Formulation and method for the prevention and/or treatment of hangover symptoms

Abstract

A formulation and a method for treating, preventing, ameliorating or alleviating in a patient the symptoms of hangover, or of veisalgia, associated with a bout of excessive alcohol consumption are disclosed. More specifically, a formulation comprising L-cysteine, thiamine and pyridoxine and a method for treating, preventing, ameliorating or alleviating in a patient one or more of the symptoms of nausea, headache, diminished concentration, malaise and/or tiredness, and a desire to consume greasy and/or fatty and/or oily foods, associated with a bout of excessive alcohol consumption are disclosed.

Description

FIELD OF THE INVENTION[0001]The invention relates to formulations and methods for the prevention and / or treatment of hangover symptoms associated with alcohol consumption.BACKGROUND TO THE INVENTION[0002]Alcohol induced hangover, also known as veisalgia, is a syndrome comprised of a range of symptoms including nausea, headache, diminished concentration, malaise and / or tiredness, and a desire to consume greasy and / or fatty and / or oily foods (amongst others) that typically occurs the day following overindulgence in alcohol. Although the precise pathogenesis of hangover is not known and likely to be due to multiple factors, there is considerable evidence that the accumulation of acetaldehyde plays a significant role [14, 15, 16, 17]. Alcohol is rapidly metabolized to acetaldehyde by the enzyme alcohol dehydrogenase. Acetaldehyde is then metabolized by aldehyde reductase to acetate.[0003]The following formulas illustrate these reactions:CH3CH2OH+NAD+→CH3CHO+NADH+H+  1)Acetaldehyde+NAD++...

AI Technical Summary

Benefits of technology

[0055]For example, the tear difficulty can alternate such that it is, for example, relatively easier to separate two sachets at a time from a length of sachets (than it would be to separate each sachet from a pair). Such embodiments facilitate dispensing of the product in pairs of sachets. Some of these embodiments are provided in the form of a reel, wherein the desirable number of sachets to be acquired can be dispensed by tearing the tearable join when the reel has been unwound sufficiently to expose the desired number of sachets.

[0056]The join between sachet

Problems solved by technology

However, when too much alcohol is consumed the body is overwhelmed and cannot effectively metabolize all the acetaldehyde that is being produced.

Alcohol induced hangover is responsible for a significant degree of morbidity in the community and it is responsible for a high level of loss of productivity due to absenteeism from work and poor work performance [10, 12, 15].

Due to side effects such as headache, nausea and a general feeling of malaise many hours of work and relaxation time are lost because of the inability to be productive.

However, PubMed database searches of the ingredients variously contained in those products reveal that none of them have been studied, other than Red Ginseng and glucose [6, 19].

Specifically, disulfiram is prescribe

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