances the heat transfer performance between the graphene, thereby significantly improving the heat-conducting performance of the PDMS-based polymer composite material under low filler content.

The invention discloses an N-(3 / 4-((6-substituted pyrimidine-4-yl) amino) phenyl) amide derivative and application thereof, and belongs to the field of medical chemistry. The structural formula of the compound is as follows: R1 is 4-methyl-1H-imidazole-1-group, 3-methyl-1H-pyrazole-1-group or 4-methyl-1H-pyrazole-1-group, R2 is 4-methyl-1H-imidazole-1-group, and R3 is 3-methyl-1H-pyrazole-1-group; r2 is a linear alkyl group, a cycloalkyl group, a 1-methylpiperidine-4-group, a morpholinyl ethyl group, a substituted or unsubstituted phenyl group, a substituted or unsubstituted styryl group, a substituted or unsubstituted phenethyl group, a phenylpropyl group, a phenylbutenyl group, a 6-bromo-pyridine-2-group, a (benzo [d] [1, 3] dioxol-5-group) vinyl group or a (thiophene-2-group) methyl group. The invention relates to a novel Nur77 targeted giant vesicle type death inducer which is suitable for single-drug treatment of lung cancer or is combined with other targeted / immune / chemotherapeutic drugs to improve the curative effect and reduce the drug resistance risk. And the Nur77 can be expanded to breast cancer, liver cancer and other Nur77 related tumors.

The present application provides a kind of derivative of dual-target inhibitor structure, the compound has the structure of formula (I) as shown in formula (I): formula (I) wherein, in formula (I) R1 It is selected from phenyl, 2-fluorophenyl, 3-fluorophenyl, 4-fluorophenyl, 4-chlorophenyl, 4-bromophenyl, 4-trifluoromethylphenyl, 4-methylphenyl, 4-ethylphenyl, 4-isopropylphenyl, 4-methoxyphenyl, 4-nitrophenyl, 4-methylsulfonylphenyl, thienyl, pyridyl, 3,5-difluorophenyl, 3,5-dichlorophenyl, 3,4,5-trifluorophenyl;R2 It is selected from H, halogen, trifluoromethyl, R2 It is in arbitrary position substitution position, single substitution or multiple substitution.The present application uses the derivative of the dual-target inhibitor structure for the use of the agent for preventing and treating plant pathogenic fungi.It can be seen that it has inhibitory effect on various plant fungi, and the inhibitory effect in sclerotinia is more significant.It has significant inhibitory effect on succinate dehydrogenase and chitin synthase activity.

This invention discloses a thiophene ring-rich covalent organic framework material, its preparation method, and its applications, belonging to the field of semiconductor photocatalytic materials technology. Using 1,3,5-tris[2-cyano-2-(4-aminophenyl)vinyl]benzene as the amine monomer and 2,5-di(thiophene-2-yl)terephthalaldehyde as the aldehyde monomer, a thiophene ring-rich LTP-COF material is prepared via a solvothermal reaction. This material forms a large-size conjugated system and abundant thiophene ring active sites, exhibiting strong visible light absorption, high photogenerated carrier separation and transport efficiency, and a photocatalytic hydrogen peroxide production rate in water reaching up to 4805 μmol / g. ‑ 1 h ‑1 The process conditions of this invention are mild, environmentally friendly, low-cost, and easy to scale up. The resulting material exhibits excellent catalytic activity, selectivity, and stability, significantly superior to existing covalent organic framework photocatalysts, and has significant application value in the field of photocatalytic green preparation of hydrogen peroxide.

