Taspine alkaline preparation method and uses in preparing medicine for treating tumour

A technology of tospinine and alkali solution, which is applied in antineoplastic drugs, drug combinations, active ingredients of heterocyclic compounds, etc., can solve problems such as no application reports of tospinine, and achieve high product purity and simple process steps Effect

Inactive Publication Date: 2006-07-12
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] So far, no report on the angiogenesis-inhibiting effect of tuspinine and its application in the preparation of drugs for the treatment of tumors has been found.

Method used

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  • Taspine alkaline preparation method and uses in preparing medicine for treating tumour
  • Taspine alkaline preparation method and uses in preparing medicine for treating tumour

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Taking the used raw material orchids total alkaloids 100g of preparing tospin base as an example, its preparation method steps are as follows:

[0050] 1. Configure the solution

[0051] Prepare 1000 g of hydrochloric acid solution with a concentration of 1% in a conventional method as a solution.

[0052] 2. Dissolving total alkaloids of red hair seven

[0053] Get the total alkaloids 100g of orchids and put them into the reaction kettle, add the concentration of 1% hydrochloric acid solution 1000g, stir with a mixer to make it fully dissolve, and make the total alkaloids of orchids solution.

[0054] 3. Adsorption separation

[0055] Pack the LSD001 type cation exchange resin of 100g on the total alkaloid solution of the red hair seven prepared in step 2 into a column, the column diameter and the column height ratio are 1: 3, the adsorption flow rate is 1.2 times column volume per hour, and the adsorption is carried out at normal temperature and pressure separate. ...

Embodiment 2

[0066] Taking the used raw material orchids total alkaloids 100g of preparing tospin base as an example, its preparation method steps are as follows:

[0067] In this embodiment, in the process step of preparing the dissolving solution, 1000 g of hydrochloric acid solution with a concentration of 2% was prepared as the dissolving solution according to the conventional method. In the process step of dissolving the total alkaloids of orchids, take 100 g of the total alkaloids of orchids and put them into the reactor, add 1000 g of hydrochloric acid solution with a concentration of 2%, stir it with a mixer to fully dissolve it, and make the total alkaloids of orthys anesthesia solution . In the adsorption separation process step, the adsorption flow rate is 1.1 times the column volume per hour, and the adsorption separation is carried out at normal temperature and pressure. Other processing steps are identical with embodiment 1.

Embodiment 3

[0069] Taking the used raw material orchids total alkaloids 100g of preparing tospin base as an example, its preparation method steps are as follows:

[0070] In this embodiment, in the process step of preparing the dissolving solution, 1200 g of hydrochloric acid solution with a concentration of 0.5% was prepared according to the conventional method as the dissolving solution. In the process step of dissolving the total alkaloids of orchids, take 100 g of the total alkaloids of orchids and put them into the reactor, add 1200 g of hydrochloric acid solution with a concentration of 0.5%, stir it with a mixer to fully dissolve it, and make the total alkaloids of orthys anesthesia solution . In the adsorption separation process step, the adsorption flow rate is 1.0 times the column volume per hour, and the adsorption separation is carried out at normal temperature and pressure. Other processing steps are identical with embodiment 1.

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Abstract

The invention relates to a method for preparing for taspine alkali and the applied in preparing for the drug to treat tumor. The preparing method comprises: preparing for dissolving solution, dissolving the cohosh root base, adsorption stripping, preparing for eluent, cleaning, and concave condensation, recrystallizing and checking. The 222 test result expresses that it has the effect of depressing blood vessel formation.

Description

technical field [0001] The invention belongs to the technical field of preparation methods of pharmaceutical compounds, and in particular relates to a preparation method of tospinine with angiogenesis-inhibiting and anti-tumor effects and the application of the active ingredient in the preparation of drugs for treating tumors. Background technique [0002] Radix et Rhizoma Leonticis (Radix et Rhizoma Leonticis) is the root and rhizome of Leonticerobustum (Maxim.) Diels., a plant of the family Berberidaceae. It is produced in the Qinling Mountains and Daba Mountains. It is also distributed in the former Soviet Union and Japan. It is a natural medicine that is not included in the Pharmacopoeia. Contains alkaloids such as Magnoline, Taspinine, N-methylcytisine, D-lupine. [0003] Taspine (1-[2-(Dimethylamino)ethyl]-3,8-dimethoxy[1]benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione, Taspine) is a Aporphylloid alkaloids, containing two lactone ring structures, the molecular formula ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/06A61P35/00A61K31/35
Inventor 贺浪冲李义平卢闻张彦民张健何强杜娟吴娇芬
Owner XI AN JIAOTONG UNIV
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