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Chimaera phantasma extract for treating partial androgen deficiency in aging male (PADAM)

An extract, middle-aged and elderly technology, applied in the direction of medical raw materials derived from fish food, diseases, drug combinations, etc., can solve problems such as unreported effects

Inactive Publication Date: 2018-03-06
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Distributed in the western Pacific Ocean, China is produced in the South China Sea, the East China Sea and the Yellow Sea, and its internal skeleton is all cartilage. The inventors extracted the black-lined chimaera extract from the black-lined chimaera cartilage, and confirmed that the extract is effective for alcohol-induced liver damage. Has a protective effect (see 201510607245.5), but its effect on the treatment of PADAM has not been reported

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0011] 1. Preparation of tablets and capsules:

[0012] (1) Preparation of the black line chimaera extract capsule preparation of the present invention

[0013] Weigh 200 mg of black line chimaera extract, simultaneously weigh 295 mg of starch and 5 mg of magnesium stearate, mix them evenly, and fill them into capsules.

[0014] (2) Preparation of the black line chimaera extract tablet of the present invention

[0015] Weigh 200 mg of chimaera extract, 195 mg of starch and 100 mg of lactose at the same time, mix evenly, granulate by wet method, and press into tablets.

[0016] 2. Effects of chimaera extract on the reproductive system of male mice

[0017] (1) Test object:

[0018] Male Kunming mice, 8-10 weeks old (25-30g), purchased from Shandong Lukang Pharmaceutical Co., Ltd., clean grade, kept at room temperature, free to drink water and eat

[0019] (2) Reagents

[0020] Testosterone radioimmunoassay kit, purchased from Beijing North Institute of Biotechnology

[00...

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Abstract

The invention relates to Chimaera phantasma extract for treating partial androgen deficiency in aging male (PADAM). The Chimaera phantasma extract is obtained by extracting Chimaera phantasma cartilage. The Chimaera phantasma extract can increase testis and epididymis indexes of a PADAM-model mouse caused by cyclophosphamide, and can increase the sperm density, increase the motion rate and decrease the aberration rate; the Chimaera phantasma extract can be prepared into various dosage forms, can be used for treating the partial androgen deficiency in aging male, and has the characteristics ofsignificant curative effect, no side effect, low price, safety and convenience.

Description

technical field [0001] The invention relates to the technical field of health-care medicines and foods, in particular to the application of chimaera extract in the treatment of partial androgen deficiency syndrome in middle-aged and elderly males. Background technique [0002] Partial androgen deficiency syndrome in middle-aged and elderly males (PADAM) is a group of clinical syndromes caused by the gradual aging mechanism, endocrine function, especially hypogonadism, and male hormone regulation disorder when men transition from middle-aged to old age; It is called andropause syndrome, menopausal depression, and male senility. [0003] At present, the international advocates testosterone supplementation therapy for PADAM patients, such as testosterone fatty acid ester (Andrell), methyltestosterone, testosterone propionate, etc., and testosterone supplementation therapy can only relieve part of the symptoms, and the resulting safety Sexual problems have gradually aroused peo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/60A61P15/12
CPCA61K35/60
Inventor 石振艳刘坤高华
Owner QINGDAO UNIV
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