Photo-initiated drug balloon catheter

Abstract

The invention relates to the technical field of medical instruments, in particular to a photo-initiation medicine balloon catheter which comprises a catheter body, a balloon fixedly arranged at the far end of the catheter body, a catheter base fixedly arranged at the near end of the catheter body and a plurality of micro spraying pipes fixedly arranged on the outer surface of the balloon. Wherein the catheter main body comprises a first catheter, and a second catheter which is fixedly arranged outside the first catheter in a sleeving manner; wherein a first pipe cavity is formed between the inner wall of the second guide pipe and the outer wall of the first guide pipe, and a plurality of second pipe cavities are arranged between the outer wall of the second guide pipe and the inner wall of the second guide pipe in an annular array mode with the axis of the second guide pipe as the reference; through local administration, the photosensitizer is efficiently activated, the side effects of the whole body are reduced, the treatment effect on diseases such as bile duct cancer is improved, the medical cost is reduced, and the living quality of a patient is also improved.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a light-triggered drug balloon catheter. Background Art

[0002] Currently, surgical resection is the first choice for the treatment of cholangiocarcinoma, but most patients have atypical early clinical manifestations, and have extensive invasion or distant metastasis when diagnosed, making surgical resection impossible and leading to poor long-term prognosis. Endoscopic photodynamic therapy is the intravenous injection of photosensitizers that are highly selective and aggregative to tumor cells. They are activated by light irradiation of a specific wavelength and interact with ground-state oxygen molecules to produce reactive oxygen molecules, which induce tumor cell apoptosis and necrosis, occlude the vasculature of tumor tissue, and induce anti-tumor immune response, thereby killing the tumor. Endoscopic photodynamic therapy combined with stent placement can significantly improve the survival rate of patients with unresectable extrahepatic cholangiocarcinoma and ampullary carcinoma.

[0003] However, the current technology of intravenous injection of photosensitizers still has certain defects: intravenous injection of photosensitizers can cause macules and swelling in exposed skin areas, and in severe cases, erosion, exudation, blisters, etc., which will leave pigmentation. Therefore, patients should strictly avoid light for more than 6 months after endoscopic photodynamic therapy. Long-term light avoidance will prevent patients from contacting the outside world, and serious complications such as loneliness, anxiety, and self-image disorder may occur, which seriously limits the application of photodynamic therapy in the treatment of cholangiocarcinoma. In this regard, there is an urgent need for a light-triggered drug balloon catheter that can be placed in the bile duct lesion under endoscopy, so that the bile duct cancer cells and photosensitizers can be locally contacted and absorbed, avoiding skin damage caused by intravenous systemic injection of photosensitizers; patients do not need to avoid light after surgery and can live a normal life, avoiding psychological abnormalities caused by long-term light avoidance. Summary of the invention

[0004] The purpose of the present invention is to provide a light-triggered drug balloon catheter in view of the deficiencies in the prior art;

[0005] To achieve the above object, the technical solution adopted by the present invention is:

[0006] The present invention provides a light-triggered drug balloon catheter, comprising: a catheter body, a balloon fixedly arranged at the distal end of the catheter body, a catheter seat fixedly arranged at the proximal end of the catheter body, and a plurality of micro-spraying tubes fixedly arranged on the outer surface of the balloon;

[0007] Wherein, the catheter body comprises: a first catheter, and a second catheter fixedly arranged on the outside of the first catheter;

[0008] There is a first lumen between the inner wall of the second catheter and the outer wall of the first catheter, and a plurality of second lumens are arranged in a circular array between the outer wall of the second catheter and the inner wall of the second catheter with the axis of the second catheter as a reference;

[0009] The proximal end of the balloon is fixedly arranged at the distal end of the second catheter, the distal end of the balloon is fixedly arranged at the distal end of the first catheter, the balloon cavity is connected to the first lumen, and the distal ends of several of the second lumens are respectively connected to several of the micro-spraying tubes;

[0010] Wherein, the catheter seat comprises: a first catheter seat fixedly arranged at the proximal end of the catheter body, a second catheter seat fixedly arranged at one side of the first catheter seat, and a third catheter seat fixedly arranged at the other side of the first catheter seat;

[0011] The distal end of the first catheter seat is connected to the first catheter, the distal end of the second catheter seat is connected to the first lumen, and the distal end of the third catheter seat is connected to a plurality of the second lumens respectively;

[0012] Among them, the first catheter is located on the outer side wall of the balloon and is fixedly provided with a plurality of developing rings and a light source, and the micro-spraying pipe located on the outer surface of the balloon is provided with a plurality of spraying ports.

