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34 results about "Aging male" patented technology
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The Aging Process in Men. The first aspect of aging in men is the health. Namely, as men get older, their physical and mental functions gradually decrease. Excessive weight gets accumulated around the belly and waist area when men reach their middle age.
Formulations comprising selective androgen receptor modulators
InactiveUS6838484B2Decreased libidoAlteration in mood and cognitionBiocideOrganic chemistryDiseaseAging male
The present invention relates to pharmaceutical compositions and formulations comprising a novel class of androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. The agents define a new subclass of compounds which are selective androgen receptor modulators (SARM) which are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia,osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and / or prevention of chronic muscular wasting; and / or e) decreasing the incidence of, halting or causing a regression of prostate cancer. The present invention provides pharmaceutical compositions comprising the selective androgen receptor modulator compounds, together with pharmaceutically acceptable excipients.
Owner:UNIV OF TENNESSEE RES FOUND
Synthesis of selective androgen receptor modulators
InactiveUS6995284B2Decreased libidoAlteration in mood and cognitionOrganic active ingredientsCarbamic acid derivatives preparationAging maleProstate cancer incidence
The present invention relates to a synthetic process for the preparation of a novel class of androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. The agents define a new subclass of compounds which are selective androgen receptor modulators (SARM) which are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia, osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and / or prevention of chronic muscular wasting; e) decreasing the incidence of, halting or causing a regression of prostate cancer; f) oral androgen relacement and / or other clinical therpauetic and / or diagnostic areas. The process of the present invention is suitable for large-scale preparation, since all of the steps give rise to highly pure compounds, thus avoiding complicated purification procedures which ultimately lower the yield. Thus the present invention provides methods for the synthesis of non-steroidal agonist compounds, that can be used for industrial large-scale synthesis, and that provide highly pure products in high yield.
Owner:UNIV OF TENNESSEE RES FOUND
Halogenated selective androgen receptor modulators and methods of use thereof
InactiveUS7026500B2Unexpected anabolicUnexpected androgenicBiocideUrea derivatives preparationDiseaseAging male
This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. Other SARM compounds have been found to have an unexpected antiandrogenic activity of a nonsteroidal ligand for the androgen receptor. The SARM compounds, either alone or as a composition, are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia, osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and / or prevention of acute and / or chronic muscular wasting conditions; e) preventing and / or treating dry eye conditions; f) oral androgen replacement therapy; and / or g) decreasing the incidence of, halting or causing a regression of prostate cancer.
Owner:UNIV OF TENNESSEE RES FOUND
Selective androgen receptor modulators and methods of use thereof
InactiveUS6998500B2Reduce incidenceDecreasing regressionBiocideTin organic compoundsDiseaseAging male
This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. Other SARM compounds have been found to have an unexpected antiandrogenic activity of a nonsteroidal ligand for the androgen receptor. The SARM compounds, either alone or as a composition, are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia, osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and / or prevention of acute and / or chronic muscular wasting conditions; e) preventing and / or treating dry eye conditions; f) oral androgen replacement therapy; and / or g) decreasing the incidence of, halting or causing a regression of prostate cancer.
Owner:UNIV OF TENNESSEE RES FOUND
Multi-substitued selective androgen receptor modulators and methods of use thereof
InactiveUS20050033074A1Decreased libidoAlteration in mood and cognitionUrea derivatives preparationSenses disorderDiseaseAging male
This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. Other SARM compounds have been found to have an unexpected antiandrogenic activity of a nonsteroidal ligand for the androgen receptor. The SARM compounds, either alone or as a composition, are usefull for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia, osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and / or prevention of acute and / or chronic muscular wasting conditions; e) preventing and / or treating dry eye conditions; f) oral androgen replacement therapy; and / or g) decreasing the incidence of, halting or causing a regression of prostate cancer.
Owner:UNIV OF TENNESSEE RES FOUND
Selective androgen receptor modulators
Owner:UNIV OF TENNESSEE RES FOUND
Selective androgen receptor modulators
The present invention relates to androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity, which are nonsteroidal ligands for the androgen receptor. The selective androgen receptor modulators (SARM) are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia, osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and / or prevention of chronic muscular wasting; e) decreasing the incidence of, halting or causing a regression of prostate cancer; f) oral androgen replacement and / or other clinical therapeutic and / or diagnostic areas.
