Metabolites of selective androgen receptor modulators and methods of use thereof

A technology of androgen receptors and metabolites, applied in the field of selective androgen receptor modulators, which can solve problems such as harm to individual health, increased susceptibility to infection, and susceptibility to damage
CN1972682AInactive Publication Date: 2007-05-30UNIV OF TENNESSEE RES FOUND
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
UNIV OF TENNESSEE RES FOUND
Publication Date
2007-05-30
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention provides metabolites of a class of androgen receptor targeting agents (ARTA). The SARM compounds and their metabolites, either alone or as a composition, are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia, osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition, and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and / or prevention of acute and / or chronic muscular wasting conditions; e) preventing and / or treating dry eye conditions; f) oral androgen replacement therapy; g) decreasing the incidence of, halting or causing a regression of prostate cancer; and / or h) inducing apoptosis in a cancer cell.
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Description

field of invention

[0001] The present invention relates to a new class of metabolites of androgen receptor targeting active agents (ARTAs) which are selective androgen receptor modulators (SARMs). Said SARM compounds and their metabolites are useful in a) male contraception; b) in the treatment of various hormone-related disorders, such as those associated with decreased androgen in aging males (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction , erectile dysfunction, hypogonadism, osteoporosis, alopecia, anemia, obesity, sarcopenia, osteopenia, osteoporosis, benign prostatic hyperplasia, mood and cognitive changes, and prostate cancer; c) treatment with female androgen Reduced (ADIF)-related conditions such as sexual dysfunction, decreased libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, cognitive and mood changes, depression, anemia, hair loss, obesity, endometriosis d) treatment and / or prevention of acute and / or chronic muscle wasting; e) ...

Claims

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