[0013] Furthermore, the first catheter seat also includes: a light source switch and a light source battery; the light source switch and the light source battery are electrically connected to the light source.

[0014] Furthermore, the outer wall of the balloon and the outer wall of the micro-spray tube are coated with a coating containing the ceprofin drug.

[0015] Furthermore, the light source is a LED-IB composite narrow spectrum light source.

[0016] Furthermore, the balloon is made of a transparent polymer material, and the micro-spray pipe is made of an elastic transparent polymer material.

[0017] Furthermore, the developing ring is made of at least one of platinum-iridium alloy, tungsten, or tantalum.

[0018] Furthermore, a first one-way valve is fixedly disposed in the second catheter seat, and a second one-way valve is fixedly disposed in the third catheter seat.

[0019] Further, it also includes: a drug syringe;

[0020] The distal end of the drug syringe is threadedly connected to the proximal end of the third catheter seat and communicates with the second lumen.

[0021] Further, the drug syringe comprises: a drug storage portion, an outlet channel fixedly arranged on one side of the drug storage portion, and an inlet channel fixedly arranged on the other side of the drug storage portion opposite to the outlet channel;

[0022] Wherein, the medicine storage part has a storage cavity, the storage cavity is communicated with the outlet channel, and the storage cavity is communicated with the inlet channel;

[0023] The distal end of the outlet channel is threadedly connected to the proximal end of the third catheter seat, the end of the inlet channel away from the drug storage part is threadedly connected to a sealing cover, and a third one-way valve is fixedly arranged in the outlet channel.

[0024] Furthermore, the medicine storage part is made of rubber material.

[0025] The present invention adopts the above technical solution, and has the following technical effects compared with the prior art:

[0026] In summary, the present invention avoids systemic side effects by coating the coating containing the cefotaxime drug on the outer wall of the balloon and the outer wall of the micro-spray tube and locally releasing it to the lesion site. The irradiation of the LED-IB composite narrow spectrum light source can more effectively activate the local cefotaxime drug, induce tumor cell apoptosis and necrosis, and enhance the therapeutic effect. The cefotaxime drug can also be evenly sprayed on the outer surface of the balloon through the micro-spray tube to ensure a higher drug concentration in the lesion site and a better therapeutic effect. In this regard, the present invention improves the therapeutic effect of diseases such as bile duct cancer by local drug administration, efficient activation of photosensitizers, and reduction of systemic side effects, reduces medical costs, and improves the quality of life of patients. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 It is a schematic diagram of the shaft side structure of the present invention;

[0028] Figure 2 It is a cross-sectional structural schematic diagram of the present invention;

[0029] Figure 3 It is a schematic diagram of the enlarged structure of region A in the present invention;

[0030] Figure 4 It is a schematic diagram of the enlarged structure of the C region in the present invention;

[0031] Figure 5 It is a schematic diagram of the enlarged structure of region B in the present invention;

[0032] Figure 6 It is a schematic cross-sectional view of the drug injector of the present invention;

[0033] The reference numerals in the accompanying drawings are:

[0034] Catheter body, 1; balloon, 2; catheter seat, 3; micro-spray tube, 4; first catheter, 11; first lumen, 12; second lumen, 13; first catheter seat, 31; second catheter seat, 32; third catheter seat, 33; developing ring, 14; light source, 15; light source switch, 16; drug syringe, 5; drug storage unit, 51; outlet channel, 52; inlet channel, 53; third one-way valve, 54. DETAILED DESCRIPTION

[0035] The specific embodiments of the present invention will be described in detail below.