Owner:UNIV OF TENNESSEE RES FOUND
Selective androgen receptor modulators
InactiveUS20060276540A1Reduce incidenceDecreasing regressionBiocideOrganic chemistryDiseaseAging male
The present invention relates to androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity, which are nonsteroidal ligands for the androgen receptor. The selective androgen receptor modulators (SARM) are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia,osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and / or prevention of chronic muscular wasting; e) decreasing the incidence of, halting or causing a regression of prostate cancer; f) oral androgen relacement and / or other clinical therpauetic and / or diagnostic areas.
Owner:UNIV OF TENNESSEE RES FOUND
Selective androgen receptor modulators
The present invention relates to androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity, which are nonsteroidal ligands for the androgen receptor. The selective androgen receptor modulators (SARM) are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia, osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and / or prevention of chronic muscular wasting; e) decreasing the incidence of, halting or causing a regression of prostate cancer; f) oral androgen relacement and / or other clinical therpauetic and / or diagnostic areas.
Owner:UNIV OF TENNESSEE RES FOUND
Synthesis of selective androgen receptor modulators
InactiveUS7759520B2Low yieldHighly pure productsBiocideOrganic active ingredientsAging maleProstate cancer incidence
Owner:UNIV OF TENNESSEE RES FOUND
Selective androgen receptor modulators
Owner:UNIV OF TENNESSEE RES FOUND
Multi-substitued selective androgen receptor modulators and methods of use thereof
InactiveUS7803970B2Reduce incidenceDecreasing regressionBiocideUrea derivatives preparationAging maleHyperplasia
Owner:UNIV OF TENNESSEE RES FOUND
Treating androgen decline in aging male (ADAM)-associated conditions with sarms
This invention provides methods for treatment and inhibition of a male subject having an Androgen Decline in Aging Male (ADAM)-associated condition, for example sexual dysfunction, decreased sexual libido, erectile dysfunction, hypogonadism, sarcopenia, osteopenia, osteoporosis, an alteration in cognition and mood, depression, anemia, hair loss, obesity, muscle loss, dry eye, memory loss, benign prostate hyperplasia and / or prostate cancer, by administering to the subject a selective androgen receptor modulator (SARM) compound and / or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, pro-drug, polymorph, crystal, or any combination thereof.
Owner:UNIV OF TENNESSEE RES FOUND
Prodrugs of selective androgen receptor modulators and methods of use thereof
InactiveUS7595402B2Suppressing spermatogenesisInhibit productionBiocideSenses disorderDysostosisSelective androgen receptor modulator
Owner:ONCTERNAL THERAPEUTICS INC
Medicine for treating impotence and premature ejaculation and preparation method thereof
InactiveCN102579770AGood treatment effectIncrease libidoHeavy metal active ingredientsSexual disorderSide effectAging male
The invention aims to provide a medicine which is prepared from animal and plant Chinese herbal medicines serving as raw materials and is used for treating impotence and premature ejaculation and a preparation method thereof. By the method, the problems of poor effect, slow response, high possibility of relapse and the like in the prior art are solved. The medicine has the characteristics of quick response and lasting effect, and is prepared from the following raw materials in part by weight: 20 to 50 parts of songaria cynomorium herb, 20 to 50 parts of desertliving cistanche, 40 to 60 parts of common curculigo rhizome, 10 to 30 parts of tremolite or tremolite asbestos, 30 to 50 parts of medicinal indianmulberry root, 20 to 40 parts of hairy antler, 30 to 50 parts of pangolin scales, 30 to 50 parts of pipe fish, 50 to 80 parts of astragalus, 30 to 50 parts of south dodder seed and 20 to 40 parts of tuber onion seed. The method comprises the following steps of: drying the raw materials, crushing into 100 to 200-mesh fine powder, and sieving; and mixing uniformly in the ratio, and sterilizing to prepare the medicine. The medicine is prepared from the natural animal and plant Chinese herbal medicines, is mild in medicinal property, does not have toxic or side effect and cause adverse reaction, and is suitable to be taken by right-age males who suffer from impotence and premature ejaculation for a long time.
