Selective androgen receptor modulators and methods of use thereof

An androgen receptor, selective technology, applied in the direction of plant growth regulators, botany equipment and methods, applications, etc., can solve the problem of non-steroidal androgen reports and other issues
CN1471508AInactive Publication Date: 2004-01-28UNIV OF TENNESSEE RES FOUND
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
UNIV OF TENNESSEE RES FOUND
Publication Date
2004-01-28
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention provides a novel class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds which are tissue-selective androgen receptor modulators (SARM), which are useful for oral testosterone replacement therapy, male contraception, maintaining sexual desire in women, treating prostate cancer and imaging prostate cancer. These agents have an unexpected in-vivo activity for an androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. These agents may be active alone or in combination with progestins or estrogens. The invention further provides a novel class of nonsteroidal agonist compounds and methods of binding an androgen receptor, modulating spermatogenesis, treating and imaging prostate cancer, and providing hormonal therapy for androgen-dependent conditions.
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Description

technical field

[0001] The present invention relates to a new class of tissue selective androgen receptor targeting agents (ARTAs) which exhibit androgenic and anabolic activity of non-steroidal ligands of the androgen receptor. Targeted Agents Definition Those are a new subclass of compounds that are Tissue Selective Androgen Receptor Modulators (SARMs) that are useful in androgen therapies such as oral testosterone replacement therapy, male contraception, maintenance of libido in women, treatment of prostate cancer and imaging of prostate cancer it works. These agents are also administered to subjects for the treatment of sarcopenia, loss of libido, osteoporosis, erythropoiesis, and fertility. Targeting agents can be used alone or in combination with progesterone or estrogen. Background technique

[0002] The androgen receptor ("AR") is a ligand-activated transcriptional regulatory protein that mediates male sexual development and function through its endogenous androgen...

Claims

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