The present invention relates to a use of a composition comprising a
zinc salt; and cyclohistidine-
proline as an effective ingredient for preventing, ameliorating or treating
diabetic nephropathy, and more particularly, to provide a composition comprising a
zinc salt; and cyclohistidine-
proline as an effective ingredient and a method for preventing, ameliorating or treating
diabetic nephropathy using the same, wherein the composition exhibits a preventive, ameliorative or
therapeutic effect on
diabetic nephropathy through an effect of reducing
albuminuria, reducing an
albumin /
creatinine ratio or increasing glomerular
filtration rate when the composition is administered alone or in combination with an antihypertensive agent and / or an antidiabetic agent.