[0036] Unless otherwise defined, technical or scientific terms used in the claims and the specification shall have the common meanings understood by persons having ordinary skills in the technical field to which the present invention belongs.

[0037] The words "include" or similar words used in the patent application specification and claims of the present invention mean that the items appearing before "include" include the items listed after "include" or their equivalents, and do not exclude other items.

[0038] The numerical values ​​mentioned in the present invention include all numerical values ​​that increase from low to high by one unit, assuming that there are at least two units between any lower value and the higher value. For example, if a component or a physical quantity is said to be from 1 to 100, 10 to 90 is more preferred, and 20 to 80 is the most preferred, it is intended to express that values ​​such as 5 to 95, 14 to 76, 23 to 67, 32 to 58, 41 to 49 are clearly listed in this specification; for values ​​less than 1, 0.0001, 0.001, 0.01 or 0.1 are considered to be more suitable as a unit. The above examples are for illustrative purposes only. In fact, all numerical combinations between the lowest value and the highest value listed are deemed to be clearly listed in this specification in a similar manner.

[0039] Example

[0040] This embodiment provides a light-triggered drug balloon catheter, comprising: a catheter body 1, a balloon 2 fixedly arranged at the distal end of the catheter body 1, a catheter seat 3 fixedly arranged at the proximal end of the catheter body 1, and a plurality of micro-spraying tubes 4 fixedly arranged on the outer surface of the balloon 2;

[0041] The catheter body 1 comprises: a first catheter 11, and a second catheter fixedly arranged on the outside of the first catheter 11;

[0042] A first lumen 12 is provided between the inner wall of the second catheter and the outer wall of the first catheter 11, and a plurality of second lumens 13 are provided in a circular array between the outer wall of the second catheter and the inner wall of the second catheter with the axis of the second catheter as a reference.

[0043] The proximal end of the balloon 2 is fixedly arranged at the distal end of the second catheter, the distal end of the balloon 2 is fixedly arranged at the distal end of the first catheter 11, the balloon cavity of the balloon 2 is connected to the first lumen 12, and the distal ends of the second lumens 13 are respectively connected to the micro-spraying tubes 4;

[0044] The catheter seat 3 includes: a first catheter seat 31 fixedly arranged at the proximal end of the catheter body 1, a second catheter seat 32 fixedly arranged at one side of the first catheter seat 31, and a third catheter seat 33 fixedly arranged at the other side of the first catheter seat 31;

[0045] The distal end of the first catheter seat 31 is connected to the first catheter 11, the distal end of the second catheter seat 32 is connected to the first lumen 12, and the distal end of the third catheter seat 33 is connected to a plurality of the second lumens 13 respectively; a first one-way valve is fixedly disposed in the second catheter seat 32, and a second one-way valve is fixedly disposed in the third catheter seat 33;

[0046] The first catheter 11 is located on the outer side wall of the balloon 2 and is fixedly provided with a plurality of developing rings 14 and a light source 15. The micro-spraying tube 4 located on the outer surface of the balloon 2 is provided with a plurality of spraying ports, which are used to evenly distribute the drug to the target area.

[0047] The first catheter seat 31 further includes: a light source switch 16 and a light source battery; the light source switch 16 and the light source battery are electrically connected to the light source 15, and the light source 15 is a LED-IB composite narrow spectrum light source;

[0048] The outer wall of the balloon 2 and the outer wall of the micro-spray tube 4 are coated with a coating containing the ceprofin drug (photosensitizer), which can achieve local drug release and reduce systemic side effects.

[0049] As a technical optimization solution of the present invention, the balloon 2 is made of a transparent polymer material, and the micro-spray tube 4 is made of an elastic transparent polymer material; the balloon 2 is made of a transparent polymer material to ensure the transmittance of light, and the micro-spray tube 4 is made of an elastic transparent polymer material, which not only ensures the transmittance of light, but also has good flexibility and biocompatibility, thereby reducing damage to the bile duct wall;

[0050] The transparent polymer material used in the balloon 2 is polyurethane, and the elastic transparent polymer material used in the micro-spraying tube 4 is polyurethane.

