A method of treating breast cancer with androgen receptor antagonists
An androgen receptor, antagonist technology, applied in the field of prevention and treatment of individuals, can solve the problems of ineffectiveness, danger and high cost
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Embodiment 1
[0250] Extended cytotoxicity studies of compounds in different cell lines
[0251] Different prostate cancer cell lines (DU145, PC-3, TSU, PPC-1 and LNCaP), breast cancer cell line (MCF-7), other cancer cell lines (MCF- 7) and the control cell line (CV-1), the IC of I-31, I-29, S-NTBA and Compound V 50 As shown in Table 2A and B.
[0252] Table 2A - Prostate cancer cell lines
[0253]
[0254] Table 2B - Other cancer cell lines and controls
[0255]
Embodiment 2
[0257] Effects of Compounds on Apoptosis in Different Cell Lines
[0258] Determination of I-31, I-29, S-NTBA and compound V in different prostate cancer cell lines (DU145, PC-3, TSU, PPC-1 and LNCaP), breast cancer cell line (MCF-7) and other cancer cell lines (TCCSUP, HT-29) and the ability to induce apoptosis in the control cell line (CV-1), the results are shown in Table 3.
[0259] table 3
[0260] Apoptosis by Histone assay
[0261]
Embodiment 3
[0263] Sensitivity of Androgen Receptor Responsive Cells to Compound V
[0264] The relative androgen receptor (AR) expression of various cell lines is shown in Table 4. Both the LNCaP prostate and MCF-7 breast cancer cell lines express androgen receptors, whereas the prostate cancer cell lines PC-3 and Du145 and the African green monkey kidney epithelial CV-1 cells do not express androgen receptors (Chlenski, MacIndoe, Warriar , Webber 1 & 2).
[0265] cell line
LNCaP
PC-3
Du 145
MCF-7
CV-1
AR
+
-
-
+
-
+
N / A
N / A
-
N / A
T877A
N / A
N / A
N / A
N / A
Methylation of the AR promoter
-
powerful
completely
-
N / A
transcription
normal
-
-
normal
-
PSA expression
+
-
-
+
-
Other steroid receptors:
EGF / TGF-α
FGF...
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