Preparation method and application of inonotus obliquus polysaccharide

A technology of Inonotus obliquus and polysaccharide is applied in the field of preparation of Inonotus obliquus polysaccharide, which can solve problems such as unclear action mechanism, and achieve the effects of excellent antioxidant capacity, inhibition of aging and apoptosis, and broad application prospects.
CN109748982AActive Publication Date: 2019-05-14JINLIN MEDICAL COLLEGE
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
JINLIN MEDICAL COLLEGE
Publication Date
2019-05-14

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Abstract

The invention discloses a preparation method and application of inonotus obliquus polysaccharide. Through water extraction and alcohol precipitation, repeated freeze thawing, deproteinization, dialysis, freeze drying, affinity chromatography and other methods, a polysaccharide component with antioxidant and anti-aging functions is separated and purified from inonotus obliquus; the inonotus obliquus polysaccharide component has strong antioxidant activity; through pretreatment of the inonotus obliquus polysaccharide, etoposide-induced proliferation inhibition and apoptosis of rat aortic smoothmuscle cells can be inhibited, and etoposide-induced cellular senescence beta-galactosidase activity increase, senescence-related heterochromatin aggregation and mitochondrial membrane potential decline can be inhibited; through pretreatment of the inonotus obliquus polysaccharide, etoposide-induced increase in expression levels of p53, p21 and p16 protein and mRNA can be inhibited. The inonotus obliquus polysaccharide components prepared according to the preparation method provided by the invention has good antioxidant and anti-aging activity and has a broad application prospect as a novel anti-aging protective medicine.
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Description

technical field

[0001] The invention relates to the field of natural product active ingredients, and more specifically relates to a preparation method and application of Inonotus obliquus polysaccharide. Background technique

[0002] Inonotus obliquus (Fr.) Pilt is a rare and valuable medicinal fungus. , P. brown, P. obliquus, P. obliquus, Rosa, and Ganoderma lucidum, in the biological category, belong to the fungal phylum, basidiomycotina, laminomycetes, nonbryomycetes, polyporaceae , Brown Poria genus, mostly parasitic under the bark of birch, silver birch, elm, alder, etc. or on the dry after felling, mainly distributed in the area of ​​​​45°-50° north latitude.

[0003] As early as the 12th century, the Manchu people used Inonotus obliquus to treat diseases. It is said that the Manchu people relied on Inonotus obliquus to treat various diseases when the mountains were closed by heavy snow. Over the years, Inonotus obliquus has been used in many countries to resist disea...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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