Use of ammidin in preparing medicine for treating cadiac and cerebral vasular diseases

A kind of technology of cardiovascular and cerebrovascular diseases, imperatorin, applied in the field of compound pharmacological action

Inactive Publication Date: 2007-06-06
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Imeratorin is the main active ingredient of coumarins in Angelica dahurica, so far, there is no report on the direct effect of imperatorin on resistance blood vessels

Method used

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  • Use of ammidin in preparing medicine for treating cadiac and cerebral vasular diseases
  • Use of ammidin in preparing medicine for treating cadiac and cerebral vasular diseases
  • Use of ammidin in preparing medicine for treating cadiac and cerebral vasular diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0022] 1. Relaxation effect of imperatorin on rat abdominal aorta

[0023] 1. Instruments and materials

[0024] Powerlab data recording and analysis system, including software Chart 5.0 and hardware 8-channel bridge amplifier, AD Instruments Co, Australia; FTO3C tension transducer (Grass Instrument Co. Quincy, Mass, U.S.A); Myograph Constant temperature organ bath (DMT, Denmark); SHB-3 circulating water multipurpose vacuum pump (Zhengzhou Dupu Instrument Factory); XTZ-E type continuous zoom stereo microscope (Shanghai Optical Instrument Factory); pHs-3C precision pH agent (Shanghai Precision Scientific Instrument Co., Ltd.); MP200B electro-optical analytical balance (Shanghai Liangping Instrument Co., Ltd.); oxygen supply device; ophthalmic surgical instruments; 100μL micro-sampler (Shanghai Gaoxin Glass Instrument Factory); small syringe.

[0025] Glucose, sodium chloride, potassium chloride, disodium edetate, potassium dihydrogen phosphate (A.R., Xi'an Chemical Reagent Fac...

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Abstract

The present invention discloses the use of ammidin in preparing medicine for treating cardiac and cerebral vascular diseases. Experiments shows that ammidin has obvious blood vessel relaxing effect, and can relax KCl and ET-1 pre-retracted rat arteria mesenterica and NA and U46619 pre-retracted human caul artery. Ammidin relaxes blood vessel without dependent on endothelial cell. Ammidin relaxes blood vessel mainly by means of inhibiting the outer calcium inflow and the inner calcium release mediated by the voltage depending calcium channel and acceptor calcium channel and slightly depending on KCa channel. Ammidin may be used in preparing medicine for treating cardiac and cerebral vascular diseases.

Description

technical field [0001] The invention belongs to the technical field of pharmacological action of compounds, and in particular relates to the application of imperatorin in the preparation of anti-cardiovascular and cerebrovascular diseases. Background technique [0002] Modern pharmacology studies the pharmacological effects of active ingredients usually use two types of models, one is the whole animal model, and the other is the isolated organ model. The former is mainly used for pharmacodynamic observation, and the latter is mainly used to explore the mechanism of drug action. [0003] The isolated organ model has been used for more than a hundred years, and it is still an important and convenient method in pharmacological research. By observing the effect of active ingredients on specific isolated tissues and organs, the mechanism of action and possible pharmacological effects of active ingredients can be analyzed. Selecting different samples can d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/366A61P9/00
Inventor 贺浪冲贺建宇赵洁曹永孝王嗣岑杨广德李西玲王红英刘静
Owner XI AN JIAOTONG UNIV
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