Owner:姜春凤 +1
Preparation for tonifying Yang, strengthening body and improving immunity and preparation method of preparation
InactiveCN105055492ASolve the problem of difficult powder compressionSolving Difficult Tablet ProblemsOrganic active ingredientsPharmaceutical delivery mechanismMale infertilityAging male
The invention discloses a preparation for tonifying Yang, strengthening body and improving immunity and a preparation method of the preparation, belongs to the technical field of health food. The preparation for tonifying Yang, strengthening body and improving immunity comprises tablet cores, wherein the tablet cores comprise the following components in percentage by mass: 75-85% of L-arginine monohydrochloride Maca particles, 8-15% of sorbitol, 3-7% of microcrystalline cellulose, 0.5-1.5% of croscarmellose sodium and 0.5-1.5% of magnesium stearate; the invention further discloses the preparation method of the preparation. The preparation provided by the invention is suitable for young, middle-aged and elderly men, and has obvious improving effects on the male infertility, sexual dysfunction, sexual capacity decline and prostatic gland problems and people with kidney deficiency and body weakness.
Owner:JIANGSU ALAND NOURISHMENT
Improvement in muscle functionality of elderly males
PendingCN106793806ASarcopenia reductionReduce lossesFood ingredient as antioxidantPeptide/protein ingredientsMuscle strengthAntioxidant
A composition comprising a protein source and an antioxidant, optionally in combination with an omega-3 fatty acid, can treat or prevent sarcopenia in elderly males, reduce a loss of muscle functionality (e.g. muscle strength, gait speed, etc.) in elderly males, increase muscle functionality in elderly males, and / or improve recovery of muscle functionality after muscle atrophy in elderly males.
Owner:SOC DES PROD NESTLE SA
Treating androgen decline in aging male (ADAM)-associated conditions with SARMS
InactiveUS20050080054A1Safe and effectiveReduce morbidityBiocideNervous disorderMetaboliteAging male
The present invention provides a method of treating, preventing, suppressing, inhibiting or reducing the incidence of an Androgen Decline in Aging Male (ADAM)-associated condition in a male subject, by administering to the subject a selective androgen receptor modulator (SARM) compound and / or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, prodrug, polymorph, crystal, or any combination thereof. The present invention further provides a method of treating, preventing, suppressing, inhibiting or reducing the incidence of sexual dysfunction, decreased sexual libido, erectile dysfunction, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, benign prostate hyperplasia or prostate cancer due to ADAM in a male subject, by administering to the subject a selective androgen receptor modulator (SARM) compound and / or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, prodrug, polymorph, crystal, or any combination thereof.
Owner:GTX INCORPORATED +1
N-bridged selective androgen receptor modulators and methods of use thereof
InactiveCN101333174AReduce morbidityPrevent fadingSenses disorderNervous disorderAging maleProstate cancer incidence
Owner:UNIV OF TENNESSEE RES FOUND
Treating androgen decline in aging male (ADAM)-associated conditions with SARMs
This invention provides methods for treatment and inhibition of a male subject having an Androgen Decline in Aging Male (ADAM)-associated condition, for example sexual dysfunction, decreased sexual libido, erectile dysfunction, hypogonadism, sarcopenia, osteopenia, osteoporosis, an alteration in cognition and mood, depression, anemia, hair loss, obesity, muscle loss, dry eye, memory loss, benign prostate hyperplasia and / or prostate cancer, by administering to the subject a selective androgen receptor modulator (SARM) compound and / or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, pro-drug, polymorph, crystal, or any combination thereof.
Owner:UNIV OF TENNESSEE RES FOUND
Sea cucumber seminal vesicle extract for treating partial androgen deficiency of aging males (PADAM)
InactiveCN103316048AImprove the effect of PADAMIncrease contentSexual disorderEchinodermata material medical ingredientsRotary evaporatorAlcohol
The invention discloses a sea cucumber seminal vesicle extract for treating partial androgen deficiency of aging males (PADAM) and a preparation method thereof and relates to the technical field of processes for extracting active substances from sea cucumber seminal vesicles. The preparation method of the sea cucumber seminal vesicle extract comprises the steps of carrying out freeze drying on right amount of the pre-frozen sea cucumber seminal vesicle, smashing, adding absolute ethyl alcohol in the mass ratio of 1:10, carrying out stirring extraction at 30 DEG C for 3 hours, taking out the filtrate after filtering, repeatedly carrying out the operations on the residue, mixing the filtrates, recovering the ethyl alcohol by using a rotary evaporator, and carrying out vacuum drying on the concentrated solution to obtain the sea cucumber seminal vesicle extract. The sea cucumber seminal vesicle extract can be prepared into tablets and capsules and is used for treating the PADAM.
