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Dasyatis sinensis extract for treating partial androgen deficiency in aging males

An extract, a technology for middle-aged and elderly people, applied in the application field of Chinese stingray extract in the treatment of partial androgen deficiency syndrome in middle-aged and elderly men

Inactive Publication Date: 2018-02-27
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The effect of Chinese ray extract on the treatment of PADAM has not been reported

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0011] 1. Preparation of tablets and capsules:

[0012] (1) Preparation of Chinese stingray extract capsule preparation of the present invention

[0013] Weigh 200 mg of Chinese stingray extract, meanwhile weigh 295 mg of starch and 5 mg of magnesium stearate, mix them evenly, and fill them into capsules.

[0014] (2) Preparation of Chinese stingray extract tablets of the present invention

[0015] Weigh 200 mg of Chinese stingray extract, at the same time weigh 195 mg of starch and 100 mg of lactose, mix them evenly, use wet granulation, and compress into tablets.

[0016] 2. The effect of Chinese stingray extract on the reproductive system of male mice

[0017] (1) Test object:

[0018] Male Kunming mice, 8-10 weeks (25-30g), purchased from Shandong Lukang Pharmaceutical Co., Ltd., clean grade, reared at room temperature, free drinking and eating

[0019] (2) Reagent

[0020] Testosterone radioimmunoassay kit, purchased from Beijing Northern Institute of Biotechnology

[0021] Cyclophospha...

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Abstract

The invention relates to a dasyatis sinensis extract for treating partial androgen deficiency in aging males (PADAM). The dasyatis sinensis extract is extracted from cartilage of dasyatis sinensis, can increase testis and epididymis indexes of cyclophosphamide-induced PADAM model mice, increase sperm density, increase a rate of motion and reduce an aberration rate, can be prepared into multiple preparations, can be used for treating the PADAM, and has the characteristics of remarkable curative effect, no side effects, low price, safety and convenience.

Description

Technical field [0001] The invention relates to the technical field of health-care medicines and foods, and specifically to the application of Chinese rays extracts in the treatment of partial androgen deficiency syndromes in middle-aged and elderly men. Background technique [0002] Partial Androgen Deficiency Syndrome (PADAM) in middle-aged and elderly men is a group of clinical syndromes that appear due to the gradual aging of the mechanism, endocrine function, especially hypogonadism, and disorder of male hormone regulation when men transition from middle-aged to old age; also Said male menopausal syndrome, menopausal depression, and male presenile syndromes. [0003] Currently, PADAM patients are internationally advocated for testosterone supplementation, such as fatty acid esters of testosterone (Anter), methyltestosterone, testosterone propionate, etc., while testosterone supplementation can only relieve some of the symptoms, and the resulting safety Sexual problems have gr...

Claims

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Application Information

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IPC IPC(8): A61K35/60A61P5/26A61P15/12A61P15/00
CPCA61K35/60
Inventor 高华刘坤石振艳
Owner QINGDAO UNIV
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