Raja porosa gunther extract used for treating partial androgen deficiency of aging male (PADAM)

An extract, middle-aged and elderly technology, applied in the fields of medical raw materials derived from fish feed, sexual diseases, drug combinations, etc., can solve problems such as unreported effects, and achieve increased serum testosterone content, reduced deformity rate, and increased exercise rate. Effect

Inactive Publication Date: 2018-03-02
QINGDAO UNIV
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AI Technical Summary

Problems solved by technology

All in the Yellow Sea and the Bohai Sea all year round, the output is large, and it is an important fishery catch object. Its endoskeleton is all cartilage, and the fin rays are horny fin rays. The inventor extracts the ray extract from the ray cartilage, and It is confirmed that the extract has a protective effect on alcoholic liver injury (see ZL201310513265.7), but its effect on the treatment of PADAM has not been reported

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0011] 1. Preparation of tablets and capsules:

[0012] (1) Preparation of Kongray Extract Capsule Preparation of the present invention

[0013] Weigh 200 mg of the ray extract, 295 mg of starch and 5 mg of magnesium stearate at the same time, mix them evenly, and fill them into capsules.

[0014] (2) Preparation of the ray extract tablet of the present invention

[0015] Weigh 200mg of Kongray extract, weigh 195mg starch and 100mg lactose at the same time, mix evenly, granulate by wet method, and press into tablets.

[0016] 2. The effect of Kongray extract on the reproductive system of male mice

[0017] (1) Test object:

[0018] Male Kunming mice, 8-10 weeks old (25-30g), purchased from Shandong Lukang Pharmaceutical Co., Ltd., clean grade, kept at room temperature, free to drink water and eat

[0019] (2) Reagents

[0020] Testosterone radioimmunoassay kit, purchased from Beijing North Institute of Biotechnology

[0021] Cyclophosphamide for injection, 0.2g / bottle, p...

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PUM

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Abstract

The invention provides raja porosa gunther extract used for treating partial androgen deficiency of the aging male (PADAM). The raja porosa gunther extract is prepared by extracting the cartilage of raja porosa gunther; the raja porosa gunther extract can increase the testis and epididymis indexes of the PADAM model mouse caused by cyclophosphoramide, improve the density of the sperms, and improvethe movement rate of the sperms, the deformity rate is reduced, and the raja porosa gunther extract can be prepared into various dosage forms, and has the advantages and features that the curative effects are obvious, no side effects exist, the price is low, and the use is safe and convenient when used for treating partial androgen deficiency of the aging male (PADAM).

Description

technical field [0001] The invention relates to the technical field of health-care medicine and food, in particular to the application of Kongray extract in the treatment of partial androgen deficiency syndrome in middle-aged and elderly men. Background technique [0002] Partial androgen deficiency syndrome in middle-aged and elderly males (PADAM) is a group of clinical syndromes caused by the gradual aging mechanism, endocrine function, especially hypogonadism, and male hormone regulation disorder when men transition from middle-aged to old age; It is called andropause syndrome, menopausal depression, and male senility. [0003] At present, the international advocates testosterone supplementation therapy for PADAM patients, such as testosterone fatty acid ester (Andrell), methyltestosterone, testosterone propionate, etc., and testosterone supplementation therapy can only relieve part of the symptoms, and the resulting safety Sexual problems have gradually aroused people's...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/60A61P5/26A61P15/12A61P15/00
CPCA61K35/60
Inventor 刘坤高华石振艳
Owner QINGDAO UNIV
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