Calculation method for prompting Alzheimer's disease risk of old men by androgen

A technology of Alzheimer's disease and calculation method, which is applied in the field of calculation of androgen prompting the risk of Alzheimer's disease in elderly men. It can solve the problems of complex operation, large invasiveness, and difficulty in large-scale application, and achieve high prediction value effect
CN111415745AInactive Publication Date: 2020-07-14HEBEI MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
HEBEI MEDICAL UNIVERSITY
Publication Date
2020-07-14
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a calculation method for prompting the Alzheimer's disease (AD) risk of old men by androgen. The method comprises the following steps: constructing an equation model, fitting anROC curve, and calculating a diagnosis boundary value cutoff value, so as to obtain an androgen laboratory reference value of amnetic mild cognitive impairment (aMCI). The method comprises the following specific steps: referring to a result of single-factor analysis of aMCI and cognitive normality comparison, selecting variables with statistical significance to further perform multi-factor logistic regression analysis to obtain independent prediction factors of aMCI, and constructing an equation; the method has a high prediction value, and can prompt possible aMCI risks.
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Description

technical field

[0001] The invention relates to a risk calculation method, in particular to a calculation method for androgen prompting the risk of Alzheimer's disease in elderly men. Background technique

[0002] The world's first internationally recognized diagnostic criteria for Alzheimer's Disease (AD) was the NINCDS-ADRDA diagnostic criteria published by the National Association of Neurology and Speech Disorders, Stroke and Alzheimer's Disease and Related Diseases in 1984. Over the past 30 years, as people's understanding of AD disease and the ability to detect its pathophysiological process have improved, the concept of the clinical spectrum of the disease has undergone earth-shaking changes. AD diagnostic criteria are also constantly updated and improved, after NINCDS-ADRDA criteria (1984) - IWG criteria (2007, 2010) - NIA-AA criteria (2011) - IWG2 criteria (2014) 4 stage. Whether it is the NIA-AA criteria or the IWG criteria, there is consensus on the concept of AD...

Claims

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