Owner:QINGDAO UNIV
Dasyatis sinensis extract for treating partial androgen deficiency in aging males
InactiveCN107737141AImprove the effect of PADAMIncrease contentFish material medical ingredientsSexual disorderDasyatisSide effect
The invention relates to a dasyatis sinensis extract for treating partial androgen deficiency in aging males (PADAM). The dasyatis sinensis extract is extracted from cartilage of dasyatis sinensis, can increase testis and epididymis indexes of cyclophosphamide-induced PADAM model mice, increase sperm density, increase a rate of motion and reduce an aberration rate, can be prepared into multiple preparations, can be used for treating the PADAM, and has the characteristics of remarkable curative effect, no side effects, low price, safety and convenience.
Owner:QINGDAO UNIV
Non-steroidal male hormone receptor regulating agent and medical uses thereof
InactiveCN101284795AReduce morbidityPrevent fadingOrganic active ingredientsNervous disorderHormone Receptor ModulatorsAging male
The invention relates to a non-steroidal male sex hormone receptor modulator or the receivable slat thereof in pharmacy, in particular to a compound for preparing non-steroidal drugs used for preventing and / or curing the partial androgen deficiency in aging males, osteoporosis, myophagism, female sexual insufficiency, anorexia, female polytrichia, severe androgen-dependent type alopecia, acne, cachexia, benign prostatic hyperplasia, prostatic cancer, breast cancer, alzheimer disease, parkinsonism syndrome, etc. The invention also relates to a drug combination containing a general formula I compound or an acceptable salt thereof in pharmacy, and the use of the drug combination containing the general formula I compound or the acceptable salt in pharmacy for preparing drugs to cure the above symptoms or diseases.
Owner:SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI +1
Calculation method for prompting Alzheimer's disease risk of old men by androgen
InactiveCN111415745AHigh predictive valueHelpful reference limitHealth-index calculationMedical automated diagnosisAging maleBoundary values
The invention provides a calculation method for prompting the Alzheimer's disease (AD) risk of old men by androgen. The method comprises the following steps: constructing an equation model, fitting anROC curve, and calculating a diagnosis boundary value cutoff value, so as to obtain an androgen laboratory reference value of amnetic mild cognitive impairment (aMCI). The method comprises the following specific steps: referring to a result of single-factor analysis of aMCI and cognitive normality comparison, selecting variables with statistical significance to further perform multi-factor logistic regression analysis to obtain independent prediction factors of aMCI, and constructing an equation; the method has a high prediction value, and can prompt possible aMCI risks.
Owner:HEBEI MEDICAL UNIVERSITY
Pharmaceutical activity and manufacturing method of the compound recipe product of 4 kinds of plants to increase testosterone
InactiveUS20050142221A1Increase volumeImprove cell activityBiocideUnknown materialsPhysiologyAging male
The partial androgen deficiency of the aging male (PADAM) and the supplement of synthetic testosterone is an important research subject in the American biological science. The activity of leydigs cells of testis and the synthesizing and excreting state of testosterone has aroused wide concern of the medical circles. Taking synthetic testosterone may cause the cancer of genital system, which makes the middle-aged and old male people do not dare to taking the drugs of the synthetic testosterone. The Compound Recipe Product of 4 Kinds of Plants to Increase Testosterone is made by following procedures: Under the carefully and strictly controlled condition, use the technology of absorption and elution of WLD resin to extract and purify it and measured by the gas chromatograph and make a fingerprinting chromatograph quantitative determination so as to guarantee the product has a stable technological process and a high quality. The experiment of pharmacological activity shows that, by activating the leydigs cells of testis to enhance its ability to excrete testosterone, the compound recipe product has a remarkable function to obviously raise the quantity of testosterone blood serum of the normal and injured genital system and is used for treating the partial androgen deficiency of the aging male (PADAM) in clinical treatment.