[0051] As a technical optimization solution of the present invention, the developing ring 14 is made of at least one of platinum-iridium alloy, tungsten, or tantalum, so that the developing ring 14 can clearly display the position of the balloon 2 under X-rays, helping doctors to accurately locate the lesion.

[0052] As a technical optimization solution of the present invention, it also includes: a drug injector 5;

[0053] The distal end of the drug syringe 5 is threadedly connected to the proximal end of the third catheter seat 33 and is communicated with the second lumen 13. The threaded connection is simple and reliable, easy to disassemble and clean, and ensures the convenience of using the drug syringe 5. The drug can be delivered to the second lumen 13 through the drug syringe 5, and then sprayed onto the outer surface of the balloon 2 through a plurality of micro-spraying tubes 4, ensuring that the drug is evenly distributed at the lesion site and improving the treatment effect.

[0054] The drug injector 5 comprises: a drug storage portion 51, an outlet channel 52 fixedly arranged on one side of the drug storage portion 51, and an inlet channel 53 fixedly arranged on the other side of the drug storage portion 51 opposite to the outlet channel 52;

[0055] The medicine storage part 51 has a storage cavity therein, the storage cavity is communicated with the outlet channel 52, and the storage cavity is communicated with the inlet channel 53;

[0056] Among them, the distal end of the outlet channel 52 is threadedly connected to the proximal end of the third catheter seat 33, and the end of the inlet channel 53 away from the drug storage part 51 is threadedly connected to a sealing cover, and a third one-way valve 54 is fixedly arranged in the outlet channel 52. The third one-way valve 54 prevents the drug from flowing back during the delivery process, ensures the one-way flow of the drug, and improves the accuracy of drug release. The drug storage part 51 is made of rubber material and has good elasticity and sealing.

[0057] When in use, the first catheter 11 is slowly sent into the patient's body through the endoscope to send the light-triggered drug balloon catheter. The balloon 2 reaches the predetermined bile duct lesion site under the development of X-rays through the guide wire and the developing ring 14 to ensure that it accurately reaches the lesion area. The balloon 2 is inflated by the second catheter seat 32 and the first lumen 12 to expand the balloon 2. When the balloon 2 expands to fit closely to the bile duct wall, the drug storage part 51 is squeezed to spray the cephalosporin drug solution in the drug storage part 51 evenly onto the outer surface of the balloon 2 through the second lumen 13 and the micro-spraying tube 4. The LED-IB composite narrow spectrum light source 15 is started through the light source switch 16 on the catheter seat 3 to illuminate and activate the cephalosporin drug on the balloon surface. After the drug spraying or smearing is completed, the second catheter seat 32 and the first lumen 12 are gradually deflated to restore the balloon 2 to its original state. Then, the light-triggered drug balloon catheter is slowly withdrawn from the patient's body to complete the process.

[0058] In summary, the present invention avoids systemic side effects by coating the coating containing the cefotaxime drug on the outer wall of the balloon and the outer wall of the micro-spray tube and locally releasing it to the lesion site. The irradiation of the LED-IB composite narrow spectrum light source can more effectively activate the local cefotaxime drug, induce tumor cell apoptosis and necrosis, and enhance the therapeutic effect. The cefotaxime drug can also be evenly sprayed on the outer surface of the balloon through the micro-spray tube to ensure a higher drug concentration in the lesion site and a better therapeutic effect. In this regard, the present invention improves the therapeutic effect of diseases such as bile duct cancer by local drug administration, efficient activation of photosensitizers, and reduction of systemic side effects, reduces medical costs, and improves the quality of life of patients.

[0059] The above description is only a preferred embodiment of the present invention, and does not limit the implementation mode and protection scope of the present invention. For those skilled in the art, it should be aware that all solutions obtained by equivalent substitutions and obvious changes made using the description and illustrations of the present invention should be included in the protection scope of the present invention.