A diaryloxybenzoxadiazole compound having the general formula (Ia) and disubstituted with a thiophene group, wherein: -Z represents a sulfur atom, an oxygen atom, or a selenium atom; or an NR5 group, wherein R5 is selected from straight-chain or branched C1-C groups. 20 Preferably C1-C8 alkyl, or selected from optionally substituted aryl groups; -R1, R2, and R3, which may be the same or different from each other, representing hydrogen atoms; or selected from straight-chain or branched C1-C groups optionally containing heteroatoms. 20 Preferably C1-C8 alkyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted straight-chain or branched C1-C 20 Preferably, it contains C1-C8 alkoxy groups and -COOR6 groups, wherein R6 is selected from straight-chain or branched C1-C6 groups. 20 The preferred alkyl group is C1-C8, or cyano; R1 and R2 may optionally be combined to form a saturated, unsaturated, or aromatic cyclic or polycyclic system containing 3 to 14 carbon atoms, preferably 4 to 6 carbon atoms, together with the carbon atoms to which they are bonded, which optionally contains one or more heteroatoms, such as, for example, oxygen, sulfur, nitrogen, silicon, phosphorus, selenium; R4 may be the same as or different from each other, selected from optionally substituted aryl groups. The diaryloxybenzoxadiazole compound having the general formula (Ia) and disubstituted with a thienophene group can be advantageously used as a spectral converter in a light-emitting solar concentrator (LSC), which in turn can improve the performance of a photovoltaic device (or solar device) on a rigid or flexible support, for example, a selection between photovoltaic cells (or solar cells) and photovoltaic modules (or solar modules). More specifically, the photovoltaic device (or solar device) can be advantageously used to construct a greenhouse.

The present invention relates to a method for preventing or treating cancer and its use therefor. The method or use may include administering a cancer therapy together with a compound of Formula (I). In the compound of Formula (I), A is a substituted heteroaryl containing at least one ring nitrogen, and D includes optionally substituted phenyl, N-linked 3,4-dihydro-2H-benzo[b][1,4]oxazinyl, N-linked 10H-phenoxazinyl, indole, pyridinyl, pyrimidinyl, pyrazolo[1,5-a]pyridinyl, or thienyl (or R3' and D together form a 5- or 6-membered ring). The compound of Formula (I) may be an inhibitor of transient receptor potential vanilloid 6 (TRPV6). The cancer therapy may be a chemotherapeutic agent. The present invention also relates to pharmaceutical compositions and kits containing the compound of Formula (I) and / or a chemotherapeutic agent. TIFF2026502807000127.tif30170

The invention discloses a pyrazolone compound as well as a preparation method and application thereof. The compound has a structural formula as shown in a formula I, wherein X is selected from N or O; r1 is selected from thienyl, naphthyl, phenyl or phenyl substituted by at least one of C1-6 alkyl, C1-6 alkoxy and halogen; r2 is selected from alkyl of C1-6, phenyl or phenyl substituted by alkoxy of C1-6; r3 is selected from H and alkyl of C1-6; and R4 is selected from phenyl or phenyl substituted by at least one of C1-6 alkyl, C1-6 alkoxy and halogen. The invention provides a series of pyrazolone compounds with novel structures, and the compounds can protect nematodes and reduce damage of formaldehyde to the nematodes, so that the survival rate of the nematodes is improved. The compound can be used for preparing medicines for treating and / or preventing Parkinson's disease, senile dementia or formaldehyde poisoning.

The application relates to an azobenzene quencher unit, a preparation method thereof, a solid-phase synthesis carrier, a preparation method thereof, and a nucleic acid probe. The structural general formula of the azobenzene quencher unit is shown in the following formula: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and R13 are independently hydrogen, methyl, ethyl, propyl, isopropyl, phenyl, biphenyl, 2-furyl, 2-thienyl, methoxy, ethoxy, isopropoxy, nitro, nitroso or cyano, n=0-6, and m=2-12. The azobenzene quencher unit contains a polyfluorocarboxylic acid connecting structure. The azobenzene quencher unit is connected to the solid-phase synthesis carrier through the formation of an amide bond between the carboxylic acid of the polyfluorocarboxylic acid connecting structure and the amino group on the surface of the solid-phase synthesis carrier, and is used for synthesizing nucleic acids. The synthesis yield of 3' azobenzene quencher-labeled nucleic acids can be effectively improved.