A thiophene-substituted aza-fluoroboron dipyrrole compound, nanoparticles of the compound, and their preparation method and application

By synthesizing thiophene-substituted azafluoroborane dipyrrole compounds and preparing their nanoparticles, the problem of large drug side effects in existing obesity treatment plans was solved, and selective targeting of adipose tissue and photothermal treatment effects were achieved.

CN119874742BActive Publication Date: 2025-09-23ANHUI UNIV
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Patent Information

Application Number
CN202510064797.X
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-01-15
Publication Date
2025-09-23
Estimated Expiration
2045-01-15

AI Technical Summary

Technical Problem

Existing obesity treatment options have the problem of serious off-target side effects caused by long-term drug use, and lack effective targeted treatment strategies, especially insufficient selective intervention of white adipose tissue.

Method used

Thiophene-substituted nitrogen-fluoroborane dipyrrole compounds were designed and synthesized, and their nanoparticles were prepared by nanoprecipitation method. Photothermal therapy was performed using 808nm laser to achieve targeted distribution and temperature regulation of adipose tissue.

Benefits of technology

It achieves selective targeting of adipose tissue, has good biocompatibility and photothermal conversion efficiency, and can achieve precise control of temperature by adjusting laser power and concentration, and is used for photothermal treatment of obesity.

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Abstract

The present invention discloses a thiophene-substituted aza-fluoro-boron-dipyrrole compound, nanoparticles of the compound, and their preparation methods and applications. The thiophene-substituted aza-fluoro-boron-dipyrrole compound designed and synthesized by the present invention, the introduction of the thiophene group can significantly red-shift the absorption spectrum of aza-fluoro-boron-dipyrrole, successfully red-shifting to the 810nm near-infrared region, which is more conducive to its application in vivo and in photothermal therapy. Nanoparticles prepared with this compound as the core can be effectively distributed to visceral adipose tissue after local intraperitoneal administration, selectively targeting visceral adipose tissue, have good biocompatibility and high photothermal conversion efficiency, can achieve temperature regulation by adjusting its concentration and 808nm laser power, and can be used for photothermal treatment of obesity.
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