Claims

1. A light-triggered drug balloon catheter, characterized in that: include: A catheter body (1), a balloon (2) fixedly arranged at the distal end of the catheter body (1), a catheter seat (3) fixedly arranged at the proximal end of the catheter body (1), and a plurality of micro-spraying tubes (4) fixedly arranged on the outer surface of the balloon (2); The catheter body (1) comprises: a first catheter (11), and a second catheter fixedly arranged on the outside of the first catheter (11); A first lumen (12) is provided between the inner wall of the second conduit and the outer wall of the first conduit (11), and a plurality of second lumens (13) are provided in a circular array between the outer wall of the second conduit and the inner wall of the second conduit with the axis of the second conduit as a reference; The proximal end of the balloon (2) is fixedly arranged at the distal end of the second catheter, the distal end of the balloon (2) is fixedly arranged at the distal end of the first catheter (11), the balloon cavity of the balloon (2) is connected to the first tube cavity (12), and the distal ends of a plurality of the second tube cavities (13) are respectively connected to a plurality of the micro-spraying tubes (4); The catheter seat (3) comprises: a first catheter seat (31) fixedly arranged at the proximal end of the catheter body (1), a second catheter seat (32) fixedly arranged at one side of the first catheter seat (31), and a third catheter seat (33) fixedly arranged at the other side of the first catheter seat (31); The distal end of the first catheter seat (31) is in communication with the first catheter (11), the distal end of the second catheter seat (32) is in communication with the first lumen (12), and the distal end of the third catheter seat (33) is in communication with a plurality of the second lumen (13); The first conduit (11) is fixedly provided with a plurality of developing rings (14) and a light source (15) on the outer side wall of the interior of the balloon (2), and the micro-spraying tube (4) located on the outer surface of the balloon (2) is provided with a plurality of spraying ports.

2. A light-triggered drug balloon catheter according to claim 1, characterized in that: The first catheter seat (31) further comprises: a light source switch (16) and a light source battery; the light source switch (16) and the light source battery are electrically connected to the light source (15).

3. A light-triggered drug balloon catheter according to claim 1, characterized in that: The outer wall of the balloon (2) and the outer wall of the micro-spraying tube (4) are coated with a coating containing the hiprofen drug.

4. A light-triggered drug balloon catheter according to claim 1, characterized in that: The light source (15) is a LED-IB composite narrow spectrum light source.

5. A light-triggered drug balloon catheter according to claim 1, characterized in that: The balloon (2) is made of a transparent polymer material, and the micro-spraying tube (4) is made of an elastic transparent polymer material.

6. A light-triggered drug balloon catheter according to claim 1, characterized in that: The developing ring (14) is made of at least one of platinum-iridium alloy, tungsten, or tantalum.

7. A light-triggered drug balloon catheter according to claim 1, characterized in that: A first one-way valve is fixedly arranged in the second catheter seat (32), and a second one-way valve is fixedly arranged in the third catheter seat (33).

8. The light-triggered drug balloon catheter according to claim 1, characterized in that: Also includes: Medication syringes (5); The distal end of the drug syringe (5) is threadedly connected to the proximal end of the third catheter seat (33) and is communicated with the second tube cavity (13).

9. A light-triggered drug balloon catheter according to claim 8, characterized in that: The drug injector (5) comprises: a drug storage portion (51), an outlet channel (52) fixedly arranged on one side of the drug storage portion (51), and an inlet channel (53) fixedly arranged on the other side of the drug storage portion (51) opposite to the outlet channel (52); The medicine storage part (51) has a storage cavity therein, the storage cavity is in communication with the outlet channel (52), and the storage cavity is in communication with the inlet channel (53); The distal end of the outlet channel (52) is threadedly connected to the proximal end of the third catheter seat (33), the end of the inlet channel (53) away from the drug storage part (51) is threadedly connected to a sealing cover, and a third one-way valve (54) is fixedly arranged in the outlet channel (52).

10. A light-triggered drug balloon catheter according to claim 9, characterized in that: The medicine storage part (51) is made of rubber material.

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