Owner:GONG JIAO +1
Method for improving egg laying performance of natural-mating cage-raising breeding hens
The invention relates to a method for improving the egg laying performance of natural-mating cage-raising breeding hens. The method comprises the steps that one-day-age male chicks are taken, the tiptoes of the second toe and the fourth toe of each male chick are broken, and the male chicks and female chicks are put into a natural-mating cage in proportion to be raised, wherein toe breaking operation is conducted through an electric heating poultry debeaker and needs to be thorough, and the bones and the skin of the toes of the male chicks are prevented from being damaged. The method is simple, easy to operate and high in applicability; the defects of a natural-mating cage-raising mode are effectively avoided, so that the egg laying rate of the breeding hens is increased by 5% or above; the method can be applied to large-scale raising of parent-generation breeding hens with the high egg laying yield.
Owner:INST OF ANIMAL HUSBANDRY & VETERINARY MEDICINE ANHUI ACAD OF AGRI SCI
Medicinal composition for treating old-age male hyperlipidemia and preparation method and application thereof
InactiveCN102824415AGood effectMetabolism disorderPlant ingredientsRed yeast ricePhyllanthus urinaria
The invention discloses a medicinal composition for treating the old-age male hyperlipidemia and a preparation method and application thereof. The medicinal composition for treating the old-age male hyperlipidemia is prepared by using phyllanthus urinaria, polygala arillata, epimedium herb and red yeast rice as raw materials; and the mass percentage of any component does not exceed 30 percent of the total mass percentage of the components. According to the physiological characteristic that a patient suffering from the old-age male hyperlipidemia also has the symptom of androgen reduction, the invention provides the medicinal composition with strong pertinence; and the screening range is enlarged to natural medicaments of folk medicine. Animal experiments and a clinical test result show that the medicinal composition has the characteristic of obvious effects and is a novel medicament for treating the old-age male hyperlipidemia.
Owner:GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
Metabolites of selective androgen receptor modulators and methods of use thereof
InactiveCN1972682AInduce apoptosisDecreased libidoTin organic compoundsSugar derivativesMetaboliteAging male
This invention provides metabolites of a class of androgen receptor targeting agents (ARTA). The SARM compounds and their metabolites, either alone or as a composition, are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia, osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition, and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and / or prevention of acute and / or chronic muscular wasting conditions; e) preventing and / or treating dry eye conditions; f) oral androgen replacement therapy; g) decreasing the incidence of, halting or causing a regression of prostate cancer; and / or h) inducing apoptosis in a cancer cell.
Owner:UNIV OF TENNESSEE RES FOUND
Medicinal composition for treating old-age male hyperlipidemia and preparation method and application thereof
InactiveCN102824415BGood effectMetabolism disorderPlant ingredientsRed yeast ricePhyllanthus urinaria
Owner:GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
Large-scale synthesis of selective androgen receptor modulators
The present invention relates to a synthetic process for the preparation of a novel class of androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. The agents define a new subclass of compounds which are selective androgen receptor modulators (SARM) which are useful for a) male contraception; b) treatment ofa variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia, osteoporosis, and alterations in mood and cognition; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity and endometriosis, d) treatment and / or prevention of chronic muscular wasting; e) decreasing the incidence of, halting or causing a regression of prostate cancer; f) oral androgen replacement; g) preventing and / or treating dry eye conditions; h) treatment and / or prevention of begnin prostate hyperplasia (BPH); I) inducing apoptosis in a cancer cell; j) treatment and / or prevention of cancers of female sexual organs such as breast cancer, uterine cancer and ovarian cancer; and / or other clinical therapeutic and / or diagnostic areas. The process of the present invention is suitable for large-scale preparation, since all of the steps give rise to highly pure compounds, thus avoiding complicated purification procedures which ultimately lower the yield. Thus the present invention provides methods for the synthesis of non-steroidal agonist compounds, that can be used for industrial large-scale synthesis, and that provide highly pure products in high yield.
Owner:UNIV OF TENNESSEE RES FOUND
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