Medicinal composition for treating old-age male hyperlipidemia and preparation method and application thereof

A technology of hyperlipidemia and composition, which is applied in the field of pharmaceutical composition for the treatment of hyperlipidemia in elderly men, can solve the problem of rarely reporting random large-scale clinical research results, lack of data on the efficacy and safety of statins in the elderly, etc. problem, to achieve remarkable results

Inactive Publication Date: 2012-12-19
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(Hu Dayi. The era of intensive lipid-lowering for high-risk groups has come—From 4S to ID EAL. Clinical Collection [J]. 2006, 21: 305-307) However, the vast majority of elderly patients in my country have mild or moderate dyslipidemia. Different from western countries, there is a lack of data on the efficacy and safety of statins in the elderly, and there are few reports of randomized large-scale clinical studies of statins in the elderly ≥ 80 years old

Method used

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  • Medicinal composition for treating old-age male hyperlipidemia and preparation method and application thereof
  • Medicinal composition for treating old-age male hyperlipidemia and preparation method and application thereof
  • Medicinal composition for treating old-age male hyperlipidemia and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0040] At room temperature, take 10 kg each of Phyllostachys phylloxera, Huanghua Shuidaolian, Epimedium, and Monascus (40 kg in total), soak and extract with 400 kg of ethanol with a volume concentration of 95%, and soak for 24 hours. Press and recover the ethanol to obtain the extract, and dry the extract in an oven at 100°C for 5 hours to obtain the ethanol extract;

[0041] Use ethanol to extract the Phyllostachys phylloxera, Shuidaolian, Epimedium, and Monascus with 400 kg of water to reflux for 2 hours. When the extract is concentrated to 25°C, the specific gravity is 1.05-1.10, dried, and extracted with water. thing;

[0042] The medicinal composition for treating hyperlipidemia in aged males is obtained by mixing ethanol extracts and water extracts of Phyllostachys phylloxera, Shuidaolian, Epimedium and Monascus.

[0043] 100 grams of the obtained pharmaceutical composition for treating hyperlipidemia in elderly men can be mixed with 100 grams of soluble starch, and p...

Embodiment 2

[0045] At room temperature, take 12 kilograms of Phyllostachys phylloxera, 6 kilograms of Huanghua Shuidaolian, 8 kilograms of Epimedium, and 14 kilograms of red yeast rice (total 40 kilograms), soak and extract with 400 kilograms of methanol with a volume concentration of 70%, and the soaking time is After 24 hours, the methanol was recovered under reduced pressure to obtain the extract, and the extract was dried in an oven at 100°C for 5 hours to obtain the methanol extract;

[0046] Use 400 kg of reflux to extract the Methanol-extracted Phyllostachys phylloxera, Shuidaolian, Epimedium, and Monascus for 4 hours. When the extract is concentrated to 25°C, the specific gravity is 1.05-1.10, and dried to obtain the water extract. ;

[0047] The pharmaceutical composition for treating hyperlipidemia in aged males is obtained by mixing methanol extracts and water extracts of Phyllostachys phylloxera, Shuidaolian, Epimedium and Monascus.

[0048] Mix 100 grams of the obtained phar...

Embodiment 3

[0050] At room temperature, take 6 kilograms of Phyllostachys phylloxera, 6 kilograms of Huanghua Shuidaolian, 10 kilograms of Epimedium, and 18 kilograms of Monascus (40 kilograms in total), soak and extract with 400 kilograms of ethyl acetate for 24 hours. Compress the recovered ethyl acetate to obtain the extract, and dry the extract in an oven at 100°C for 5 hours to obtain the ethyl acetate extract;

[0051] Extract the Phyllostachys phylloxera, Shuidaolian, Epimedium, and Monascus extracted by ethyl acetate with 400 kg of water for 2 hours. When the extract is concentrated to 25°C, the specific gravity is 1.05-1.10, and it is dried to obtain water extract;

[0052] The medicinal composition for treating hyperlipidemia in aged males is obtained by mixing the ethyl acetate extracts and water extracts of Phyllostachys phylloxera, Shuidaolian, Epimedium, and Monascus.

[0053] Mix 100 grams of the obtained pharmaceutical composition for treating hyperlipidemia in elderly me...

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Abstract

The invention discloses a medicinal composition for treating the old-age male hyperlipidemia and a preparation method and application thereof. The medicinal composition for treating the old-age male hyperlipidemia is prepared by using phyllanthus urinaria, polygala arillata, epimedium herb and red yeast rice as raw materials; and the mass percentage of any component does not exceed 30 percent of the total mass percentage of the components. According to the physiological characteristic that a patient suffering from the old-age male hyperlipidemia also has the symptom of androgen reduction, the invention provides the medicinal composition with strong pertinence; and the screening range is enlarged to natural medicaments of folk medicine. Animal experiments and a clinical test result show that the medicinal composition has the characteristic of obvious effects and is a novel medicament for treating the old-age male hyperlipidemia.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating hyperlipidemia in elderly males. Background technique [0002] Blood lipid is a necessary factor for the formation of atherosclerotic lesions, and abnormal blood lipid is an important risk factor for cardiovascular diseases, especially coronary heart disease. A large-scale population survey in my country in 2005 showed that the situation of dyslipidemia in the Chinese population is severe. The total prevalence of dyslipidemia among adults aged 18 and over in my country was 18.6%. Dyslipidemia has become an important risk factor threatening the health of our people. (Zhao Wenhua, Zhang Jian, You Yue et al. Research on the prevalence of dyslipidemia in Chinese population aged 18 and over [J]. Chinese Journal of Preventive Medicine, 2005, 39 (5): 306-310) Although statins, fibrates and other drugs The lipid-lowering effect is obvious, but there are also serious side effects such as rhabdo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/69A61P3/06
Inventor 朱伟黄羽贺嵩敏黄海定卢传礼
Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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